Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Konstantinos Paletas"'
Autor:
Thomas Karagiannis, Paschalis Paschos, David R. Matthews, Konstantinos Paletas, Apostolos Tsapas
OBJECTIVE: To assess the efficacy and safety of dipeptidyl peptidase-4 (DPP-4) inhibitors compared with metformin as monotherapy, or with other commonly used hypoglycaemic drugs combined with metformin, in adults with type 2 diabetes mellitus. DESIGN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d326e98ff6345c3e4de7d6568cf357
https://doi.org/10.1136/bmj.e1369
https://doi.org/10.1136/bmj.e1369
Autor:
Dimitrios Papazoglou, Konstantinos Paletas, Fanny Stutzmann, Marion Marchand, David Meyre, Vincent Vatin, Konstantinos Rouskas, Philippe Froguel, Anastasia Kouvatsi
Publikováno v:
Obesity. 20:2278-2282
Melanocortin-4 receptor (MC4R) loss-of-function mutations are the commonest genetic cause of human monogenic obesity, so far. The contribution of MC4R coding mutations to severe obesity in the high-obesity prone Greek population has not been investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55654d47ebf786789ac2df4961bf1de
https://doi.org/10.1038/oby.2012.77
https://doi.org/10.1038/oby.2012.77
Autor:
Konstantinos Paletas, Philippe Froguel, Jérôme Delplanque, Vincent Vatin, David Meyre, Yann Labrune, Konstantinos Rouskas, Emmanuelle Durand, Apostolos Tsapas, Anastasia Kouvatsi, Dimitrios Papazoglou, Stéphane Lobbens
Publikováno v:
Obesity. 20:389-395
Twenty-four single-nucleotide polymorphisms (SNPs) have been reproducibly associated with obesity. We performed a follow-up study for obesity in the Greek adult population. A total of 510 obese and 469 lean adults were genotyped for 24 SNPs. We teste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c8c4aac25fccb5448916e9b9de9806
https://doi.org/10.1038/oby.2011.177
https://doi.org/10.1038/oby.2011.177
Autor:
Vassilios G, Athyros, Emmanouel, Ganotakis, Genovefa D, Kolovou, Vassilios, Nicolaou, Apostolos, Achimastos, Eleni, Bilianou, Theodore, Alexandrides, Asterios, Karagiannis, Konstantinos, Paletas, Evangelos N, Liberopoulos, Konstantinos, Tziomalos, Dimitrios, Petridis, Anna, Kakafika, Moses S, Elisaf, Dimitri P, Mikhailidis, N, Tsakoudakis
Publikováno v:
Current Vascular Pharmacology. 9:647-657
AIM: To assess the reduction in estimated cardiovascular disease (e-CVD) risk after multifactorial treatment for 6 months and follow this change during the next 3-years. PATIENTS-METHODS: This prospective, randomized, target driven study included 1,1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886d66cda30aa2c0ff01df268244bfd9
https://doi.org/10.2174/157016111797484080
https://doi.org/10.2174/157016111797484080
Autor:
Paschalis Paschos, Dimitrios Papazoglou, Konstantinos Papatheodorou, Efstratios Maltezos, Konstantinos Paletas, Apostolos Tsapas, Nikolaos Papanas
Publikováno v:
Diabetes Care
OBJECTIVE To estimate the accuracy of Neuropad for the diagnosis and staging of distal symmetric polyneuropathy (DPN) across different stages of neuropathy, using multiple-level likelihood ratios (LRs) to interpret the time necessary to complete the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e64504a44df133da7740239cf37c15e
https://doi.org/10.2337/dc10-2205
https://doi.org/10.2337/dc10-2205
Publikováno v:
Cell Adhesion & Migration. 5:258-265
In the present study the effect of high glucose concentrations, insulin, PPARγ activators (rosiglitazone) and NHE-1 inhibitors (cariporide) in atherosclerosis-related functions of human monocytes was investigated. Monocyte adhesion to laminin-1, col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa110eae635dbd79659f1563174a402b
https://doi.org/10.4161/cam.5.3.14534
https://doi.org/10.4161/cam.5.3.14534
Autor:
Martha Kaloyianni, Apostolos Tsapas, Konstantinos Paletas, Maria Sarigianni, Dimitri P. Mikhailidis, George Koliakos, Larry Fliegel
Publikováno v:
Expert Opinion on Investigational Drugs. 19:1545-1556
Importance of the field: The sodium/hydrogen exchanger-1 (NHE-1/SLC9A1) is a ubiquitous plasma membrane protein whose main role is maintenance of intracellular pH and volume. NHE-1 plays a role in atherogenesis; however, its clinical relevance has no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9a017c5932890c98b296b0cefd6acc
https://doi.org/10.1517/13543784.2010.532123
https://doi.org/10.1517/13543784.2010.532123
Autor:
Konstantinos Paletas, Martha Kaloyianni, Dimitri P. Mikhailidis, Maria Sarigianni, Apostolos Tsapas, George Koliakos
Publikováno v:
The Open Cardiovascular Medicine Journal
Background: Sodium/hydrogen exchanger-1 (NHE-1) contributes to maintaining intracellular pH (pHi). We assessed the effect of glucose, insulin, leptin and adrenaline on NHE-1 activity in human monocytes in vitro. These cells play a role in atherogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b31ae163cde26453d54f66378ebcf4c
https://doi.org/10.2174/1874192401004010181
https://doi.org/10.2174/1874192401004010181
Autor:
Diamantis G. Konstantinidis, Konstantinos Paletas, Eleni Bekiari, George Koliakos, Martha Kaloyianni, Maria Sarigianni, Apostolos Tsapas
Publikováno v:
Angiology. 62:38-45
We assessed the effect of epinephrine on human monocytes. Monocytes were isolated from 16 healthy obese and 10 lean healthy subjects. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. Obese subjects were subdivided into 2 sub-gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40d901e1797af262ffe4c00885131b78
https://doi.org/10.1177/0003319710371616
https://doi.org/10.1177/0003319710371616
Publikováno v:
Cell Stress and Chaperones. 14:591-601
Leptin, a 16-kDa cytokine produced mainly by the adipose tissue, is known to increase energy expenditure while at the same time lowering food intake by acting directly on the hypothalamus. ObRb, the leptin receptor mostly involved in intracellular si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d2abb34e89246baa93435c1465138d
https://doi.org/10.1007/s12192-009-0110-4
https://doi.org/10.1007/s12192-009-0110-4