Semi-mechanistic population pharmacokinetic modeling of DZIF-10c, a neutralizing antibody against SARS-Cov-2: predicting systemic and lung exposure following inhaled and intravenous administration.

Autor: Kurup S; Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT, 06877, USA. sree.kurup@boehringer-ingelheim.com., de Mendizabal NV; Metrum Research Group, Tariffville, CT, 06081, USA.; Gilead, Foster City, CA, 94404, USA., Becker S; Institute of Virology, Philipps University Marburg, 35043, Marburg, Germany.; German Center for Infection Research (DZIF), Partner Site Giessen-Marburg-Langen, 35043, Marburg, Germany., Bolella E; Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 06877, USA., De Sousa D; Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT, 06877, USA., Fätkenheuer G; Department of Internal Medicine 1, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50931, Cologne, Germany., Gruell H; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Klein F; German Center for Infection Research (DZIF), Partner Site Giessen-Marburg-Langen, 35043, Marburg, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50931, Cologne, Germany.; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Malin JJ; Department of Internal Medicine 1, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50931, Cologne, Germany., Schmid U; Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach an der Riss, Germany., Korell J; Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT, 06877, USA.; Metrum Research Group, Tariffville, CT, 06081, USA.

Publikováno v: Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2024 Dec 05; Vol. 52 (1), pp. 3. Date of Electronic Publication: 2024 Dec 05.

Bounded integer model-based analysis of psoriasis area and severity index in patients with moderate-to-severe plaque psoriasis receiving BI 730357.

Autor: Ooi QX; Pharmetheus AB, Uppsala, Sweden., Kristoffersson A; Pharmetheus AB, Uppsala, Sweden., Korell J; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA., Flack M; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA., L Plan E; Pharmetheus AB, Uppsala, Sweden., Weber B; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Jun; Vol. 12 (6), pp. 758-769. Date of Electronic Publication: 2023 May 01.

Optimizing Antipsychotic Patient Management Using Population Pharmacokinetic Models and Point‐of‐Care Testing

Autor: Green, B, Korell, J, Remmerie, B, Savitz, A, Vermeulen, A

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology

Schizophrenia is a common disease, characterized by progressive functional decline exacerbated by psychotic relapses that often result from a lack of full adherence to antipsychotic (APS) medication. Although atypical APS medications do not have clea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::249a6e45ea61f154a43d8aa87b5dbe8d
http://europepmc.org/articles/PMC5613188

Population Pharmacokinetic Model of Vitamin D 3 and Metabolites in Chronic Kidney Disease Patients with Vitamin D Insufficiency and Deficiency.

Autor: Tuey, Stacey M.¹ (AUTHOR) avisek.ghimire@cuanschutz.edu, Ghimire, Avisek¹ (AUTHOR) amandla.atilanoroque@uchealth.org, Guzy, Serge² (AUTHOR) poppharm2@gmail.com, Prebehalla, Linda³ (AUTHOR) lprebeh@pitt.edu, Roque, Amandla-Atilano¹ (AUTHOR) gavriel.roda@cuanschutz.edu, Roda, Gavriel¹ (AUTHOR), West 3rd, Raymond E.³ (AUTHOR) nolin@pitt.edu, Chonchol, Michel B.⁴ (AUTHOR) michel.chonchol@cuanschutz.edu, Shah, Nirav⁵ (AUTHOR) nas65@pitt.edu, Nolin, Thomas D.³ (AUTHOR), Joy, Melanie S.^1,4 (AUTHOR) melanie.joy@cuanschutz.edu

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12279. 17p.

Pharmacokinetic-pharmacodynamic modelling and simulation of methotrexate dosing in patients with rheumatoid arthritis.

Autor: Tan JM; University of South Australia (UniSA: Clinical and Health Sciences, Centre for Pharmaceutical Innovation), Adelaide, South Australia, Australia., Upton RN; Australian Centre for Pharmacometrics, University of South Australia, Adelaide, South Australia, Australia., Foster DJR; Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, South Australia, Australia., Proudman SM; Royal Adelaide Hospital, Adelaide (South Australia), Australia. Discipline of Medicine, University of Adelaide, Adelaide, Australia., Dhir V; Clinical Immunology and Rheumatology Unit, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Wiese MD; University of South Australia (UniSA: Clinical and Health Sciences, Centre for Pharmaceutical Innovation), Adelaide, South Australia, Australia.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Nov; Vol. 90 (11), pp. 2763-2780. Date of Electronic Publication: 2024 Jul 05.