Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Konstantinos Karakostis"'
Autor:
Konstantinos Karakostis, Monikaben Padariya, Aikaterini Thermou, Robin Fåhraeus, Umesh Kalathiya, Fritz Vollrath
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-5 (2024)
Abstract As species adapt to climatic changes, temperature-dependent functions of p53 in development, metabolism and cancer will adapt as well. Structural analyses of p53 epitopes interacting in response to environmental stressors, such as heat, may
Externí odkaz:
https://doaj.org/article/b608bb5feae546728508f828f44b25cc
Autor:
Konstantinos Karakostis, Laurence Malbert-Colas, Aikaterini Thermou, Borek Vojtesek, Robin Fåhraeus
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background The ATM kinase constitutes a master regulatory hub of DNA damage and activates the p53 response pathway by phosphorylating the MDM2 protein, which develops an affinity for the p53 mRNA secondary structure. Disruption of this inter
Externí odkaz:
https://doaj.org/article/6c35679e66534f3596b761aa7d227558
Autor:
Antonis Tsintarakis, Chara Papalouka, Christina Kontarini, Panagiotis Zoumpourlis, Konstantinos Karakostis, Maria Adamaki, Vassilis Zoumpourlis
Publikováno v:
Life, Vol 13, Iss 6, p 1361 (2023)
Complex signaling interactions between cancer cells and their microenvironments drive the clonal selection of cancer cells. Opposing forces of antitumor and tumorigenic potential regulate the survival of the fittest clones, while key genetic and epig
Externí odkaz:
https://doaj.org/article/0678162ce1694e7e8a8dda42baafc176
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-16 (2019)
Abstract Structured RNA regulatory motifs exist from the prebiotic stages of the RNA world to the more complex eukaryotic systems. In cases where a functional RNA structure is within the coding sequence a selective pressure drives a parallel co-evolu
Externí odkaz:
https://doaj.org/article/940722d8d55f44d7ae7b949183c2c420
Autor:
Konstantinos Karakostis, Ignacio López, Ana M. Peña-Balderas, Robin Fåhareus, Vanesa Olivares-Illana
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 36 (2020)
The p53 and Mouse double minute 2 (MDM2) proteins are hubs in extensive networks of interactions with multiple partners and functions. Intrinsically disordered regions help to adopt function-specific structural conformations in response to ligand bin
Externí odkaz:
https://doaj.org/article/1efa4182b74a4a719e9dedf2aae08ed5
Autor:
Alice J L Zheng, Aikaterini Thermou, Chrysoula Daskalogianni, Laurence Malbert-Colas, Konstantinos Karakostis, Ronan Le Sénéchal, Van Trang Dinh, Maria C Tovar Fernandez, Sébastien Apcher, Sa Chen, Marc Blondel, Robin Fahraeus
Publikováno v:
Nucleic acids research. 50(17)
Protein aggregates and abnormal proteins are toxic and associated with neurodegenerative diseases. There are several mechanisms to help cells get rid of aggregates but little is known on how cells prevent aggregate-prone proteins from being synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bcc2219015c138e4ae9ca394ff81454
https://pubmed.ncbi.nlm.nih.gov/36107769
https://pubmed.ncbi.nlm.nih.gov/36107769
Autor:
Monikaben Padariya, Mia-Lyn Jooste, Ted Hupp, Robin Fåhraeus, Borek Vojtesek, Fritz Vollrath, Umesh Kalathiya, Konstantinos Karakostis
The p53 tumor suppressor is a transcription factor with roles in cell development, apoptosis, oncogenesis, aging, and homeostasis in response to stresses and infections. p53 is tightly regulated by the MDM2 E3 ubiquitin ligase. The p53–MDM2 pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db0f478154f3475ac9270e943e069b8
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198296
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198296
Autor:
Christoforos Papademetriou, George Lazopoulos, Nikolaos Drakoulis, Vasileios Siokas, Michail Vikelis, Maria Papasavva, Konstantinos Karakostis, Emmanouil V. Dermitzakis, Efthimios Dardiotis, Martha-Spyridoula Katsarou
Publikováno v:
Journal of molecular neuroscience : MN. 72(2)
Cluster headache (CH) is a primary headache disorder with a complex genetic background. Several studies indicate a potential link between iron homeostasis and the pathophysiology of primary headaches. The HFE gene encodes for a protein involved in ir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255112b7789614c051561da9958b7803
https://pubmed.ncbi.nlm.nih.gov/34570359
https://pubmed.ncbi.nlm.nih.gov/34570359
Autor:
Konstantinos Karakostis, Ted R. Hupp, Friz Vollrath, Norman Salomao, Robin Fåhraeus, Borivoj Vojtesek
Few proteins are more studied than the p53 tumour suppressor, but what have we learned from these studies and what do we really know about p53 that can benefit clinical practice? The DNA sequence encoding p53 is frequently mutated in cancers but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250d7a0bff38326123fe3a8abe525681
https://ora.ox.ac.uk/objects/uuid:17a8176a-a959-4718-8524-0c01223f24b2
https://ora.ox.ac.uk/objects/uuid:17a8176a-a959-4718-8524-0c01223f24b2
Autor:
Ana M Peña-Balderas, Ignacio López, Vanesa Olivares-Illana, Robin Fåhareus, Konstantinos Karakostis
Publikováno v:
Biomolecules
COLIBRI
Universidad de la República
instacron:Universidad de la República
Biomolecules, Vol 11, Iss 36, p 36 (2021)
COLIBRI
Universidad de la República
instacron:Universidad de la República
Biomolecules, Vol 11, Iss 36, p 36 (2021)
The p53 and Mouse double minute 2 (MDM2) proteins are hubs in extensive networks of interactions with multiple partners and functions. Intrinsically disordered regions help to adopt function-specific structural conformations in response to ligand bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e23b210e4fcc1a369f07413b95d3c7
https://pubmed.ncbi.nlm.nih.gov/33396576
https://pubmed.ncbi.nlm.nih.gov/33396576