Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo

Autor: Konxhe Kulaj, Alexandra Harger, Michaela Bauer, Özüm S. Caliskan, Tilak Kumar Gupta, Dapi Menglin Chiang, Edward Milbank, Josefine Reber, Angelos Karlas, Petra Kotzbeck, David N. Sailer, Francesco Volta, Dominik Lutter, Sneha Prakash, Juliane Merl-Pham, Vasilis Ntziachristos, Hans Hauner, Michael W. Pfaffl, Matthias H. Tschöp, Timo D. Müller, Stefanie M. Hauck, Benjamin D. Engel, Jantje M. Gerdes, Paul T. Pfluger, Natalie Krahmer, Kerstin Stemmer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Extracellular vesicles (EVs) convey inter-organ communication in health and disease. Here, the authors report that adipocyte-derived EVs isolated from insulin-resistant obese but not lean male mice stimulate insulin secretion via the targeted transfe

Externí odkaz: https://doaj.org/article/7a980c15ae974d7993862a2be969cbb9

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Autor: Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber, Alex Harger, Mostafa Bakhti, Aimee Bastidas-Ponce, Eric Baugé, Jonathan E. Campbell, Megan Capozzi, Christoffer Clemmensen, Gustav Collden, Perla Cota, Jon Douros, Daniel J. Drucker, Barent DuBois, Annette Feuchtinger, Cristina Garcia-Caceres, Gerald Grandl, Nathalie Hennuyer, Stephan Herzig, Susanna M. Hofmann, Patrick J. Knerr, Konxhe Kulaj, Fanny Lalloyer, Heiko Lickert, Arek Liskiewicz, Daniela Liskiewicz, Gandhari Maity, Diego Perez-Tilve, Sneha Prakash, Miguel A. Sanchez-Garrido, Qian Zhang, Bart Staels, Natalie Krahmer, Richard D. DiMarchi, Matthias H. Tschöp, Brian Finan, Timo D. Müller

Publikováno v: Quarta, C, Stemmer, K, Novikoff, A, Yang, B, Klingelhuber, F, Harger, A, Bakhti, M, Bastidas-Ponce, A, Baugé, E, Campbell, J E, Capozzi, M, Clemmensen, C, Collden, G, Cota, P, Douros, J, Drucker, D J, DuBois, B, Feuchtinger, A, Garcia-Caceres, C, Grandl, G, Hennuyer, N, Herzig, S, Hofmann, S M, Knerr, P J, Kulaj, K, Lalloyer, F, Lickert, H, Liskiewicz, A, Liskiewicz, D, Maity, G, Perez-Tilve, D, Prakash, S, Sanchez-Garrido, M A, Zhang, Q, Staels, B, Krahmer, N, DiMarchi, R D, Tschöp, M H, Finan, B & Müller, T D 2022, ' GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice ', Nature Metabolism, vol. 4, no. 8, pp. 1071-1083 . https://doi.org/10.1038/s42255-022-00617-6
Nature Metabolism
Nat. Metab. 4, 1071-1083 (2022)

Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPARɑ/ɣ) have beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to potential adv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8cb25c43d6de39a162496e77b8cbe0
https://pubmed.ncbi.nlm.nih.gov/35995998

The Glucose-Dependent Insulinotropic Polypeptide (GIP) Regulates Body Weight and Food Intake Via CNS-GIPR Signaling

Autor: Diego Perez-Tilve, Kerstin Stemmer, Christian Wolfrum, Xue Liu, Qian Zhang, Susanna M. Hofmann, Cassie Lynn Hollemann, Heiko Lickert, Brian Finan, Marta Tarquis Medina, Gustav Collden, Patrick J. Knerr, Emilija Malogajski, Matthias H. Tschöp, Mostafa Bakhti, Daniel J. Drucker, Laura Sehrer, Cristina Garcia Caceres, Ciro Salinno, Stephanie A. Mowery, Andreas Parzefall, Gerald Grandl, Annette Feuchtinger, Timo Dirk Müller, Challa Tenagne Delessa, Richard D. DiMarchi, Alexandra Harger, Maximilian Kleinert, Robert Augustin, Konxhe Kulaj, Beata Legutko, Gerd Luippold

Publikováno v: SSRN Electronic Journal.

Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR) should be activated or inhibited for the treatment of obesity. Gipr was recently demonstrated in hypothalamic feeding centers, but the physiological rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f79aeb9542d6bf63e1a383daa8faa6b4
https://doi.org/10.2139/ssrn.3667144