Zobrazeno 1 - 10 of 8 897 pro vyhledávání: '"Kopan, R"'
1
Report
Reduced Nephron Endowment in Six2-TGCtg Mice Is Due to Six3 Misexpression by Aberrant Enhancer-Promoter Interactions in the Transgene.
Autor: Perl AJ; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Liu H; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Hass M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Adhikari N; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Chaturvedi P; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Hu YC; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Jiang R; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Liu Y; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Kopan R; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2024 May 01; Vol. 35 (5), pp. 566-577. Date of Electronic Publication: 2024 Mar 06.
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2
Akademický článek
The unique functions of Runx1 in skeletal muscle maintenance and regeneration are facilitated by an ETS interaction domain.
Autor: Yu M; State Key Laboratory of Genetic Engineering, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai 200438, China., Thorner K; Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Parameswaran S; Division of Human Genetics, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Wei W; State Key Laboratory of Genetic Engineering, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai 200438, China., Yu C; State Key Laboratory of Genetic Engineering, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai 200438, China., Lin X; State Key Laboratory of Genetic Engineering, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai 200438, China., Kopan R; Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Hass MR; Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Division of Human Genetics, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Publikováno v: Development (Cambridge, England) [Development] 2024 Dec 15; Vol. 151 (24). Date of Electronic Publication: 2024 Dec 12.
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3
Akademický článek
Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity.
Autor: Dai Q; State Key Laboratory of Genetic Engineering, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China.; Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America., Preusse K; Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America., Yu D; State Key Laboratory of Genetic Engineering, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China., Kovall RA; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America., Thorner K; Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America., Lin X; State Key Laboratory of Genetic Engineering, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China., Kopan R; Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.
Publikováno v: PLoS genetics [PLoS Genet] 2024 Dec 12; Vol. 20 (12), pp. e1011486. Date of Electronic Publication: 2024 Dec 12 (Print Publication: 2024).
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4
Akademický článek
Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud.
Autor: Shi M; Division of Nephrology and Hypertension, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Crouse B; Division of Nephrology and Hypertension, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Sundaram N; Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Pode Shakked N; Division of Nephrology and Hypertension, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Current address: Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Ester L; Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA., Zhang W; Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA., Janakiram V; Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kopan R; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Helmrath MA; Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Bonventre JV; Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA., McCracken KW; Division of Nephrology and Hypertension, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Lead contact.
Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20.
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5
Akademický článek
RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis.
Autor: Pode-Shakked N; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Slack M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA., Sundaram N; Division of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA., Schreiber R; Department of Pediatrics, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel., McCracken KW; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Dekel B; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Stem Cell Research Institute and division of pediatric nephrology, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel., Helmrath M; Division of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA., Kopan R; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA. Rafi.kopan@gmail.com.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. Rafi.kopan@gmail.com.
Publikováno v: Nature communications [Nat Commun] 2023 Dec 09; Vol. 14 (1), pp. 8159. Date of Electronic Publication: 2023 Dec 09.
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6
The unique function of Runx1 in skeletal muscle differentiation and regeneration is mediated by an ETS interaction domain.
Autor: Yu M, Thorner K, Parameswaran S, Wei W, Yu C, Lin X, Kopan R, Hass MR
Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 21. Date of Electronic Publication: 2023 Nov 21.
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7
Akademický článek
Characterizing post-branching nephrogenesis in the neonatal rabbit.
Autor: Schuh MP; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Meredith.Schuh@cchmc.org.; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7022, Cincinnati, OH, 45229, USA. Meredith.Schuh@cchmc.org.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Meredith.Schuh@cchmc.org., Yarlagadda S; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7022, Cincinnati, OH, 45229, USA., Alkhudairy L; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7022, Cincinnati, OH, 45229, USA., Preusse K; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kopan R; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Publikováno v: Scientific reports [Sci Rep] 2023 Nov 06; Vol. 13 (1), pp. 19234. Date of Electronic Publication: 2023 Nov 06.
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8
Reduced nephron endowment in the common Six2-TGC tg mouse line is due to Six3 misexpression by aberrant enhancer-promoter interactions in the transgene.
Autor: Perl AJ, Liu H, Hass M, Adhikari N, Chaturvedi P, Hu YC, Jiang R, Liu Y, Kopan R
Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 09. Date of Electronic Publication: 2023 Oct 09.
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9
Akademický článek
Regulation of nephron progenitor cell lifespan and nephron endowment.
Autor: Perl AJ; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Schuh MP; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kopan R; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Raphael.Kopan@cchmc.org.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Raphael.Kopan@cchmc.org.
Publikováno v: Nature reviews. Nephrology [Nat Rev Nephrol] 2022 Nov; Vol. 18 (11), pp. 683-695. Date of Electronic Publication: 2022 Sep 14.
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10
Akademický článek
The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis.
Autor: Schuh MP; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Alkhudairy L; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Potter A; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Potter SS; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Chetal K; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Thakkar K; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, Ohio., Salomonis N; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Kopan R; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2021 May 03; Vol. 32 (5), pp. 1097-1112. Date of Electronic Publication: 2021 Mar 31.
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