Clinical Outcome in Patients with Large Sinonasal Tumors with Intracranial Extension

Autor: Max E. Keizer, Koos E. Hovinga, Martin Lacko, Danielle B.P. Eekers, Laura W.J. Baijens, Bernd Kremer, Yasin Temel

Publikováno v: Journal of Neurological Surgery Part B: Skull Base.

Objectives Malignant tumors of the sinonasal cavities with extension to the frontal skull base are rare and challenging pathologies. Combined-approach surgery using a frontobasal craniotomy and endoscopic sinus surgery with reconstruction of the ante

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3be710414c610d9655a5c2f772db9d80
https://doi.org/10.1055/a-2082-4951

Data from Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma

Autor: Henk M.W. Verheul, Connie R. Jiménez, William P. Vandertop, Thang V. Pham, Sander R. Piersma, Henk Dekker, Godefridus J. Peters, Jaco C. Knol, Alex A. Henneman, Richard de Goeij-de Haas, Richard J. Honeywell, Philip C. De Witt Hamer, Koos E. Hovinga, Cyrillo G. Brahm, Mariette Labots, Myra E. van Linde

Purpose:Tyrosine kinase inhibitors (TKI) have poor efficacy in patients with glioblastoma (GBM). Here, we studied whether this is predominantly due to restricted blood–brain barrier penetration or more to biological characteristics of GBM.Patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbdf25f191602c2463adb0ddbebdbb1
https://doi.org/10.1158/1078-0432.c.6530979

Thalamic Glioblastoma: Clinical Presentation, Management Strategies, and Outcomes

Autor: Cameron Brennan, Thomas W. Link, Natalie DiStefano, Viviane Tabar, Philip H. Gutin, Yoshua Esquenazi, Koos E. Hovinga, Nelson Moussazadeh, Anne S. Reiner

Publikováno v: Neurosurgery

Background Thalamic glioblastomas (GBMs) represent a significant neurosurgical challenge. In view of the low incidence of these tumors, outcome data and management strategies are not well defined. Objective To identify the natural history and factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d59289b598d1784436a548e8e267f4e
https://doi.org/10.1093/neuros/nyx349

Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial

Autor: Naoko Takebe, Ran Xu, Jeffrey G. Supko, J. Bryan Iorgulescu, Fumiko Shimizu, Christian Grommes, Timothy A. Chan, Sasan Karimi, Philip H. Gutin, Elena Pentsova, Craig Nolan, Nian Wu, Leif A. Droms, Lisa M. DeAngelis, Kyung K. Peck, Antonio Omuro, Dylan Bobrow, Justin R. Cross, Katherine S. Panageas, Adilia Hormigo, S. Percy Ivy, Kathryn Beal, Viviane Tabar, Thomas Kaley, Koos E. Hovinga

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 22(19)

Purpose: High-grade gliomas are associated with a dismal prognosis. Notch inhibition via the gamma-secretase inhibitor RO4929097 has emerged as a potential therapeutic option based on modulation of the cancer-initiating cell (CIS) population and a pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca04245aaf3113f4dfddd138836e679
https://pubmed.ncbi.nlm.nih.gov/27154916

Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma

Autor: Gijsbert D. Musters, Dick J. Richel, Wouter R. van Furth, Lukas J.A. Stalpers, Joost J.C. Verhoeff, William P.J. Leenders, Koos E. Hovinga, W. Peter Vandertop, An Claes

Publikováno v: European Journal of Cancer, 45, 17, pp. 3074-80
European Journal of Cancer, 45, 3074-80
European journal of cancer (Oxford, England, 45(17), 3074-3080. Elsevier Limited
European Journal of Cancer, 45(17), 3074-3080. Pergamon
Verhoeff, J J C, Stalpers, L J A, Claes, A, Hovinga, K E, Musters, G D, Peter Vandertop, W, Richel, D J, Leenders, W P J & van Furth, W R 2009, ' Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma ', European Journal of Cancer, vol. 45, no. 17, pp. 3074-3080 . https://doi.org/10.1016/j.ejca.2009.08.004

Contains fulltext : 81038.pdf (Publisher’s version ) (Closed access) AIM OF THE STUDY: Tumour angiogenesis and invasion are key features of glioblastoma multiforme (GBM). Angiogenesis inhibitors increase progression-free survival (PFS) of recurrent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477a69a2d114b79965622d17c9c12f0a
https://doi.org/10.1016/j.ejca.2009.08.004