Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Koon Y. Pak"'
Autor:
Cheng Liu, Yi Li, Xiaojia Qin, Ziyi Yang, Jianmin Luo, Jianping Zhang, Brian Gray, Koon Y. Pak, Xiaoping Xu, Jingyi Cheng, Yingjian Zhang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 125, Iss , Pp 109947- (2020)
Purpose: 99mTc-duramycin imaging enables specific visualization of cell death qualitatively and quantitatively. This study aimed to investigate the potential of 99mTc-duramycin imaging in the early prediction of the curative effect of radiotherapy in
Externí odkaz:
https://doaj.org/article/f81c7f7761b445c8a06c29affb96c6b0
Autor:
Ahmet Kaynak, Harold W. Davis, Subrahmanya D. Vallabhapurapu, Koon Y. Pak, Brian D. Gray, Xiaoyang Qi
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1193 (2021)
Glioblastoma multiforme (GBM), the most common type of brain cancer, is extremely aggressive and has a dreadful prognosis. GBM comprises 60% of adult brain tumors and the 5 year survival rate of GBM patients is only 4.3%. Standard-of-care treatment i
Externí odkaz:
https://doaj.org/article/002c267e965e47ffbe8ff6e7ce906e59
Autor:
Harold W. Davis, Subrahmanya D. Vallabhapurapu, Zhengtao Chu, Michael A. Wyder, Kenneth D. Greis, Venette Fannin, Ying Sun, Pankaj B. Desai, Koon Y. Pak, Brian D. Gray, Xiaoyang Qi
Publikováno v:
Cells, Vol 9, Iss 9, p 1960 (2020)
Glioblastoma multiforme (GBM), a common type of brain cancer, has a very poor prognosis. In general, viable GBM cells exhibit elevated phosphatidylserine (PS) on their membrane surface compared to healthy cells. We have developed a drug, saposin C-di
Externí odkaz:
https://doaj.org/article/d8d42fb3d44246a289e85d2ce7e47e28
Autor:
Leonie wyffels, Brian D. Gray, Christy Barber, Koon Y. Pak, Safiyyah Forbes, Jeffrey A. Mattis, James M. Woolfenden, Zhonglin Liu
Publikováno v:
Molecular Imaging, Vol 11 (2012)
A fluorescent zinc 2,2′-dipicolylamine coordination complex PSVue®794 (probe 1) is known to selectively bind to phosphatidylserine exposed on the surface of apoptotic and necrotic cells. In this study, we investigated the cell death targeting prop
Externí odkaz:
https://doaj.org/article/19c534c81bb348be957dd4bafd0853ba
Autor:
Diego R. Martin, Li Wan, Zheng Li, James M. Woolfenden, Koon Y. Pak, Christy Barber, Brian D. Gray, Zhonglin Liu, Rongguang Liang, Lars R. Furenlid
Publikováno v:
Molecular Imaging and Biology. 25:133-143
PURPOSE Previous studies indicate that 99mTc- and fluorescent-labeled c[Cys-Thr-Pro-Ser-Pro-Phe-Ser-His-Cys]OH (TCP-1) peptides were able to detect colorectal cancer (CRC) and tumor-associated vasculature. This study was designed to characterize the
Autor:
Anne Rix, Anna Mrugalla, Natascha Drude, E. Fiegle, Fabian Kiessling, Brian D. Gray, Koon Y. Pak, Felix M. Mottaghy, Wiltrud Lederle, Rene Tolba, H.-J. Kaiser, F. Baskaya
Publikováno v:
Molecular Imaging and Biology, 22(3), 623-633. Springer
PURPOSE: Evaluation of [68Ga]NODAGA-duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity.PROCEDURES: Tracer specificity of Ga-68 labeled NODAGA-duramycin was determined
Autor:
Phillip D. Levy, Farhan Chaudhry, Jinhua Liu, Hideki Kawai, Peter S. Heeger, Jeffrey A. Mattis, Navneet Narula, Matthew K.M.Y. Adapoe, Andre L. Moreira, Aditya Shekhar, Yansui Li, Kipp W. Johnson, H. William Strauss, Jagat Narula, Koon Y. Pak, Julian K. Horwitz, Artiom Petrov
Publikováno v:
JACC: Cardiovascular Imaging. 13:1438-1441
About 5,400 heart transplantations are performed around the world annually. Survival in allograft recipients has improved substantially over the years with effective immunosuppressive therapy. However, acute cellular or antibody-mediated allograft re
Autor:
Xiaoyang Qi, Subrahmanya D. Vallabhapurapu, Brian D. Gray, Harold W. Davis, Ahmet Kaynak, Koon Y. Pak
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1193, p 1193 (2021)
Pharmaceuticals
Pharmaceuticals
Glioblastoma multiforme (GBM), the most common type of brain cancer, is extremely aggressive and has a dreadful prognosis. GBM comprises 60% of adult brain tumors and the 5 year survival rate of GBM patients is only 4.3%. Standard-of-care treatment i
Autor:
Meghana V. Bapardekar, Gautam N Shenoy, Leonard D. Shultz, Gerald P. Linette, Koon Y. Pak, Sathy V. Balu-Iyer, Richard B. Bankert, Maulasri Bhatta, Hans Minderman, Jenni L Loyall, Brian D. Gray, Alexis Conway, Beatriz M. Carreno, Kunle Odunsi, Raymond J. Kelleher
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
BackgroundThe human tumor microenvironment (TME) is a complex and dynamic milieu of diverse acellular and cellular components, creating an immunosuppressive environment, which contributes to tumor progression. We have previously shown that phosphatid
Publikováno v:
ACS sensors. 6(10)
Surgical resection of cancerous tissues is a critical procedure for solid tumor treatment. During the operation, the surgeon mostly identifies the cancerous tissues by naked-eye visualization under white light without aid, therefore, the outcome heav