Výsledky vyhledávání - "Kopf, Adrian H."

Akademický článek

Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

Autor: Yu, Zhiyi, van Veldhoven, Jacobus P.D., 't Hart, Ingrid M.E., Kopf, Adrian H., Heitman, Laura H., IJzerman, Adriaan P.

Publikováno v: In European Journal of Medicinal Chemistry 1 December 2015 106:50-59

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Synthesis and Evaluation of a Library of Alternating Amphipathic Copolymers to Solubilize and Study Membrane Proteins

Autor: Kopf, Adrian H., Lijding, Odette, Elenbaas, Barend O. W., Koorengevel, Martijn C., Dobruchowska, Justyna M., Walree, Cornelis A. van, Killian, J. Antoinette, Sub Membrane Biochemistry & Biophysics, Afd Chemical Biology and Drug Discovery, Membrane Biochemistry and Biophysics, Chemical Biology and Drug Discovery

Publikováno v: Biomacromolecules, 23(3), 743. American Chemical Society : Division of Carbohydrate Chemistry

Amphipathic copolymers such as poly(styrene-maleic acid) (SMA) are promising tools for the facile extraction of membrane proteins (MPs) into native nanodiscs. Here, we designed and synthesized a library of well-defined alternating copolymers of SMA a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4933403cc4293608fcb65211c2c7d782
https://dspace.library.uu.nl/handle/1874/417821

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Solubilization of artificial mitochondrial membranes by amphiphilic copolymers of different charge

Autor: Janson, Kevin, Zierath, Jennifer, Kyrilis, Fotis L., Semchonok, Dmitry A., Hamdi, Farzad, Skalidis, Ioannis, Kopf, Adrian H., Das, Manabendra, Kolar, Cenek, Rasche, Marie, Vargas, Carolyn, Keller, Sandro, Kastritis, Panagiotis L., Meister, Annette, Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics

Publikováno v: Biochimica et Biophysica Acta-Biomembranes, 1863(12), 1. Elsevier

Certain amphiphilic copolymers form lipid-bilayer nanodiscs from artificial and natural membranes, thereby rendering incorporated membrane proteins optimal for structural analysis. Recent studies have shown that the amphiphilicity of a copolymer stro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19e8cfb71d542ac7725fef163c3cf81
https://dspace.library.uu.nl/handle/1874/415982

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Akademický článek

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Iterative RAFT-Mediated Copolymerization of Styrene and Maleic Anhydride toward Sequence- And Length-Controlled Copolymers and Their Applications for Solubilizing Lipid Membranes

Autor: Cunningham, Randy D., Kopf, Adrian H., Elenbaas, Barend O.W., Staal, Bastiaan B.P., Pfukwa, Rueben, Killian, J. Antoinette, Klumperman, Bert, Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics

Publikováno v: Biomacromolecules, 21(8), 3287. American Chemical Society : Division of Carbohydrate Chemistry

The use of poly(styrene-co-maleic acid) (SMA) for the solubilization of lipid membranes and membrane proteins is becoming more widespread, and with this, the need increases to better understand the chemical properties of the copolymer and how these t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77383b5d176055be6a074fa74213526
https://dspace.library.uu.nl/handle/1874/409607

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Mass Photometry of Membrane Proteins

Publikováno v: Chem
Chem, 7(1), 224. Cell Press
Chem, 2021, Vol.7(1), pp.224-236 [Peer Reviewed Journal]
Chem, 7 (1)

Summary Integral membrane proteins (IMPs) are biologically highly significant but challenging to study because they require maintaining a cellular lipid-like environment. Here, we explore the application of mass photometry (MP) to IMPs and membrane-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc4ed36e4f5113a1b8e4402039e0031
https://pubmed.ncbi.nlm.nih.gov/33511302

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Factors influencing the solubilization of membrane proteins from Escherichia coli membranes by styrene–maleic acid copolymers

Autor: Kopf, Adrian H., Dörr, Jonas M., Koorengevel, Martijn C., Antoniciello, Federico, Jahn, Helene, Killian, J. Antoinette, Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics

Publikováno v: Biochimica et Biophysica Acta-Biomembranes, 1862(2). Elsevier

Styrene–maleic acid (SMA) copolymers are a promising alternative to detergents for the solubilization of membrane proteins. Here we employ Escherichia coli membranes containing KcsA as a model protein to investigate the influence of different envir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5577fda0c1a9271c44f54ce6e9c8ab
https://dspace.library.uu.nl/handle/1874/389672

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Membrane Solubilization by Styrene-Maleic Acid Copolymers: Delineating the Role of Polymer Length

Autor: Domínguez Pardo, Juan J, Koorengevel, Martijn C, Uwugiaren, Naomi, Weijers, Jeroen, Kopf, Adrian H, Jahn, Helene, van Walree, Cornelis A, van Steenbergen, Mies J, Killian, J Antoinette, Membrane Biochemistry and Biophysics, Sub Membrane Biochemistry & Biophysics, Afd Pharmaceutics, Pharmaceutics

Publikováno v: Biophysical Journal, 115(1), 129. Biophysical Society

Styrene-maleic acid (SMA) copolymers have attracted interest in membrane research because they allow the solubilization and purification of membrane-spanning proteins from biological membranes in the form of native-like nanodisks. However, our unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb17949131167fbf92bfee59686f56ed
https://dspace.library.uu.nl/handle/1874/374068

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