Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Konstantinos, Thalassinos"'
Autor:
Annmary Paul Erinjeri, Xunyan Wang, Rhianna Williams, Riccardo Zenezini Chiozzi, Konstantinos Thalassinos, Johnathan Labbadia
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Increased activity of the heat shock factor, HSF-1, suppresses proteotoxicity and enhances longevity. However, the precise mechanisms by which HSF-1 promotes lifespan are unclear. Using an RNAi screen, we identify ubiquilin-1 (ubql-1) as an
Externí odkaz:
https://doaj.org/article/7a2b04bcfb114f56b65bf5fb9e168879
Autor:
Sapir Ofer, Fabian Blombach, Amanda M. Erkelens, Declan Barker, Zoja Soloviev, Samuel Schwab, Katherine Smollett, Dorota Matelska, Thomas Fouqueau, Nico van der Vis, Nicholas A. Kent, Konstantinos Thalassinos, Remus T. Dame, Finn Werner
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B that assemble into octameric nucleosome particles. Archaeal histones are dimeric and assemble on DNA into ‘hypernucleosome’ particles of varying sizes
Externí odkaz:
https://doaj.org/article/bc8d288a4e11401aafac8f1923d0ab56
Autor:
Yvette S Levray, Bianca Bana, Sarah J Tarr, Emilia J McLaughlin, Peter Rossi-Smith, Anita Waltho, Georgina H Charlton, Riccardo Zenezini Chiozzi, Colin R Straton, Konstantinos Thalassinos, Andrew R Osborne
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011281 (2023)
During the blood stage of a malaria infection, malaria parasites export both soluble and membrane proteins into the erythrocytes in which they reside. Exported proteins are trafficked via the parasite endoplasmic reticulum and secretory pathway, befo
Externí odkaz:
https://doaj.org/article/c0e9e53d05b548d882f89df60bb81168
Autor:
Felix J. Flomm, Timothy K. Soh, Carola Schneider, Linda Wedemann, Hannah M. Britt, Konstantinos Thalassinos, Søren Pfitzner, Rudolph Reimer, Kay Grünewald, Jens B. Bosse
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8 (2022)
Human Cytomegalovirus (HCMV) can infect a variety of cell types by using virions of varying glycoprotein compositions. It is still unclear how this diversity is generated, but spatio-temporally separated envelopment and egress pathways might play a r
Externí odkaz:
https://doaj.org/article/ebccca0378a44ceabc7c2203df05ecf3
Autor:
Antonio P. A. Ferreira, Alessandra Casamento, Sara Carrillo Roas, Els F. Halff, James Panambalana, Shaan Subramaniam, Kira Schützenhofer, Laura Chan Wah Hak, Kieran McGourty, Konstantinos Thalassinos, Josef T. Kittler, Denis Martinvalet, Emmanuel Boucrot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Here, the authors show that Cdk5 and GSK3β are negative regulators of fast Endophilin-mediated endocytosis (FEME).
Externí odkaz:
https://doaj.org/article/5f18132804ea4261bec70614b307e05c
Autor:
Tapasvi Modi, David Gervais, Stuart Smith, Julie Miller, Shaan Subramaniam, Konstantinos Thalassinos, Adrian Shepherd
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 17, Iss 3, Pp 747-758 (2021)
The manufacture of the UK Anthrax vaccine (AVP) focuses on the production of Protective Antigen (PA) from the Bacillus anthracis Sterne strain. Although used for decades, several of AVP’s fundamental properties are poorly understood, including its
Externí odkaz:
https://doaj.org/article/b0e998a7de564fcaaeeefd31fd3c0691
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Peptide toxins that adopt the inhibitory cystine knot (ICK) scaffold have very stable three-dimensional structures as a result of the conformational constraints imposed by the configuration of the three disulfide bonds that are the hallmark of this f
Externí odkaz:
https://doaj.org/article/cbc9457e544e4ab4a814412e0b5ee55b
Autor:
Tommaso Tosi, Fumiya Hoshiga, Charlotte Millership, Rahul Singh, Charles Eldrid, Delphine Patin, Dominique Mengin-Lecreulx, Konstantinos Thalassinos, Paul Freemont, Angelika Gründling
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007537 (2019)
c-di-AMP is an important second messenger molecule that plays a pivotal role in regulating fundamental cellular processes, including osmotic and cell wall homeostasis in many Gram-positive organisms. In the opportunistic human pathogen Staphylococcus
Externí odkaz:
https://doaj.org/article/d723f21044c24d7f807389cc25aa03cd
Autor:
Scott Gardner, Michele C. Darrow, Natalya Lukoyanova, Konstantinos Thalassinos, Helen R. Saibil
The bacterial chaperonin GroEL-GroES promotes protein folding through ATP-regulated cycles of substrate protein binding, encapsulation, and release. Here, we have used cryoEM to determine structures of GroEL, GroEL-ADP.BeF3, and GroEL-ADP.AlF3-GroES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24317f24acf8dba81f1ccde9da36ad3f
https://doi.org/10.1101/2023.05.29.542693
https://doi.org/10.1101/2023.05.29.542693
Native top-down mass spectrometry is a powerful approach for analyzing proteoforms, but one which largely disregards protein conformation. We report a new ion mobility-enabled method for performing native top-down MS in a conformation-specific manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fab1a59fd0f81c2d85858abbf525fdb0
https://doi.org/10.26434/chemrxiv-2023-54dg1
https://doi.org/10.26434/chemrxiv-2023-54dg1