Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Kooji Kagara"'
1
Effect of Seed Size on Crystallization Behavior of MPPO
Autor: Kooji Kagara, Yoshitaka Nakata, Youko Kiyosawa, Masakuni Matsuoka
Publikováno v: Organic Process Research & Development. 14:369-374
Based on our recent study on the batch crystallization of polymorphic mixture of 4-(1-(2-(3-methoxyphenethyl)phenoxy)-3-(dimethylamino)propan-2-yloxy)-4-oxobutanoic acid (MPPO), in which the polymo...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::907807c0979fe411749b34ba90a82cc2
https://doi.org/10.1021/op900289u
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3
Crystallization Behavior of Polymorphic Mixtures of MPPO
Autor: Yoshitaka Nakata, Youko Kiyosawa, Masakuni Matsuoka, Kooji Kagara
Publikováno v: Organic Process Research & Development. 13:1364-1369
4-(1-(2-(3-Methoxyphenethyl)phenoxy)-3-(dimethylamino)propan-2-yloxy)-4-oxobutanoic acid (MPPO), a serotonin receptor blocker, is known to have two polymorphs, Form A and Form B. Crystallization of MPPO was carried out from aqueous 2-butanone solutio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a0a7e63f491e84c74453353ba453ef2
https://doi.org/10.1021/op900220m
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4
Production of Spherical Agglomerates of Cephalosporin Antibiotic Crystals
Autor: Keiichi Koga, Hiroshi Ooshima, Takashi Mukuta, Shigeru Moriki, Koji Machiya, Kooji Kagara
Publikováno v: JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 41:1017-1023
A cephalosporin antibiotic, PATC (5-Amino-2-[((6R,7R)-7-{(2Z)-2-(5-amino-1,2,4- thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetylamino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-(2-hydroxyethyl)-1H-pyrazol-2-iumchlori
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9735f8992ea0d12b85ee19dd9b8dafc
https://doi.org/10.1252/jcej.08we178
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5
The Process Development of a Novel Aldose Reductase Inhibitor, FK366. Part 1. Improvement of Discovery Process and New Syntheses of 1-Substituted Quinazolinediones
Autor: Kooji Kagara, Shunsuke Goto, Masami Kanoda, Koji Mukai, Hiroyuki Tsuboi
Publikováno v: Organic Process Research & Development. 7:700-706
This contribution describes part 1 of process development of a novel aldose reductase inhibitor FK366 (1). The original process applied on a laboratory scale was improved from the safety viewpoint to manufacture materials on 500-L scale suitable for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5aacfefea32235ed9a56eed7709321ce
https://doi.org/10.1021/op0340661
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6
Control of Hydrates of Vamicamide Hydrochloride
Autor: Takashi Mukuta, Takanori Kawai, Eiki Oikawa, Kooji Kagara
Publikováno v: KAGAKU KOGAKU RONBUNSHU. 29:734-739
バミカミド塩酸塩にはA形晶（1水和物），B形晶（1.5水和物），C形晶（2水和物），D形晶（3水和物）の水和物結晶が存在する．これら水和物結晶の粉体特性および晶析挙動を調べ，濾過性
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f36e6d763eab7d47b236dd69c970550d
https://doi.org/10.1252/kakoronbunshu.29.734
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7
Process Development of Vamicamide (FK176)
Autor: Masaharu Ichihara, Kooji Kagara, Shunsuke Goto
Publikováno v: Journal of Synthetic Organic Chemistry, Japan. 57:415-421
Vamicamide is a new anticholinergic agent useful for the treatment of urinary incontinence. Vamicamide is synthesized from benzonitrile in 6 steps which include reductive amination and separation of diastereomers as key steps. In this paper, the proc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b2ddb434b6ddd4d5c9d50b7f123b871
https://doi.org/10.5059/yukigoseikyokaishi.57.415
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8
Optical Resolution of Imidazole Compound by Preferential Dissolution Method
Autor: Kooji Kagara, Takashi Nakamura, Nobutaka Kawai, Koji Machiya
Publikováno v: KAGAKU KOGAKU RONBUNSHU. 23:618-623
イミダゾール体をエタノール水溶液中で, L-10-カンファースルホン酸と塩を形成させて光学分割する際に, 最少量の溶媒から両異性体の塩を結晶として充分析出させた後に, 少量の溶媒を
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b17e470763d917ea1054208fa4220975
https://doi.org/10.1252/kakoronbunshu.23.618
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10
Control of Polymorphism in Trialkylurea
Autor: Shigeru Ieda, Kooji Kagara, Muneharu Ikushima, Hironobu Yasuda, Shunsuke Goto
Publikováno v: KAGAKU KOGAKU RONBUNSHU. 21:257-264
トリアルキルウレアには安定形のA形晶, 準安定形のB形晶と不安定形のC形晶が存在する.準安定形のB形晶を製造するために, 本化合物のトルエン中での晶析挙動をIRを用いて調べた.晶析温
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09149c93f20fcdb5c4c7a02388acbba2
https://doi.org/10.1252/kakoronbunshu.21.257
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