Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons

Autor: Lindhout, Feline W., Portegies, Sybren, Kooistra, Robbelien, Herstel, Lotte J., Stucchi, Riccardo, Hummel, Jessica J.A., Scheefhals, Nicky, Katrukha, Eugene A., Altelaar, Maarten, MacGillavry, Harold D., Wierenga, Corette J., Hoogenraad, Casper C.

Axon formation critically relies on local microtubule remodeling and marks the first step in establishing neuronal polarity. However, the function of the microtubule-organizing centrosomes during the onset of axon formation is still under debate. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______101::fab66d9eb85435dcd8d6708320c08166
https://dspace.library.uu.nl/handle/1874/412865

Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity

Autor: He, Liu, Kooistra, Robbelien, Das, Ravi, Oudejans, Ellen, van Leen, Eric, Ziegler, Johannes, Portegies, Sybren, de Haan, Bart, Altena, Anna van Regteren, Stucchi, Riccardo, Altelaar, A. F.Maarten, Wieser, Stefan, Krieg, Michael, Hoogenraad, Casper C., Harterink, Martin, Sub Cell Biology, Afd Biomol.Mass Spect. and Proteomics, Celbiologie, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: eLife, Vol 9 (2020)
eLife, 9. eLife Sciences Publications
eLife
elife

The development of a polarized neuron relies on the selective transport of proteins to axons and dendrites. Although it is well known that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its specific organizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10f10ad956d9c7266dd14e1ddc530c3
https://dspace.library.uu.nl/handle/1874/408848

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Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity.

Autor: He L; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands., Kooistra R; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands., Das R; Neurophotonics and Mechanical Systems Biology, ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain., Oudejans E; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands., van Leen E; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands., Ziegler J; Fast live-cell superresolution microscopy, ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain., Portegies S; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands., de Haan B; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands., van Regteren Altena A; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands., Stucchi R; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands.; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands., Altelaar AM; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands., Wieser S; Fast live-cell superresolution microscopy, ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain., Krieg M; Neurophotonics and Mechanical Systems Biology, ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain., Hoogenraad CC; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands.; Department of Neuroscience, Genentech, Inc, South San Francisco, United States., Harterink M; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands.

Publikováno v: ELife [Elife] 2020 Apr 15; Vol. 9. Date of Electronic Publication: 2020 Apr 15.