Ole-Oxy, a Semi-Synthetic Analog of Oleuropein, Ameliorates Acute Skin and Colon Inflammation in Mice

Autor: Nikolaos V. Angelis, Efthymios Paronis, Georgia Sarikaki, Antonios Kyriakopoulos, Anna Agapaki, Pigi-Maria Niotopoulou, Christina C. Knai, Pavlos Alexakos, Odyssefs Liagkas, Konstantinos F. Mavreas, Constantin N. Baxevanis, Alexios-Leandros Skaltsounis, Ourania E. Tsitsilonis, Ioannis K. Kostakis

Publikováno v: Antioxidants, Vol 13, Iss 11, p 1422 (2024)

Inflammation is a key process in the pathophysiology of various diseases, with macrophages playing a central role in the inflammatory response. This study investigates the anti-inflammatory potential of a newly synthesized analog of oleuropein (OP),

Externí odkaz: https://doaj.org/article/19768f9ad8b743d68624dd471286ba8f

A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function

Autor: Michail-Panagiotis Minadakis, Konstantinos F. Mavreas, Dionysios D. Neofytos, Maria Paschou, Artemis Kogkaki, Varvara Athanasiou, Michael Mamais, Daniele Veclani, Hermis Iatrou, Alessandro Venturini, Evangelia D. Chrysina, Panagiota Papazafiri, Thanasis Gimisis

Publikováno v: Organic & Biomolecular Chemistry. 20:2407-2423

Synthesis and study of RotA, an inhibitor of glycogen phosphorylase (GP), which when bound at the active site of GP, produces a strong fluorescence signal, allowing utilization of RotA as a probe that brings GP “to light” in the cellular milieu.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb6d3387362430a18fe7b96805e67b1
https://doi.org/10.1039/d1ob02211c

Synthesis, Kinetic and Conformational Studies of 2-Substituted-5-(β-d-glucopyranosyl)-pyrimidin-4-ones as Potential Inhibitors of Glycogen Phosphorylase

Autor: Evangelia D. Chrysina, Alessandro Venturini, Dionysios D. Neofytos, Thanasis Gimisis, Konstantinos F. Mavreas

Publikováno v: Molecules, Vol 25, Iss 5463, p 5463 (2020)
Molecules
Volume 25
Issue 22

Dysregulation of glycogen phosphorylase, an enzyme involved in glucose homeostasis, may lead to a number of pathological states such as type 2 diabetes and cancer, making it an important molecular target for the development of new forms of pharmaceut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0256ca9e85d7e62aa4947c752ae2a16f
https://www.mdpi.com/1420-3049/25/22/5463

Multiscale time-resolved fluorescence study of a glycogen phosphorylase inhibitor combined with quantum chemistry calculations

Autor: Dimitra Markovitsi, Konstantinos F. Mavreas, Michael Mamais, Thanasis Gimisis, Filippo Monti, Evangelia D. Chrysina, Alessandro Venturini, Thomas Gustavsson, Valentin Maffeis

Publikováno v: Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics, 2019, 21 (14), pp.7685-7696. ⟨10.1039/C8CP07538G⟩
Physical chemistry chemical physics (Online) 21 (2019): 7685–7696. doi:10.1039/C8CP07538G
info:cnr-pdr/source/autori:Valentin Maffeis, Konstantinos Mavreas, Filippo Monti, Michael Mamais, Thomas Gustavsson, Evangelia D. Chrysina, Dimitra Markovitsi, Thanasis Gimisis and Alessandro Venturini/titolo:Multiscale time-resolved fluorescence study of a glycogen phosphorylase inhibitor combined with quantum chemistry calculations/doi:10.1039%2FC8CP07538G/rivista:Physical chemistry chemical physics (Online)/anno:2019/pagina_da:7685/pagina_a:7696/intervallo_pagine:7685–7696/volume:21
Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2019, 21 (14), pp.7685-7696. ⟨10.1039/C8CP07538G⟩

International audience; A fluorescence study of N1-(β-D-glucopyranosyl)-N4-[2-acridin-9(10H)-onyl]-cytosine (GLAC), the first fluorescent potent inhibitor of glycogen phosphorylase (GP), in neutral aqueous solution, is presented herein. Quantum chem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9a8ddaeb25052ea644fe1c2a6f2e8e
https://pubmed.ncbi.nlm.nih.gov/30912774