Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Konstantinos Drosopoulos"'
Autor:
Nirmesh Patel, Daniel Weekes, Konstantinos Drosopoulos, Patrycja Gazinska, Elodie Noel, Mamun Rashid, Hasan Mirza, Jelmar Quist, Fara Brasó-Maristany, Sumi Mathew, Riccardo Ferro, Ana Mendes Pereira, Cynthia Prince, Farzana Noor, Erika Francesch-Domenech, Rebecca Marlow, Emanuele de Rinaldis, Anita Grigoriadis, Spiros Linardopoulos, Pierfrancesco Marra, Andrew N. J. Tutt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions a
Externí odkaz:
https://doaj.org/article/5040e6ddb1d140d09e37fbc06a8ca400
Autor:
François Saint-Dizier, Thomas P. Matthews, Aaron M. Gregson, Hugues Prevet, Tatiana McHardy, Giampiero Colombano, Harry Saville, Martin Rowlands, Caroline Ewens, P. Craig McAndrew, Kathy Tomlin, Delphine Guillotin, Grace Wing-Yan Mak, Konstantinos Drosopoulos, Ioannis Poursaitidis, Rosemary Burke, Rob van Montfort, Spiros Linardopoulos, Ian Collins
Publikováno v:
Journal of Medicinal Chemistry. 66:2622-2645
Autor:
Spiros Linardopoulos, Suzanne A. Eccles, Swen Hoelder, Julian Blagg, Florence I. Raynaud, Rob L.M. van Montfort, Rosemary Burke, Harry Saville, Simone Filosto, Efthymia Theofani, Angela Hayes, Sébastien Naud, Isaac M. Westwood, Paolo Innocenti, Hannah L. Woodward, Katie Walsh, Konstantinos Drosopoulos, Amir Faisal, Mark D. Gurden, Grace Wing-Yan Mak, Simon J. Anderhub
Chromosome alignment errors, time course and synergy volume in cells treated with BOS172722 and Paclitaxel.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106e0fefff76c3cd8a64fe3f8f0ad4a7
https://doi.org/10.1158/1535-7163.22505688.v1
https://doi.org/10.1158/1535-7163.22505688.v1
Autor:
Spiros Linardopoulos, Suzanne A. Eccles, Swen Hoelder, Julian Blagg, Florence I. Raynaud, Rob L.M. van Montfort, Rosemary Burke, Harry Saville, Simone Filosto, Efthymia Theofani, Angela Hayes, Sébastien Naud, Isaac M. Westwood, Paolo Innocenti, Hannah L. Woodward, Katie Walsh, Konstantinos Drosopoulos, Amir Faisal, Mark D. Gurden, Grace Wing-Yan Mak, Simon J. Anderhub
Horizon PTEN +/- cell line panel and Enrichment of mutated genes in cell lines sensitive to BOS172722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f0d2b00e9ee702d95e4330a23c6d43
https://doi.org/10.1158/1535-7163.22505685.v1
https://doi.org/10.1158/1535-7163.22505685.v1
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1953
Cellular models for siRNA and small molecule high throughput screening have been widely used in the last decade to identify targets for drug discovery. As an example, we present a two-fold readout approach based on cell viability and multipolar pheno
Autor:
Simon J, Anderhub, Grace Wing-Yan, Mak, Mark D, Gurden, Amir, Faisal, Konstantinos, Drosopoulos, Katie, Walsh, Hannah L, Woodward, Paolo, Innocenti, Isaac M, Westwood, Sébastien, Naud, Angela, Hayes, Efthymia, Theofani, Simone, Filosto, Harry, Saville, Rosemary, Burke, Rob L M, van Montfort, Florence I, Raynaud, Julian, Blagg, Swen, Hoelder, Suzanne A, Eccles, Spiros, Linardopoulos
Publikováno v:
Molecular cancer therapeutics. 18(10)
BOS172722 (CCT289346) is a highly potent, selective, and orally bioavailable inhibitor of spindle assembly checkpoint kinase MPS1. BOS172722 treatment alone induces significant sensitization to death, particularly in highly proliferative triple-negat
Autor:
Nirmesh, Patel, Daniel, Weekes, Konstantinos, Drosopoulos, Patrycja, Gazinska, Elodie, Noel, Mamun, Rashid, Hasan, Mirza, Jelmar, Quist, Fara, Brasó-Maristany, Sumi, Mathew, Riccardo, Ferro, Ana Mendes, Pereira, Cynthia, Prince, Farzana, Noor, Erika, Francesch-Domenech, Rebecca, Marlow, Emanuele, de Rinaldis, Anita, Grigoriadis, Spiros, Linardopoulos, Pierfrancesco, Marra, Andrew N J, Tutt
Publikováno v:
Patel, N, Weekes, D, Drosopoulos, K, Gazinska, P, Noel, E, Rashid, M, Mirza, H, Quist, J, Brasó-Maristany, F, Mathew, S, Ferro, R, Pereira, A M, Prince, C, Noor, F, Francesch-Domenech, E, Marlow, R, de Rinaldis, E, Grigoriadis, A, Linardopoulos, S, Marra, P & Tutt, A N J 2018, ' Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer ', Nature Communications, vol. 9, no. 1, 1044 . https://doi.org/10.1038/s41467-018-03283-z
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Triple negative breast cancers (TNBCs) lack recurrent targetable driver mutations but demonstrate frequent copy number aberrations (CNAs). Here, we describe an integrative genomic and RNAi-based approach that identifies and validates gene addictions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::364282ebfd9cfb5866f824e8e053da52
https://kclpure.kcl.ac.uk/ws/files/111402468/Integrated_genomics_and_functional_PATEL_Accepted_1_February_2018_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/111402468/Integrated_genomics_and_functional_PATEL_Accepted_1_February_2018_GOLD_VoR_CC_BY_.pdf
Autor:
Saoirse O, Dolly, Mark D, Gurden, Konstantinos, Drosopoulos, Paul, Clarke, Johann, de Bono, Stan, Kaye, Paul, Workman, Spiros, Linardopoulos
Publikováno v:
British Journal of Cancer
Background: F-box and WD40 repeat domain-containing 7 (FBXW7) is an E3 ubiquitin ligase involved in the ubiquitination and degradation of multiple oncogenic substrates. The tumour suppressor function is frequently lost in multiple cancers through gen
Publikováno v:
Expert Opinion On Therapeutic Targets 11:5(May2007):641-659
Recent complicated advances towards the blueprinting of the altered molecular networks that lie behind cancer development have paved the way for targeted therapy in cancer. This directed a significant part of the research community to the development
Publikováno v:
Nature communications. 5
Centrosome amplification has been extensively associated with cancer. Cancer cells with extra centrosomes have the ability to cluster the extra centrosomes and divide in a bipolar fashion. Although a number of proteins have been shown to be involved