Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6.

Autor: Nichole M Danzl, Seihwan Jeong, Yongwon Choi, Konstantina Alexandropoulos

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e86129 (2014)

Thymic epithelial cells (TECs) are critical for the normal development and function of the thymus. Here, we examined the developmental stages of TECs using quantitative assessment of the cortical and medullary markers Keratin 5 and Keratin 8 (K5 and

Externí odkaz: https://doaj.org/article/7e86550e9f8b47e68d82d3005d3114eb

Medullary thymic epithelial cells and CD8α + dendritic cells coordinately regulate central tolerance but CD8α + cells are dispensable for thymic regulatory T cell production

Autor: Miriam Merad, Adeeb Rahman, Anthony J. Bonito, Konstantina Alexandropoulos, Seihwan Jeong, Huabao Xiong, Olivier Herbin, Erica G. Weinstein

Publikováno v: Journal of Autoimmunity. 75:141-149

In the thymus, antigen presenting cells (APCs) namely, medullary thymic epithelial cells (mTECs) and thymic dendritic cells (tDCs) regulate T cell tolerance through elimination of autoreactive T cells and production of thymic T regulatory (tTreg) cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef87c0606d22c2de1c53309e022b08aa
https://doi.org/10.1016/j.jaut.2016.08.002

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

Autor: Dilara McCauley, Patrizia Casaccia, Stephanie Albrecht, Belén de la Hera, Sharon Shacham, Oscar G. Vidaurre, Yuh Min Chook, Grahame J. Kidd, Tanja Kuhlmann, Konstantina Alexandropoulos, Olivier Herbin, Jeffery D. Haines, Ho Yee Joyce Fung, Gregory Moy, Qingxiang Sun

Publikováno v: Nature Neuroscience. 18:511-520

Axonal damage has been associated with aberrant protein trafficking. We examined a newly characterized class of compounds that target nucleo-cytoplasmic shuttling by binding to the catalytic groove of the nuclear export protein XPO1 (also known as CR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bff9c052c6d59d36f24cc4a452d5bffd
https://doi.org/10.1038/nn.3953

Cas Adaptor Proteins Organize the Retinal Ganglion Cell Layer Downstream of Integrin Signaling

Autor: Sachiko Seo, Alex L. Kolodkin, Mineo Kurokawa, Martin M. Riccomagno, Colleen M. Brady, Lu O. Sun, Konstantina Alexandropoulos

Publikováno v: Neuron, vol 81, iss 4

Stratification of retinal neuronal cell bodies and lamination of their processes provide a scaffold upon which neural circuits can be built. However, the molecular mechanisms that direct retinal ganglion cells (RGCs) to resolve into a single-cell ret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ab1b8a2fb3762a26a83fc46d6c67ed
https://doi.org/10.1016/j.neuron.2014.01.036

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

Autor: Luis C. Santos, Michael L. Dustin, Sudha Kumari, Michael Cammer, Thomas Iskratsch, David A. Blair, Michael P. Sheetz, Olivier Herbin, Konstantina Alexandropoulos

Publikováno v: Santos, L C, Blair, D A, Kumari, S, Iskratsch, T, Cammer, M, Herbin, O, Alexandropoulos, K, Dustin, M L & Sheetz, M P 2016, ' Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability ', Immunology and Cell Biology . https://doi.org/10.1038/icb.2016.61
Immunology and Cell Biology

The immunological synapse formed between a T‐cell and an antigen‐presenting cell is important for cell–cell communication during T‐cell‐mediated immune responses. Immunological synapse formation begins with stimulation of the T‐cell recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5e1617841cfa84ea7d79cef8164ae9
https://pubmed.ncbi.nlm.nih.gov/27645156