CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals.

Autor: Gristick HB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Hartweger H; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Loewe M; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., van Schooten J; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Ramos V; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Oliveira TY; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Nishimura Y; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Koranda NS; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Wall A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Global Health, University of Washington, Seattle, WA 98195, USA., Yao KH; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Poston D; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Gazumyan A; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Wiatr M; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Horning M; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Hoffmann MAG; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Yang Z; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Abernathy ME; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Dam KA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gao H; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gnanapragasam PNP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Kakutani LM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Pavlovitch-Bedzyk AJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Howarth M; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., McGuire AT; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Global Health, University of Washington, Seattle, WA 98195, USA., Stamatatos L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Global Health, University of Washington, Seattle, WA 98195, USA., Martin MA; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Nussenzweig MC; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.; Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Publikováno v: Science immunology [Sci Immunol] 2023 Feb 17; Vol. 8 (80), pp. eade6364. Date of Electronic Publication: 2023 Feb 10.