Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Konstantinos V Floros"'
Autor:
Konstantinos V. Floros, Ayesha T. Chawla, Mia O. Johnson-Berro, Rishabh Khatri, Angeliki M. Stamatouli, Sosipatros A. Boikos, Mikhail G. Dozmorov, L. Ashley Cowart, Anthony C. Faber
Publikováno v:
Cell Stress, Vol 6, Iss 2, Pp 21-29 (2022)
Ferroptosis is an iron-dependent, oxidative form of cell death that is countered mainly by glutathione peroxidase 4 (GPX4) and the production of glutathione (GSH), which is formed from cysteine. The identification of the cancers that may benefit from
Externí odkaz:
https://doaj.org/article/f618b350f3444237b6c25f6ff722b357
Autor:
Konstantinos V. Floros, Sheeba Jacob, Richard Kurupi, Carter K. Fairchild, Bin Hu, Madhavi Puchalapalli, Jennifer E. Koblinski, Mikhail G. Dozmorov, Sosipatros A. Boikos, Maurizio Scaltriti, Anthony C. Faber
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-13 (2021)
Abstract Human epidermal growth factor receptor 2 gene (HER2) is focally amplified in approximately 20% of breast cancers. HER2 inhibitors alone are not effective, and sensitizing agents will be necessary to move away from a reliance on heavily toxic
Externí odkaz:
https://doaj.org/article/38b772c2e3b047a0a0603783709c7fe0
Autor:
Anthony C. Faber, Cyril H. Benes, Mikhail G. Dozmorov, Devraj Basu, Iain M. Morgan, Yue Sun, Hisashi Harada, Jennifer E. Koblinski, Sosipatros A. Boikos, Maninderjit S. Ghotra, Krista M. Dalton, Patricia Greninger, Ellen Murchie, Regina K. Egan, Giovanna Stein Crowther, Rishabh Khatri, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Jinyang Cai, Ayesha T. Chawla, Sheeba Jacob, Konstantinos V. Floros, Richard Kurupi
Biological importance of Gab1 in HNSCC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1755ff52a1c2abd42395916bda423b
https://doi.org/10.1158/2767-9764.22545726.v1
https://doi.org/10.1158/2767-9764.22545726.v1
Autor:
Anthony C. Faber, Cyril H. Benes, Mikhail G. Dozmorov, Devraj Basu, Iain M. Morgan, Yue Sun, Hisashi Harada, Jennifer E. Koblinski, Sosipatros A. Boikos, Maninderjit S. Ghotra, Krista M. Dalton, Patricia Greninger, Ellen Murchie, Regina K. Egan, Giovanna Stein Crowther, Rishabh Khatri, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Jinyang Cai, Ayesha T. Chawla, Sheeba Jacob, Konstantinos V. Floros, Richard Kurupi
Preclinical and clinical studies have evidenced that effective targeted therapy treatment designed against receptor tyrosine kinases (RTKs) in different solid tumor paradigms is predicated on simultaneous inhibition of both the PI3K and MEK intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024b6b35f0eff8644abf41336ecc088a
https://doi.org/10.1158/2767-9764.c.6551016.v1
https://doi.org/10.1158/2767-9764.c.6551016.v1
Autor:
Anthony C. Faber, Cyril H. Benes, Mikhail G. Dozmorov, Devraj Basu, Iain M. Morgan, Yue Sun, Hisashi Harada, Jennifer E. Koblinski, Sosipatros A. Boikos, Maninderjit S. Ghotra, Krista M. Dalton, Patricia Greninger, Ellen Murchie, Regina K. Egan, Giovanna Stein Crowther, Rishabh Khatri, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Jinyang Cai, Ayesha T. Chawla, Sheeba Jacob, Konstantinos V. Floros, Richard Kurupi
Cell line information and SHP099 screen data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5661eba48fd98960c0399d013483bf
https://doi.org/10.1158/2767-9764.22545723
https://doi.org/10.1158/2767-9764.22545723
Autor:
Anthony C. Faber, Sosipatros A. Boikos, Jennifer E. Koblinski, John Glod, Mikhail G. Dozmorov, Janina P. Lewis, Kimberly Swift, Sivapriya Ramamoorthy, Madhavi Puchalapalli, Bin Hu, Benjamin R. Belvin, Krista M. Powell, Colin M. Coon, Mayuri Shende, Carter K. Fairchild, Richard Kurupi, Sheeba Jacob, JinYang Cai, Konstantinos V. Floros
MYCN is amplified in 20% to 25% of neuroblastoma, and MYCN-amplified neuroblastoma contributes to a large percent of pediatric cancer–related deaths. Therapy improvements for this subtype of cancer are a high priority. Here we uncover a MYCN-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96dc3c4929cc3bd64ce50fa635a4bb33
https://doi.org/10.1158/0008-5472.c.6513141.v1
https://doi.org/10.1158/0008-5472.c.6513141.v1
Autor:
Anthony C. Faber, Sosipatros A. Boikos, Jennifer E. Koblinski, John Glod, Mikhail G. Dozmorov, Janina P. Lewis, Kimberly Swift, Sivapriya Ramamoorthy, Madhavi Puchalapalli, Bin Hu, Benjamin R. Belvin, Krista M. Powell, Colin M. Coon, Mayuri Shende, Carter K. Fairchild, Richard Kurupi, Sheeba Jacob, JinYang Cai, Konstantinos V. Floros
Supplemental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f236c492c96fa96a155b8a75741d3e5
https://doi.org/10.1158/0008-5472.22428786.v1
https://doi.org/10.1158/0008-5472.22428786.v1
Autor:
Anthony C. Faber, Sosipatros A. Boikos, Jennifer E. Koblinski, John Glod, Mikhail G. Dozmorov, Janina P. Lewis, Kimberly Swift, Sivapriya Ramamoorthy, Madhavi Puchalapalli, Bin Hu, Benjamin R. Belvin, Krista M. Powell, Colin M. Coon, Mayuri Shende, Carter K. Fairchild, Richard Kurupi, Sheeba Jacob, JinYang Cai, Konstantinos V. Floros
Figure S5. Amplified MYCN sensitizes neuroblastomas to auranofin. Auranofin increases iron and glutathione levels and induces ROS-dependent ferroptotic cell death in MYCN-amplified NBs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0151f83e63d8fe36a1a9eca122e4746
https://doi.org/10.1158/0008-5472.22428798
https://doi.org/10.1158/0008-5472.22428798
Autor:
Anthony C. Faber, Jeffrey A. Engelman, Hiromichi Ebi, Bradley Bernstein, Lecia V. Sequist, Mikhail Dozmorov, Shirley M. Taylor, Sinem E. Sahingur, Zofia Piotrowska, Brad E. Windle, Tara J. Nulton, Maria Gomez-Caraballo, Hannah L. Archibald, Shawn Gillepsie, Angel Garcia, Elizabeth L. Lockerman, Neha U. Patel, Mark T. Hughes, Daniel A.R. Heisey, Yotam Drier, Hillary E. Mulvey, Haichuan Hu, Mark A. Hicks, Konstantinos V. Floros, Jungoh Ham, Hidenori Kitai, Aaron N. Hata, Timothy L. Lochmann, Matthew J. Niederst, Kyung-A Song
Top 10 correlated genes to BIM (BCL2L11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28634790899e5554faee70782d605662
https://doi.org/10.1158/1078-0432.22462244.v1
https://doi.org/10.1158/1078-0432.22462244.v1
Autor:
Anthony C. Faber, Cyril H. Benes, Hisashi Harada, Geoffrey W. Krystal, Andrew J. Souers, Joel D. Leverson, Sosipatros A. Boikos, Carlotta Costa, Scott J. Dylla, Laura R. Saunders, Yuki Kato Maves, Patricia Greninger, Giovanna T. Stein, Ryan J. March, Wade Cook, Krista M. Powell, Mitra Naseri, Konstantinos V. Floros, Timothy L. Lochmann
Supplemental Table 1 shows venetoclax screen data (AUC and IC50) across 791 solid tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974ca20df2e1802e3e681d692956cbf8
https://doi.org/10.1158/1078-0432.22466576.v1
https://doi.org/10.1158/1078-0432.22466576.v1