Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Koppaka V"'
Autor:
Koppaka V. Rao, James H. Johnson
Publikováno v:
Phytochemistry. 49:1361-1364
Taxiflorine, originally isolated from the needles of Taxus floridana and described previously, has its structure revised to that of taxchinin M. Four other known taxanes also isolated were: 1-deoxy baccatin IV, 1-hydroxy baccatin 1, 10-deacetyl pacli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6bc776982561949eda7f7ce7d92022d
https://doi.org/10.1016/s0031-9422(98)00089-2
https://doi.org/10.1016/s0031-9422(98)00089-2
Autor:
James H. Johnson, Koppaka V. Rao
Publikováno v:
Tetrahedron Letters. 39:4611-4614
Paclitaxel and some of its natural analogues are readily converted to their respective nitrate esters when reacted with nitric acid in acetic anhydride at 25° C in 30 minutes. Under milder conditions. partially esterified products can be prepared. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10a4c3e4b468d1b6c442eb89c91990dc
https://doi.org/10.1016/s0040-4039(98)00851-x
https://doi.org/10.1016/s0040-4039(98)00851-x
Autor:
Koppaka V. Rao
Publikováno v:
Journal of Heterocyclic Chemistry. 34:675-680
Paclitaxel, an antitumor drug effective on ovarian and breast carcinomas, is currently being produced both by direct isolation from the bark of Taxus brevifolia and by semi-synthesis from a natural precursor, 10-deacetyl baccatin III. Although other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918e3cade07395e5600aae0271e5f721
https://doi.org/10.1002/jhet.5570340255
https://doi.org/10.1002/jhet.5570340255
Publikováno v:
Phytochemistry. 43:439-442
The chloroform-soluble portion of the methanolic extract of the needles of Taxus x media was chromatographed on a C-18 reverse-phase column and the major components were separated by direct crystallization. Further fractionation by chromatography on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9186f343ded00b491e586a7cdf889caa
https://doi.org/10.1016/0031-9422(96)00281-6
https://doi.org/10.1016/0031-9422(96)00281-6
Autor:
Charles P. Rock, Koppaka V. Rao
Publikováno v:
Journal of Heterocyclic Chemistry. 33:447-458
Streptonigrin is an antitumor antibiotic with significant in vitro and in vivo antitumor activity spectrum. Besides the total syntheses, numerous syntheses of the partial structures have been carried out in order to assess the structural requirements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9642fcf2ce07523975bc19681860fd18
https://doi.org/10.1002/jhet.5570330238
https://doi.org/10.1002/jhet.5570330238
Publikováno v:
Phytochemistry. 41:863-866
Large-scale processing of the chloroform extract of the bark of Taxus brevifolia by reversed phase column chromatography on C-18 bonded silica using acetonitrile/water mixtures, gave a taxane-rich fraction which emerged just after the elution of pacl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdc4a8422009987454f3933f29d37bc
https://doi.org/10.1016/0031-9422(95)00672-9
https://doi.org/10.1016/0031-9422(95)00672-9
Publikováno v:
Journal of Medicinal Chemistry. 38:3411-3414
10-Deacetylpaclitaxel, isolated from the bark of Taxus brevifolia, was converted into paclitaxel in one composite step (trimethylsilylation, acetylation, and desilylation) and in an overall yield of 80-85%. A series of 10-monoesters of 10-deacetylpac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81591b9aef82d8697e88c898ce7c1e6
https://doi.org/10.1021/jm00017a026
https://doi.org/10.1021/jm00017a026
Autor:
Ronald Baxley, Koppaka V. Rao, Mark Stoy, Claudio Alvarez, Jampani B. Hanuman, Richard M. Davies, John Juchum
Publikováno v:
Pharmaceutical Research. 12:1003-1010
Purpose. In view of the demonstrated antitumor activity of taxol, ready availability of the drug is important. The current isolation methods starting from the bark of Taxus brevifolia involve multiple manipulations, leading to only taxol and in a yie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64c8de9ebfebaf623dac34cbc9b52628
https://doi.org/10.1023/a:1016206314225
https://doi.org/10.1023/a:1016206314225
Autor:
Koppaka V. Rao
Publikováno v:
Pharmaceutical Research. 10:521-524
The published procedures for the isolation of taxol from the Pacific yew (Taxus brevifolia) and other species of Taxus are cumbersome, and the yields of taxol are in the range of 0.0075–0.01%. This paper describes a simple and efficient procedure f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfe612f5b239551ff2ad8111d3c91492
https://doi.org/10.1023/a:1018937700459
https://doi.org/10.1023/a:1018937700459
Autor:
Koppaka V. Rao
Publikováno v:
ChemInform. 28
Paclitaxel, an antitumor drug effective on ovarian and breast carcinomas, is currently being produced both by direct isolation from the bark of Taxus brevifolia and by semi-synthesis from a natural precursor, 10-deacetyl baccatin III. Although other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0c59da2e39046a14c9a9b27a1218d46
https://doi.org/10.1002/chin.199741227
https://doi.org/10.1002/chin.199741227