Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Konstantinos Meletis"'
Autor:
Yuvarani Masarapu, Egle Cekanaviciute, Zaneta Andrusivova, Jakub O. Westholm, Åsa Björklund, Robin Fallegger, Pau Badia-i-Mompel, Valery Boyko, Shubha Vasisht, Amanda Saravia-Butler, Samrawit Gebre, Enikő Lázár, Marta Graziano, Solène Frapard, Robert G. Hinshaw, Olaf Bergmann, Deanne M. Taylor, Douglas C. Wallace, Christer Sylvén, Konstantinos Meletis, Julio Saez-Rodriguez, Jonathan M. Galazka, Sylvain V. Costes, Stefania Giacomello
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and c
Externí odkaz:
https://doaj.org/article/e005e5c2fdd54d54a58a469fc7aa1cbf
Autor:
Hans Brünner, Hoseok Kim, Sofie Ährlund-Richter, Josina Anna van Lunteren, Ana Paula Crestani, Konstantinos Meletis, Marie Carlén
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109743- (2024)
Summary: The ability to represent one’s own position in relation to cues, goals, or threats is crucial to successful goal-directed behavior. Using optotagging in knock-in rats expressing Cre recombinase in parvalbumin (PV) neurons (PV-Cre rats), we
Externí odkaz:
https://doaj.org/article/7fa73a8c4cbd43e89e8f2cb1aabe752c
Autor:
Haohao Wu, Charles Petitpré, Paula Fontanet, Anil Sharma, Carmelo Bellardita, Rolen M. Quadros, Paulo R. Jannig, Yiqiao Wang, J. Alexander Heimel, Kylie K. Y. Cheung, Simone Wanderoy, Yang Xuan, Konstantinos Meletis, Jorge Ruas, Channabasavaiah B. Gurumurthy, Ole Kiehn, Saida Hadjab, François Lallemend
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Molecular diversity of proprioceptive neuron types (Ia, Ib and II PNs) is unclear. Here, the authors characterized the functional organization and development of eight subtypes of PNs in mice. Importantly, Ia subtypes are plastic, suggesting a role i
Externí odkaz:
https://doaj.org/article/bf14515821cc4d14bb384469db2ce5f5
Autor:
Moritz Weglage, Emil Wärnberg, Iakovos Lazaridis, Daniela Calvigioni, Ourania Tzortzi, Konstantinos Meletis
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109437- (2021)
Summary: The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-spec
Externí odkaz:
https://doaj.org/article/37c33d2b8397455e9c5b6e4f143fbe61
Autor:
Shaina Lu, Cantin Ortiz, Daniel Fürth, Stephan Fischer, Konstantinos Meletis, Anthony Zador, Jesse Gillis
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001341 (2021)
High-throughput, spatially resolved gene expression techniques are poised to be transformative across biology by overcoming a central limitation in single-cell biology: the lack of information on relationships that organize the cells into the functio
Externí odkaz:
https://doaj.org/article/647bfa0ef7344221b9f7d06814d96bc6
Autor:
Antje Märtin, Daniela Calvigioni, Ourania Tzortzi, Janos Fuzik, Emil Wärnberg, Konstantinos Meletis
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4320-4333.e5 (2019)
Summary: The striatum is organized into two major outputs formed by striatal projection neuron (SPN) subtypes with distinct molecular identities. In addition, histochemical division into patch and matrix compartments represents an additional spatial
Externí odkaz:
https://doaj.org/article/6d6e0dd3dd8548ef8cffd557f57b3606
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83879 (2014)
The underlying circuit imbalance in major depression remains unknown and current therapies remain inadequate for a large group of patients. Discovery of the rapid antidepressant effects of ketamine--an NMDA receptor (NMDAR) antagonist--has linked the
Externí odkaz:
https://doaj.org/article/91e29715fbfb458c85e4b3c44a6419c7
Autor:
Konstantinos Meletis, Fanie Barnabé-Heider, Marie Carlén, Emma Evergren, Nikolay Tomilin, Oleg Shupliakov, Jonas Frisén
Publikováno v:
PLoS Biology, Vol 6, Iss 7, p e182 (2008)
Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells th
Externí odkaz:
https://doaj.org/article/12e0b66476344eed8c722adf3eb1708d
Autor:
Koós T, Peter J. Magill, Daniela Calvigioni, Natalie M. Doig, Konstantinos Meletis, Krishnakanth Kondabolu, Ayeko O, Torres A, Bakhtawer Khan
The striatum and subthalamic nucleus (STN) are considered to be the primary input nuclei of the basal ganglia. Projection neurons of both striatum and STN can extensively interact with other basal ganglia nuclei, and there is growing anatomical evide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45061522a5848162a9522c317fc8f8e4
https://ora.ox.ac.uk/objects/uuid:44bf4707-cabc-465b-89ae-561289ef8b25
https://ora.ox.ac.uk/objects/uuid:44bf4707-cabc-465b-89ae-561289ef8b25
Autor:
Daniela Calvigioni, Janos Fuzik, Pierre Le Merre, Marina Slashcheva, Felix Jung, Cantin Ortiz, Antonio Lentini, Veronika Csillag, Marta Graziano, Ifigeneia Nikolakopoulou, Moritz Weglage, Iakovos Lazaridis, Hoseok Kim, Irene Lenzi, Hyunsoo Park, Björn Reinius, Marie Carlén, Konstantinos Meletis
Excitatory projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb) drive aversive responses. We used Patch-seq guided multimodal classification to define the structural and functional heterogeneity of the LHA-LHb pathway. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16819a2d087c6233d7c01651164ec75b
https://doi.org/10.1101/2022.11.17.516965
https://doi.org/10.1101/2022.11.17.516965