Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Konstantinos Charizanis"'
Autor:
Jay Pepose, Mitchell Brigell, Eliot Lazar, Curtis Heisel, Jonah Yousif, Kavon Rahmani, Ajay Kolli, Min Hwang, Cara Mitrano, Audrey Lazar, Konstantinos Charizanis, Mina Sooch, Marguerite McDonald
Publikováno v:
BMC Ophthalmology, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Purpose Dim light vision disturbances (DLD) comprise a wide range of symptoms affecting the quality of vision at low illumination including glare, halos, and starbursts. This exploratory study investigated 1.0% phentolamine mesylate ophthalm
Externí odkaz:
https://doaj.org/article/ae48f09373974398b5963ac579059bf2
Autor:
Marianne Goodwin, Apoorva Mohan, Ranjan Batra, Kuang-Yung Lee, Konstantinos Charizanis, Francisco José Fernández Gómez, Sabiha Eddarkaoui, Nicolas Sergeant, Luc Buée, Takashi Kimura, H. Brent Clark, Joline Dalton, Kenji Takamura, Sebastien M. Weyn-Vanhentenryck, Chaolin Zhang, Tammy Reid, Laura P.W. Ranum, John W. Day, Maurice S. Swanson
Publikováno v:
Cell Reports, Vol 12, Iss 7, Pp 1159-1168 (2015)
For some neurological disorders, disease is primarily RNA mediated due to expression of non-coding microsatellite expansion RNAs (RNAexp). Toxicity is thought to result from enhanced binding of proteins to these expansions and depletion from their no
Externí odkaz:
https://doaj.org/article/c1f149d4c87f43cf89365b6092f6e218
Autor:
Kuang‐Yung Lee, Moyi Li, Mini Manchanda, Ranjan Batra, Konstantinos Charizanis, Apoorva Mohan, Sonisha A. Warren, Christopher M. Chamberlain, Dustin Finn, Hannah Hong, Hassan Ashraf, Hideko Kasahara, Laura P. W. Ranum, Maurice S. Swanson
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 12, Pp 1887-1900 (2013)
Abstract Myotonic dystrophy (DM) is a multi‐systemic disease that impacts cardiac and skeletal muscle as well as the central nervous system (CNS). DM is unusual because it is an RNA‐mediated disorder due to the expression of toxic microsatellite
Externí odkaz:
https://doaj.org/article/e6ecfc7eb11f40d5b72afc0761cf559b
Autor:
Charles B. Slonim, Mina Sooch, Paul M. Karpecki, Eliot Lazar, Seth A Klapman, Robert Smyth-Medina, Alan R. Meyer, Jonah E Yousif, Harvey B DuBiner, Reda M Jaber, Paul J Hartman, Arin T Amin, Sayoko E Moroi, Marc A. Abrams, Jay S. Pepose, Marguerite B. McDonald, Konstantinos Charizanis
Publikováno v:
Clinical Ophthalmology (Auckland, N.Z.)
Jay S Pepose,1,2 Paul J Hartman,3 Harvey B DuBiner,4 Marc A Abrams,5 Robert J Smyth-Medina,6 Sayoko E Moroi,7 Alan R Meyer,8 Mina P Sooch,8 Reda M Jaber,8 Konstantinos Charizanis,8 Seth A Klapman,8 Arin T Amin,8 Jonah E Yousif,8 Eliot S Lazar,9 Paul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a4dbe20ca73c583eeda56698306225
http://europepmc.org/articles/PMC7802916
http://europepmc.org/articles/PMC7802916
Autor:
Eliot Lazar, Arin T Amin, Jay S. Pepose, Shane R Kannarr, Mina Sooch, Reda M Jaber, Konstantinos Charizanis, Paul M. Karpecki, Gerald D Horn, Marguerite B. McDonald, Alan R. Meyer, Shane Foster, Stephen Montaquila, Charles B. Slonim, Jonah E Yousif, Seth A Klapman
Publikováno v:
Optometry and vision science : official publication of the American Academy of Optometry. 98(3)
SIGNIFICANCE After a dilated eye examination, many patients experience symptoms of prolonged light sensitivity, blurred vision, and cycloplegia associated with pharmacological mydriasis. Phentolamine mesylate ophthalmic solution (PMOS) may expedite t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e451dad95bd3ffaf922ab9f157db3cb4
https://pubmed.ncbi.nlm.nih.gov/33633016
https://pubmed.ncbi.nlm.nih.gov/33633016
Autor:
Hassan Ashraf, Mini Manchanda, Apoorva Mohan, Konstantinos Charizanis, Christopher M. Chamberlain, Ranjan Batra, Moyi Li, Hannah Hong, Dustin J. Finn, Maurice S. Swanson, Kuang-Yung Lee, Laura P.W. Ranum, Hideko Kasahara, Sonisha Warren
Publikováno v:
EMBO Molecular Medicine
Myotonic dystrophy (DM) is a multi‐systemic disease that impacts cardiac and skeletal muscle as well as the central nervous system (CNS). DM is unusual because it is an RNA‐mediated disorder due to the expression of toxic microsatellite expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7308930cc90f8e12150f427d8f87222f
https://doi.org/10.1002/emmm.201303275
https://doi.org/10.1002/emmm.201303275
Publikováno v:
Human Molecular Genetics. 19:R77-R82
Nearly two decades have passed since the discovery that the expansion of microsatellite trinucleotide repeats is responsible for a prominent class of neurological disorders, including Huntington disease and fragile X syndrome. These hereditary diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2fea8afcc8d9702264f935338ec94dd
https://doi.org/10.1093/hmg/ddq132
https://doi.org/10.1093/hmg/ddq132
Publikováno v:
Neuroscience Letters. 466:99-102
The expansion of unstable microsatellites is the cause of a number of inherited neuromuscular and neurological disorders. While these expanded repeats can be located in either the coding or non-coding regions of genes, toxic RNA transcripts have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45630f34ae6a31751302eaf630bdd565
https://doi.org/10.1016/j.neulet.2009.07.079
https://doi.org/10.1016/j.neulet.2009.07.079
Autor:
Konstantinos Charizanis, Jing Ning, Amanda McNulty, Marta Gonzalez-Plasky, Matthew Carroll, Karl Hecker, Edward Jan, Emmanuel Kamberov
Publikováno v:
Cancer Research. 77:486-486
MicroRNA sequencing (miRNA-Seq) is a useful tool for aiding researchers in the examination of miRNA expression patterns, the characterization of novel miRNAs, and for uncovering miRNA-disease associations. Since miRNAs are also unusually well-preserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01574e36dba3b54c6b5e33b59e17b02f
https://doi.org/10.1158/1538-7445.am2017-486
https://doi.org/10.1158/1538-7445.am2017-486
Autor:
Marianne Goodwin, Moyi Li, Dustin J. Finn, Chaolin Zhang, Maurice S. Swanson, Apoorva Mohan, Konstantinos Charizanis, Charles A. Thornton, Krzysztof Sobczak, Mini Manchanda, Ranjan Batra
Publikováno v:
Molecular cell. 56(2)
Inhibition of muscleblind-like (MBNL) activity due to sequestration by microsatellite expansion RNAs is a major pathogenic event in the RNA-mediated disease myotonic dystrophy (DM). Although MBNL1 and MBNL2 bind to nascent transcripts to regulate alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4c450248b55c379e7287a2ca683683
https://pubmed.ncbi.nlm.nih.gov/25263597
https://pubmed.ncbi.nlm.nih.gov/25263597