Výsledky vyhledávání - "Konstantinova Im"

Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis

Autor: Alex Azhayev, Tuomo A. Keinänen, Mervi T. Hyvönen, Elena S. Matyugina, Anastasia L. Khandazhinskaya, Maria I. Kharitonova, Konstantinova Im, Vladimir Barai, Katherine L. Seley-Radtke, Sergey N. Kochetkov, Barbara Z. Eletskaya, Ilja V. Fateev, Alex R. Khomutov

Publikováno v: Organicbiomolecular chemistry. 19(34)

Nucleoside analogues have long served as key chemotherapeutic drugs for the treatment of viral infections and cancers. Problems associated with the development of drug resistance have led to a search for the design of nucleosides capable of bypassing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ae17770268059e11cd7279ac794e75
https://pubmed.ncbi.nlm.nih.gov/34198312

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Reprogramming of nuclear proteasomes under apoptosis induction in K562 cells II. Effect of antitumor drug doxorubicin

Autor: I. V. Kozhukharova, A. S. Tsimokha, Konstantinova Im, Yu. B. Ermolaeva, Evteeva In, Mittenberg Ag, Valentina A. Kulichkova

Publikováno v: Cell and Tissue Biology. 1:404-411

The induction of apoptosis in K562 cells by doxorbuicin was used as a model for studying changes of the subunit composition, phosphorylation state, and enzymatic activities of nuclear proteasomes undergoing programmed cell death. The proteasomes isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3810c178c060656cf0bd7cc3946bfcaf
https://doi.org/10.1134/s1990519x07050057

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Reprogramming of nuclear proteasomes under apoptosis induction in K562 cells I. Effect of glutathione-depleting agent diethylmaleate

Autor: Valentina A. Kulichkova, Evteeva In, L. N. Gause, Moiseeva Tn, Yu. Ya. Vatazhok, Mittenberg Ag, Yu. B. Ermolaeva, Konstantinova Im, A. S. Tsimokha

Publikováno v: Cell and Tissue Biology. 1:334-342

In the present work, changes in the subunit composition, phosphorylation state, and enzymatic activities of 26S proteasomes undergoing programmed cell death were studied. Apoptosis in proerythroleukemic K562 cells was induced by the glutathione-deple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e7a4aa93f147bbcc21ca82ef2dc84e1
https://doi.org/10.1134/s1990519x07040050

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Regulation of the specificity of the 26S proteasome endoribonuclease activity in K562 cells under the action of differentiation and apoptosis inducers

Autor: Valentina A. Kulichkova, Moiseeva Tn, Konstantinova Im, I. V. Pugacheva, Mittenberg Ag, L. N. Gause, A. S. Tsimokha

Publikováno v: Cell and Tissue Biology. 1:162-168

The specificity of the 26S proteasome endoribonuclease activity in proerythroleukemic K562 cells has been shown to change under the effects of inducers of erythroid differentiation inducers led to specific stimulation of RNase activity for certain mR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::688de0b5060bf50d7ebaed574b8f30d7
https://doi.org/10.1134/s1990519x07020071

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U87 RNA, a novel C/D box small nucleolar RNA from mammalian cells

Autor: Dmitri A. Kramerov, L. N. Gause, Konstantinova Im, J. A. Makarova, Irina K. Gogolevskaya, Valentina A. Kulichkova

Publikováno v: Gene. 292:199-204

A novel 72 nt small nucleolar RNA (snoRNA) called U87 was found in rat liver cells. This RNA possesses the features of C/D box snoRNA family: boxes C, D 0 ,C 0 , D, and 11 nt antisense element complementary to 28S ribosomal RNA (rRNA). The vast major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed61225f4a8101e893571a7b40cd1342
https://doi.org/10.1016/s0378-1119(02)00678-9

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26S proteasome exhibits endoribonuclease activity controlled by extra-cellular stimuli

Autor: Moiseeva Tn, Olga A. Fedorova, Larissa Lezina, Valentina A. Kulichkova, Nickolai A. Barlev, Mittenberg Ag, Konstantinova Im, A. S. Tsimokha, Andrew Bottril, Larissa N Gauze

Publikováno v: Cell cycle (Georgetown, Tex.). 9(4)

26S proteasome is a large multi-subunit protein complex involved in proteolytic degradation of proteins. In addition to its canonical proteolytic activity, the proteasome is also associated with recently characterized endoribonuclease (endo- RNAse) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f59e814c314981cb791327745481e3
https://pubmed.ncbi.nlm.nih.gov/20237415

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Role of Proteasomes in Cellular Regulation

Autor: Mittenberg Ag, A. S. Tsimokha, Konstantinova Im

Publikováno v: International Review of Cell and Molecular Biology ISBN: 9780123743749

The 26S proteasome is the key enzyme of the ubiquitin-dependent pathway of protein degradation. This energy-dependent nanomachine is composed of a 20S catalytic core and associated regulatory complexes. The eukaryotic 20S proteasomes demonstrate besi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fc53763d7eb672c4ab4aedb338ddb34
https://doi.org/10.1016/s1937-6448(08)00602-3

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Changes in composition and activities of 26S proteasomes under the action of doxorubicin--apoptosis inductor of erythroleukemic K562 cells

Autor: Valentina A. Kulichkova, Mittenberg Ag, L. N. Gause, A. S. Tsimokha, I. V. Kozhukharova, Konstantinova Im

Publikováno v: Cell biology international. 31(4)

Changes in the subunit composition, phosphorylation of the subunits, and regulation of the activities of 26S proteasomes in proliferating cells undergoing programmed cell death have not been studied so far. Moreover, there are no reports on phosphory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d776202592760bb02e4c99f7d615d51
https://pubmed.ncbi.nlm.nih.gov/17346995

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