Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Konstantinos Koussis"'
Autor:
Konstantinos Koussis, Silvia Haase, Chrislaine Withers-Martinez, Helen R Flynn, Simone Kunzelmann, Evangelos Christodoulou, Fairouz Ibrahim, Mark Skehel, David A Baker, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012360 (2024)
The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically rele
Externí odkaz:
https://doaj.org/article/b62bcb1860a84ec8b769e6b711c15964
Autor:
Abhinay Ramaprasad, Paul-Christian Burda, Konstantinos Koussis, James A Thomas, Emma Pietsch, Enrica Calvani, Steven A Howell, James I MacRae, Ambrosius P Snijders, Tim-Wolf Gilberger, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011449 (2023)
Malaria parasite release (egress) from host red blood cells involves parasite-mediated membrane poration and rupture, thought to involve membrane-lytic effector molecules such as perforin-like proteins and/or phospholipases. With the aim of identifyi
Externí odkaz:
https://doaj.org/article/729265df578440d2850076d88548b0c4
Autor:
Konstantinos Koussis, Evi Goulielmaki, Anna Chalari, Chrislaine Withers-Martinez, Inga Siden-Kiamos, Kai Matuschewski, Thanasis G Loukeris
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170260 (2017)
Site-2 proteases (S2P) belong to the M50 family of metalloproteases, which typically perform essential roles by mediating activation of membrane-bound transcription factors through regulated intramembrane proteolysis (RIP). Protease-dependent liberat
Externí odkaz:
https://doaj.org/article/1286f99e77064fc3bc23e28991c1b711
Autor:
Zoi Tampaki, Ramadhan S Mwakubambanya, Evi Goulielmaki, Sofia Kaforou, Kami Kim, Andrew P Waters, Vern B Carruthers, Inga Siden-Kiamos, Thanasis G Loukeris, Konstantinos Koussis
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121379 (2015)
Regulated proteolysis is known to control a variety of vital processes in apicomplexan parasites including invasion and egress of host cells. Serine proteases have been proposed as targets for drug development based upon inhibitor studies that show p
Externí odkaz:
https://doaj.org/article/603d890f55bf4ceda2d032d4289d3cc5
Autor:
Elina Lidumniece, Michael J. Blackman, Konstantinos Koussis, Christine R. Collins, Aigars Jirgensons, Chrislaine Withers-Martinez, Abigail J. Perrin, Claudine Bisson, Fiona Hackett
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Malaria remains a major global health threat. In the face of increasing resistance to available chemotherapeutics, new antimalarial drugs with new modes of action are urgently needed. The causative agent of malaria is a single-celled par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379ef230c9ed98c0bd97da07cdfb48d8
https://doi.org/10.1073/pnas.2022696118
https://doi.org/10.1073/pnas.2022696118
Autor:
Min Shen, Steven Howell, Konstantinos Koussis, Ellen Knuepfer, Chrislaine Withers-Martinez, Ambrosius P. Snijders, Michael J. Blackman, James Thomas, Fiona Hackett, Matthew D. Hall, Michele S. Y. Tan
Publikováno v:
The EMBO Journal
Malaria parasite egress from host erythrocytes (RBCs) is regulated by discharge of a parasite serine protease called SUB1 into the parasitophorous vacuole (PV). There, SUB1 activates a PV‐resident cysteine protease called SERA6, enabling host RBC r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d83f537b19cbaae18e3936857730ccd
http://europepmc.org/articles/PMC8167364
http://europepmc.org/articles/PMC8167364
Autor:
Alexandre Hainard, Ambrosius P. Snijders, Michael J. Blackman, David Baker, Laura Peces-Barba Castaño, Abigail J. Perrin, Helen R. Flynn, Olalla Sanz, Patrizia Arboit, Aurélia C. Balestra, Natacha Klages, Konstantinos Koussis, Lorenzo Brusini, Marcus Bantscheff, Steven Howell, Sonja Ghidelli-Disse, Carla Pasquarello, Chrislaine Withers-Martinez, Mathieu Brochet
In malaria parasites, all cGMP-dependent signalling is mediated through a single cGMP-dependent protein kinase (PKG), a major function of which is to control essential calcium signals. However, how PKG transmits these signals in the absence of known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9eb84c45d763d5c07890cb224472b31
https://doi.org/10.1101/2020.07.18.209973
https://doi.org/10.1101/2020.07.18.209973
Autor:
Martine Bourquin, Taiwo Sam Awolola, Paolo Pelosi, Thomas Kröber, Francesca Romana Dani, Panagiota Tsitoura, Maria Konstantopoulou, Konstantinos Koussis, Patrick M. Guerin, Huili Qiao, Kostas Iatrou
Publikováno v:
Insect Biochemistry and Molecular Biology. 96:36-50
There is increasing interest in the development of effective mosquito repellents of natural origin to reduce transmission of diseases such as malaria and yellow fever. To achieve this we have employed an in vitro competition assay involving odorant-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aace0dfcc13e9d2642bc99f7c74df53e
https://doi.org/10.1016/j.ibmb.2018.03.008
https://doi.org/10.1016/j.ibmb.2018.03.008
Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function
Publikováno v:
Life Science Alliance
This work combines the use of an inducible Cre recombinase and different lox sites to simultaneously create multiple allelic replacements. We show that an essential malarial cGMP-dependent protein kinase functions exclusively during the release of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208b9703bc4db79ace0fb3921895daf1
https://doi.org/10.26508/lsa.201900626
https://doi.org/10.26508/lsa.201900626
Autor:
Trias Thireou, Katerina E. Tsitsanou, Konstantinos Koussis, Kostas Iatrou, Julie Kinnersley, Georgia Kythreoti, Thomas Kröber, Jing-Jiang Zhou, Christina E. Drakou, Elias Eliopoulos, Patrick M. Guerin, Spyros E. Zographos
Publikováno v:
Insect biochemistry and molecular biology. 98
In this work we report a fast and efficient virtual screening protocol for discovery of novel bioinspired synthetic mosquito repellents with lower volatility and, in all likelihood, increased protection time as compared with their plant-derived paren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baee34831a94a10d357c0f8b4b3f0207
https://pubmed.ncbi.nlm.nih.gov/29751047
https://pubmed.ncbi.nlm.nih.gov/29751047