Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction

Autor: Borgdorff, Marinus A.J., Koop, Anne Marie C., Bloks, Vincent W., Dickinson, Michael G., Steendijk, Paul, Sillje, Herman H.W., van Wiechen, Maarten P.H., Berger, Rolf M.F., Bartelds, Beatrijs

Publikováno v: In Journal of Molecular and Cellular Cardiology February 2015 79:244-253

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The adult heart requires baseline expression of the transcription factor Hand2 to withstand right ventricular pressure overload.

Autor: Videira RF; Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands.; Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands.; Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda professor Hernâni Monteiro, 4200-319 Porto, Portugal., Koop AMC; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Center for Congenital Heart Diseases, Hanzeplein 1, 9713 GZ Groningen, The Netherlands., Ottaviani L; Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands.; Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands., Poels EM; Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands., Kocken JMM; Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands.; Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands., Dos Remedios C; Department of Anatomy and Histology, University of Sidney, Sidney, NSW 2006 and Molecular Cardiology Group at Victor Chang Cardiac Research institute, Darlinghurst, NSW 2010, Australia., Mendes-Ferreira P; Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda professor Hernâni Monteiro, 4200-319 Porto, Portugal., Van De Kolk KW; University Medical Center Groningen, The Central Animal Facility, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.; University Medical Center Groningen, Gronsai (Groningen Small Animal Imaging Facility), Hanzeplein 1, 9713 GZ Groningen, The Netherlands., Du Marchie Sarvaas GJ; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Center for Congenital Heart Diseases, Hanzeplein 1, 9713 GZ Groningen, The Netherlands., Lourenço A; Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda professor Hernâni Monteiro, 4200-319 Porto, Portugal., Llucià-Valldeperas A; Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, PHEniX laboratory, Amsterdam Cardiovascular Sciences, De Boelelaan 1108, 1081HZ Amsterdam, The Netherlands., Nascimento DA; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.; INEB-Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.; ICBAS-Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal., De Windt LJ; Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands.; Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands., De Man FS; Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, PHEniX laboratory, Amsterdam Cardiovascular Sciences, De Boelelaan 1108, 1081HZ Amsterdam, The Netherlands., Falcão-Pires I; Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda professor Hernâni Monteiro, 4200-319 Porto, Portugal., Berger RMF; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Center for Congenital Heart Diseases, Hanzeplein 1, 9713 GZ Groningen, The Netherlands., da Costa Martins PA; Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands.; Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands.; Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Alameda professor Hernâni Monteiro, 4200-319 Porto, Portugal.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2022 Sep 20; Vol. 118 (12), pp. 2688-2702.