Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kook Heon Seo"'
Autor:
Hae-Kyong Back, Kyoung-Jin Kim, Han-A Kim, Yeong-Rim Kang, Suhn-Young Im, Kook Heon Seo, Hern-Ku Lee, Hyun-Mi Ko
Publikováno v:
Cellular Physiology and Biochemistry. 27:55-62
It has been previously reported that platelet-activating factor (PAF) induces the expression of vascular endothelial growth factor (VEGF) via the downregulation of p53 activity. In this study, we attempted to characterize the mechanism by which p53 a
Autor:
Jianrui Xu, Dong Mei Meng, Rafal Pacholczyk, Kook Heon Seo, Li Zhou, Qing-Sheng Mi, Hong Zhi He, Chang Gui Li, Jin-Xiong She, Zheng Dong
Publikováno v:
Proceedings of the National Academy of Sciences. 106:10266-10271
MicroRNAs (miRNAs) are a class of evolutionarily conserved small noncoding RNAs that are increasingly being recognized as important regulators of gene expression. The ribonuclease III enzyme Dicer is essential for the processing of miRNAs. CD1d-restr
Publikováno v:
Immunity. 27:334-348
gammadelta T cells are important contributors to innate immunity against cancer, but their regulatory role in controlling immune responses remains largely unknown. Here we report that a dominant gammadelta1 T cell population among lymphocytes infiltr
Autor:
Han-A Kim, Hern-Ku Lee, Kook Heon Seo, Hae Hyun Jung, Sung Jun Park, Hyun-Mi Ko, Yeong-Rim Kang, Suhn-Young Im
Publikováno v:
FEBS Letters. 580:3006-3012
We investigated the role of p53 in nuclear factor (NF)-kappaB dependent, platelet-activating factor (PAF)-induced vascular endothelial growth factor (VEGF) expression. Transfected NF-kappaB subunits in ECV304 cells increased the tumor necrosis factor
Autor:
Jung-Hwa Choi, Hae Hyun Jung, Hern-Ku Lee, Il-Whan Choi, Suhn-Young Im, Young Hyun Chun, Kook Heon Seo, Hyun-Mi Ko
Publikováno v:
European Journal of Immunology. 34:2129-2137
Activated monocyte-macrophages have been implicated in tumor angiogenesis via their capacity to produce many potent angiogenic factors. However, the mechanisms leading to production of these angiogenic factors in macrophages remain to be elucidated.
Autor:
Jin Hee Park, Kook Heon Seo, Suhn Young Im, Jin-Man Kim, Cheol Yi Hong, Hueng Sik Choi, Keesook Lee, Jae Woon Lee
Publikováno v:
Molecular and Cellular Biology. 23:6000-6012
The expression of Mullerian inhibiting substance (MIS), a key molecule in sex differentiation and reproduction, is tightly regulated. It has been suggested that meiotic germ cells repress MIS expression in testicular Sertoli cells, although the subst
Autor:
Shun-Young Im, Keun-Sang Kwon, Tai-You Ha, Young-Suk Kim, Jung-Hwa Choi, Myung-Shik Lee, Il-Whan Choi, Dae-Ki Kim, Hern-Ku Lee, Kook-Heon Seo
Publikováno v:
The Journal of Experimental Medicine
Anaphylaxis is a life-threatening systemic allergic reaction with the potential for a recurrent or biphasic pattern. Despite an incidence of biphasic reaction between 5 and 20%, the molecular mechanism for the reaction is unknown. Using a murine mode
Molecular Mechanisms for Lipopolysaccharide-induced Biphasic Activation of Nuclear Factor-κB (NF-κB)
Autor:
Jung-Hwa Choi, Il-Whan Choi, Su-Ji Han, Hyun-Mi Ko, Hyun-Suk Lee, Eun Kyoung Choi, Suhn-Young Im, Kook Heon Seo, Hern-Ku Lee
Publikováno v:
Journal of Biological Chemistry. 277:44715-44721
The nuclear factor-kappaB (NF-kappaB) is an important transcription factor necessary for initiating and sustaining inflammatory and immune reactions. The inducers of NF-kappaB are well characterized, but the molecular mechanisms underlying multiple i
Autor:
Kook Heon Seo, Kyung Keun Kim, Choon Sang Bae, Jong-Keun Kim, Zang Hee Lee, Kyu Youn Ahn, Hong-Hee Kim
Publikováno v:
Molecular Brain Research. 75:237-247
Refsum disease is an autosomal recessive neurologic disorder of the lipid metabolism. Major diagnostic clinical findings include retinitis pigmentosa, peripheral polyneuropathy, cerebellar ataxia, increased cerebrospinal fluid protein without pleocyt
Publikováno v:
Cellular immunology. 285(1-2)
The mechanisms of mucosal immunogenicity and adjuvanticity of bacterial exotoxins remains unknown. In this study, we investigated the role of the transcription factor nuclear factor-κB (NF-κB) in cholera toxin (CT)-induced alteration of oral tolera