Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Konstantinos Stamatopoulos"'
Autor:
Farzaneh Salem, Dung Nguyen, Mark Bush, Katy P. Moore, Jennypher Mudunuru, Konstantinos Stamatopoulos, Nilay Thakkar, Kunal S. Taskar
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 11, Pp 1881-1892 (2024)
Abstract It is critical to understand the impact of significant physiological changes during pregnancy on the extent of maternal and fetal drug exposure. Fostemsavir (FTR) is a prodrug of temsavir (TMR) and is approved in combination with other antir
Externí odkaz:
https://doaj.org/article/1e240c9b9d424c11828e5c462b1db09a
Autor:
Erin Seonaid Campbell, Hannah Batchelor, James Matthew Butler, Ibrahim Khadra, Nena Minstry, Konstantinos Stamatopoulos
Publikováno v:
British Journal of Pharmacy, Vol 8, Iss 2 (2023)
The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiological
Externí odkaz:
https://doaj.org/article/be57fabfbb134e769c9825567320e12b
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2726 (2023)
A physiologically based biopharmaceutics model (PBBM) was developed to predict stool and urine sodium content in response to tenapanor administration in healthy subjects. Tenapanor is a minimally absorbed small molecule that inhibits the sodium/hydro
Externí odkaz:
https://doaj.org/article/34d0223a9f4942448ec74924e51af9a7
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde). This work studies the diss
Externí odkaz:
https://doaj.org/article/a28df2e36d804c7d9e1be05512fe9968
Autor:
Konstantinos Stamatopoulos, Connor O’Farrell, Mark J. H. Simmons, Hannah K. Batchelor, Nena Mistry
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 882 (2023)
A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus® 200 mg tablet) was developed and implemented to predict the pharmacokinetic (PK) data of healthy male volunteers by integrat
Externí odkaz:
https://doaj.org/article/971020ba2e1c4f99a5d83f9bf2223142
Autor:
Konstantinos Stamatopoulos, Paola Ferrini, Dung Nguyen, Ying Zhang, James M. Butler, Jon Hall, Nena Mistry
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 521 (2023)
A strategy followed to integrate in vitro solubility and permeability data into a PBBM model to predict the food effect of a BCS IV zwitterionic drug (GSK3640254) observed in clinical studies is described. The PBBM model was developed, qualified and
Externí odkaz:
https://doaj.org/article/39f48ef97de64c1ca49439a56fd7d6cb
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2193 (2022)
The in vitro release of theophylline from an extended-release dosage form was studied under different hydrodynamic conditions in a United States Pharmacopoeial (USP) dissolution system II and a bespoke in vitro tubular model of the human colon, the D
Externí odkaz:
https://doaj.org/article/81af068eed1445bfb1774a0549b819c5
Autor:
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos, Caroline L. Hoad, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor, Alessio Alexiadis
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1402 (2022)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/a147ba1016604bc4b9fe7911f6d82691
Autor:
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos, Caroline L. Hoad, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor, Alessio Alexiadis
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 184 (2022)
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic
Externí odkaz:
https://doaj.org/article/7613cdd0ba5543b0814e9a526b2a501f
Autor:
Connor O’Farrell, Caroline L. Hoad, Konstantinos Stamatopoulos, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1545 (2021)
Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us
Externí odkaz:
https://doaj.org/article/68d9ca066dec4482b4222dd190fd60e2