Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Konstantina Rowald"'
Autor:
Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres, Rocío Sotillo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
PLK1 is a mitotic regulator overexpressed in cancer; however, whether this overexpression causally contributes to tumor development is unclear. Here the authors produce an inducible mouse model to overexpress PLK1 and show that actually this can act
Externí odkaz:
https://doaj.org/article/624e442f805148c5bac60f63e764f010
Autor:
Lorena Salgueiro, Christopher Buccitelli, Konstantina Rowald, Kalman Somogyi, Sridhar Kandala, Jan O Korbel, Rocio Sotillo
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Abstract Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is not clear. Using
Externí odkaz:
https://doaj.org/article/225029ac68f7435d9344bd21f7538671
Autor:
Konstantina Rowald, Martina Mantovan, Joana Passos, Christopher Buccitelli, Balca R. Mardin, Jan O. Korbel, Martin Jechlinger, Rocio Sotillo
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2679-2691 (2016)
Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages. Here, we show that simultaneous overexpression of the mitotic chec
Externí odkaz:
https://doaj.org/article/b18daaf5285944e4bbc910a431353d51
Autor:
Kalman Somogyi, Konstantina Rowald, Christopher Buccitelli, Jan O. Korbel, Lorena Salgueiro, Rocio Sotillo, Sridhar Kandala
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is not clear. Using a CIN mo
Autor:
Nicholas McGranahan, Guillermo de Cárcer, Konstantina Rowald, Beatriz Escobar, Rocio Sotillo, Alba de Martino, Pablo Montanes, Marcos Malumbres, Sharavan Vishaan Venkateswaran, Aicha El Bakkali, Kalman Somogyi, Manuel Sanclemente, Lorena Salgueiro
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors, being frequently considered as an oncogene and an attractive cancer target. However, its contribution to tumor development is unclear. Using a new inducible knock-in mouse
Autor:
Jan O. Korbel, Martina Mantovan, Konstantina Rowald, Martin Jechlinger, Christopher Buccitelli, Balca R. Mardin, Joana Passos, Rocio Sotillo
Publikováno v:
Cell Reports
Cell Reports, Vol 15, Iss 12, Pp 2679-2691 (2016)
Cell Reports, Vol 15, Iss 12, Pp 2679-2691 (2016)
Summary Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages. Here, we show that simultaneous overexpression of the mito
Autor:
Nicholas McGranahan, Sharavan Vishaan Venkateswaran, Aicha El Bakkali, Beatriz Escobar, Manuel Sanclemente, Guillermo de Cárcer, Lorena Salgueiro, Marcos Malumbres, Pablo Montanes, Kalman Somogyi, Rocio Sotillo, Alba de Martino, Konstantina Rowald
Polo-like kinase 1 (Plk1) is a protein kinase currently considered as an attractive cancer target due to its critical role in the cell division cycle. Plk1 is overexpressed in a wide spectrum of human tumors, being frequently considered as an oncogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c782844326913d59441c2f65c80a226e
Autor:
Konstantina Rowald, Rocio Sotillo
Publikováno v:
Cell Cycle
Fighting cancer is like fighting evolution. Its variant genetic background and its easy adaptability made it an exasperating case for science. Today we know that one of the reasons behinds its genetic flexibility is the occurrence of errors during ch