The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.

Autor: Zhou N; Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA.; Program in Bioinformatics and Computational Biology, Ames, IA, USA., Jiang Y; Indiana University Bloomington, Bloomington, Indiana, USA., Bergquist TR; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA., Lee AJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA., Kacsoh BZ; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Department of Molecular and Systems Biology, Hanover, NH, USA., Crocker AW; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Lewis KA; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Georghiou G; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom., Nguyen HN; Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA.; Program in Computer Science, Ames, IA, USA., Hamid MN; Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA.; Program in Bioinformatics and Computational Biology, Ames, IA, USA., Davis L; Program in Bioinformatics and Computational Biology, Ames, IA, USA., Dogan T; Department of Computer Engineering, Hacettepe University, Ankara, Turkey.; European Molecular Biolo gy Labora tory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Atalay V; Department of Computer Engineering, Middle East Technical University (METU), Ankara, Turkey., Rifaioglu AS; Department of Computer Engineering, Middle East Technical University (METU), Ankara, Turkey.; Department of Computer Engineering, Iskenderun Technical University, Hatay, Turkey., Dalkıran A; Department of Computer Engineering, Middle East Technical University (METU), Ankara, Turkey., Cetin Atalay R; CanSyL, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey., Zhang C; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Hurto RL; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA., Freddolino PL; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA., Zhang Y; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA., Bhat P; Achira Labs, Bangalore, India., Supek F; Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Fernández JM; INB Coordination Unit, Life Sciences Department, Barcelona Supercomputing Center, Barcelona, Catalonia, Spain.; (former) INB GN2, Structural and Computational Biology Programme, Spanish National Cancer Research Centre, Barcelona, Catalonia, Spain., Gemovic B; Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia., Perovic VR; Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia., Davidović RS; Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia., Sumonja N; Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia., Veljkovic N; Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia., Asgari E; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering, University of California Berkeley, Berkeley, CA, USA.; Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Berkeley, CA, USA., Mofrad MRK; Departments of Bioengineering and Mechanical Engineering, Berkeley, CA, USA., Profiti G; Bologna Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.; National Research Council, IBIOM, Bologna, Italy., Savojardo C; Bologna Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Martelli PL; Bologna Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Casadio R; Bologna Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Boecker F; University of Bonn: INRES Crop Bioinformatics, Bonn, North Rhine-Westphalia, Germany., Schoof H; INRES Crop Bioinformatics, University of Bonn, Bonn, Germany., Kahanda I; Gianforte School of Computing, Montana State University, Bozeman, Montana, USA., Thurlby N; University of Bristol, Computer Science, Bristol, Bristol, United Kingdom., McHardy AC; Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Brunswick, Germany.; RESIST, DFG Cluster of Excellence 2155, Brunswick, Germany., Renaux A; Interuniversity Institute of Bioinformatics in Brussels, Université libre de Bruxelles - Vrije Universiteit Brussel, Brussels, Belgium.; Machine Learning Group, Université libre de Bruxelles, Brussels, Belgium.; Artificial Intelligence lab, Vrije Universiteit Brussel, Brussels, Belgium., Saidi R; European Molecular Biolo gy Labora tory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Gough J; MRC Laboratory of Molecular Biology, Cambridge, United Kingdom., Freitas AA; University of Kent, School of Computing, Canterbury, United Kingdom., Antczak M; School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom., Fabris F; University of Kent, School of Computing, Canterbury, United Kingdom., Wass MN; School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom., Hou J; University of Missouri, Computer Science, Columbia, Missouri, USA.; Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO, USA., Cheng J; Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO, USA., Wang Z; University of Miami, Coral Gables, Florida, USA., Romero AE; Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, Egham, Surrey, United Kingdom., Paccanaro A; Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, Egham, Surrey, United Kingdom., Yang H; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Galway, Ireland.; Technical University of Munich, Garching, Germany., Goldberg T; Department of Informatics, Bioinformatics & Computational Biology-i12, Technische Universitat Munchen, Munich, Germany., Zhao C; Faculty for Informatics, Garching, Germany.; Department for Bioinformatics and Computational Biology, Garching, Germany.; School of Computing Sciences and Computer Engineering, Hattiesburg, Mississippi, USA., Holm L; Institute of Biotechnology, Helsinki Institute of Life Sciences, University of Helsinki, Finland, Helsinki, Finland., Törönen P; Institute of Biotechnology, Helsinki Institute of Life Sciences, University of Helsinki, Finland, Helsinki, Finland., Medlar AJ; Institute of Biotechnology, Helsinki Institute of Life Sciences, University of Helsinki, Finland, Helsinki, Finland., Zosa E; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Borukhov I; Compugen Ltd., Holon, Israel., Novikov I; Baylor College of Medicine, Department of Biochemistry and Molecular Biology, Houston, TX, USA., Wilkins A; Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA., Lichtarge O; Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA., Chi PH; National TsingHua University, Hsinchu, Taiwan., Tseng WC; Department of Electrical Engineering in National Tsing Hua University, Hsinchu City, Taiwan., Linial M; The Hebrew University of Jerusalem, Jerusalem, Israel., Rose PW; University of California San Diego, San Diego Supercomputer Center, La Jolla, California, USA., Dessimoz C; Department of Computational Biology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.; Department of Genetics, Evolution & Environment, and Department of Computer Science, University College London, London, UK.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Vidulin V; Department of Knowledge Technologies, Jozef Stefan Institute, Ljubljana, Slovenia., Dzeroski S; Jozef Stefan Institute, Ljubljana, Slovenia.; Jozef Stefan International Postgraduate School, Ljubljana, Slovenia., Sillitoe I; Research Department of Structural and Molecular Biology, University College London, London, England., Das S; Research Department of Structural and Molecular Biology, University College London, London, United Kingdom., Lees JG; Research Department of Structural and Molecular Biology, University College London, London, United Kingdom.; Department of Health and Life Sciences, Oxford Brookes University, London, UK., Jones DT; The Francis Crick Institute, Biomedical Data Science Laboratory, London, United Kingdom.; Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, United Kingdom., Wan C; Department of Computer Science, University College London, London, United Kingdom.; The Francis Crick Institute, Biomedical Data Science Laboratory, London, United Kingdom., Cozzetto D; Department of Computer Science, University College London, London, United Kingdom.; The Francis Crick Institute, Biomedical Data Science Laboratory, London, United Kingdom., Fa R; Department of Computer Science, University College London, London, United Kingdom.; The Francis Crick Institute, Biomedical Data Science Laboratory, London, United Kingdom., Torres M; Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, Egham, Surrey, United Kingdom., Warwick Vesztrocy A; Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, United Kingdom.; SIB Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Rodriguez JM; Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Tress ML; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Frasca M; Università degli Studi di Milano - Computer Science Department - AnacletoLab, Milan, Milan, Italy., Notaro M; Università degli Studi di Milano - Computer Science Department - AnacletoLab, Milan, Milan, Italy., Grossi G; Università degli Studi di Milano - Computer Science Department - AnacletoLab, Milan, Milan, Italy., Petrini A; Università degli Studi di Milano - Computer Science Department - AnacletoLab, Milan, Milan, Italy., Re M; Università degli Studi di Milano - Computer Science Department - AnacletoLab, Milan, Milan, Italy., Valentini G; Università degli Studi di Milano - Computer Science Department - AnacletoLab, Milan, Milan, Italy., Mesiti M; Università degli Studi di Milano - Computer Science Department - AnacletoLab, Milan, Milan, Italy.; Institut de Biologie Computationnelle, LIRMM, CNRS-UMR 5506, Universite de Montpellier, Montpellier, France., Roche DB; Department of Informatics, Bioinformatics and Computational Biology-i12, Technische Universitat Munchen, Munich, Germany., Reeb J; Department of Informatics, Bioinformatics and Computational Biology-i12, Technische Universitat Munchen, Munich, Germany., Ritchie DW; University of Lorraine, CNRS, Inria, LORIA, Nancy, 54000, France., Aridhi S; University of Lorraine, CNRS, Inria, LORIA, Nancy, 54000, France., Alborzi SZ; University of Lorraine, CNRS, Inria, LORIA, Nancy, 54000, France.; Inria, Nancy, France., Devignes MD; University of Lorraine, CNRS, Inria, LORIA, Nancy, 54000, France.; University of Lorraine, Nancy, Lorraine, France.; Inria, Nancy, France., Koo DCE; Department of Biology, New York University, New York, NY, USA., Bonneau R; NYU Center for Data Science, New York, 10010, NY, USA.; Flatiron Institute, CCB, New York, 10010, NY, USA., Gligorijević V; Center for Computational Biology (CCB), Flatiron Institute, Simons Foundation, New York, New York, USA., Barot M; Center for Data Science, New York University, New York, 10011, NY, USA., Fang H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Toppo S; Department of Molecular Medicine, University of Padova, Padova, Italy., Lavezzo E; Department of Molecular Medicine, University of Padova, Padova, Italy., Falda M; Department of Biology, University of Padova, Padova, Italy., Berselli M; Department of Molecular Medicine, University of Padova, Padova, Italy., Tosatto SCE; CNR Institute of Neuroscience, Padova, Italy.; Department of Biomedical Sciences, University of Padua, Padova, Italy., Carraro M; Department of Biomedical Sciences, University of Padua, Padova, Italy., Piovesan D; Department of Biomedical Sciences, University of Padua, Padova, Italy., Ur Rehman H; Department of Computer Science, National University of Computer and Emerging Sciences, Peshawar, Khyber Pakhtoonkhwa, Pakistan., Mao Q; Department of Computer and Information Sciences, Temple University, Philadelphia, PA, USA.; University of California, Riverside, Philadelphia, PA, USA., Zhang S; Department of Computer and Information Sciences, Temple University, Philadelphia, PA, USA., Vucetic S; Department of Computer and Information Sciences, Temple University, Philadelphia, PA, USA., Black GS; Department of Biology, Brigham Young University, Provo, UT, USA.; Bioinformatics Research Group, Provo, UT, USA., Jo D; Department of Biology, Brigham Young University, Provo, UT, USA.; Bioinformatics Research Group, Provo, UT, USA., Suh E; Department of Biology, Brigham Young University, Provo, UT, USA., Dayton JB; Department of Biology, Brigham Young University, Provo, UT, USA.; Bioinformatics Research Group, Provo, UT, USA., Larsen DJ; Department of Biology, Brigham Young University, Provo, UT, USA.; Bioinformatics Research Group, Provo, UT, USA., Omdahl AR; Department of Biology, Brigham Young University, Provo, UT, USA.; Bioinformatics Research Group, Provo, UT, USA., McGuffin LJ; School of Biological Sciences, University of Reading, Reading, England, United Kingdom., Brackenridge DA; School of Biological Sciences, University of Reading, Reading, England, United Kingdom., Babbitt PC; Department of Pharmaceutical Chemistry, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 94158, CA, USA., Yunes JM; UC Berkeley - UCSF Graduate Program in Bioengineering, University of California, San Francisco, 94158, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 94158, CA, USA., Fontana P; Research and Innovation Center, Edmund Mach Foundation, San Michele all'Adige, Italy., Zhang F; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, Shanghai, China.; Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, Shanghai, China., Zhu S; School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China.; Institute of Science and Technology for Brain-Inspired Intelligence and Shanghai Institute of Artificial Intelligence Algorithms, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China., You R; School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China.; Institute of Science and Technology for Brain-Inspired Intelligence and Shanghai Institute of Artificial Intelligence Algorithms, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China., Zhang Z; School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China., Dai S; School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China., Yao S; School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China.; Institute of Science and Technology for Brain-Inspired Intelligence and Shanghai Institute of Artificial Intelligence Algorithms, Fudan University, Shanghai, China., Tian W; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, Shanghai, China.; Department of Pediatrics, Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Cao R; Department of Computer Science, Pacific Lutheran University, Tacoma, WA, USA., Chandler C; Department of Computer Science, Pacific Lutheran University, Tacoma, WA, USA., Amezola M; Department of Computer Science, Pacific Lutheran University, Tacoma, WA, USA., Johnson D; Department of Computer Science, Pacific Lutheran University, Tacoma, WA, USA., Chang JM; Department of Computer Science, National Chengchi University, Taipei, Taiwan., Liao WH; Department of Computer Science, National Chengchi University, Taipei, Taiwan., Liu YW; Department of Computer Science, National Chengchi University, Taipei, Taiwan., Pascarelli S; Okinawa Institute of Science and Technology, Tancha, Okinawa, Japan., Frank Y; Tel Aviv University, Tel Aviv, Israel., Hoehndorf R; Computer, Electrical and Mathematical Sciences & Engineering Division, Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Jeddah, Saudi Arabia., Kulmanov M; Computer, Electrical and Mathematical Sciences & Engineering Division, Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Jeddah, Saudi Arabia., Boudellioua I; Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.; Computer, Electrical and Mathematical Sciences Engineering Division (CEMSE), King Abdullah University of Science and Technology, Thuwal, Saudi Arabia., Politano G; Control and Computer Engineering Department, Politecnico di Torino, Torino, TO, Italy., Di Carlo S; Control and Computer Engineering Department, Politecnico di Torino, Torino, TO, Italy., Benso A; Control and Computer Engineering Department, Politecnico di Torino, Torino, TO, Italy., Hakala K; Department of Future Technologies, Turku NLP Group, University of Turku, Turku, Finland.; University of Turku Graduate School (UTUGS), Turku, Finland., Ginter F; Department of Future Technologies, Turku NLP Group, University of Turku, Turku, Finland.; University of Turku, Turku, Finland., Mehryary F; Department of Future Technologies, Turku NLP Group, University of Turku, Turku, Finland.; University of Turku Graduate School (UTUGS), Turku, Finland., Kaewphan S; Department of Future Technologies, Turku NLP Group, University of Turku, Turku, Finland.; University of Turku Graduate School (UTUGS), Turku, Finland.; Turku Centre for Computer Science (TUCS), Turku, Finland., Björne J; Department of Future Technologies, Faculty of Science and Engineering, University of Turku, Turku, FI-20014, Finland.; Turku Centre for Computer Science (TUCS), Agora, Vesilinnantie 3, Turku, FI-20500, Finland., Moen H; University of Turku, Turku, Finland., Tolvanen MEE; Department of Future Technologies, University of Turku, Turku, Finland., Salakoski T; Department of Future Technologies, Faculty of Science and Engineering, University of Turku, Turku, FI-20014, Finland.; Turku Centre for Computer Science (TUCS), Agora, Vesilinnantie 3, Turku, FI-20500, Finland., Kihara D; Department of Biological Sciences, Department of Computer Science, Purdue University, 47907, IN, USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, 45229, OH, USA., Jain A; Department of Computer Science, Purdue University, West Lafayette, IN, USA., Šmuc T; Division of Electronics, Rudjer Boskovic Institute, Zagreb, Croatia., Altenhoff A; Department of Computer Science, ETH Zurich, Zurich, Switzerland.; SIB Swiss Institute of Bioinformatics, Zurich, Switzerland., Ben-Hur A; Department of Computer Science, Colorado State University, Fort Collins, CO, USA., Rost B; Department of Informatics, Bioinformatics & Computational Biology-i12, Technische Universitat Munchen, Munich, Germany.; Institute for Food and Plant Sciences WZW, Technische Universität München, Freising, Germany., Brenner SE; University of California, Berkeley, CA, USA., Orengo CA; Research Department of Structural and Molecular Biology, University College London, London, United Kingdom., Jeffery CJ; Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA., Bosco G; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Hogan DA; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Martin MJ; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom., O'Donovan C; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom., Mooney SD; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA., Greene CS; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Philadelphia, Pennsylvania, USA., Radivojac P; Khoury College of Computer Sciences, Northeastern University, Boston, MA, USA. predrag@northeastern.edu., Friedberg I; Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA. idoerg@iastate.edu.

Publikováno v: Genome biology [Genome Biol] 2019 Nov 19; Vol. 20 (1), pp. 244. Date of Electronic Publication: 2019 Nov 19.