Brain vulnerability and viability after ischaemia

Autor: Christoph Benk, Stefano G. Daniele, Konstantin Alexander Hossmann, David Dellal, Jan-Steffen Pooth, Georg Trummer, Kevin T Gobeske, Zvonimir Vrselja, David Andrijevic, Domagoj Damjanovic, Friedhelm Beyersdorf, Nenad Sestan

Publikováno v: Nature reviews. Neuroscience. 22(9)

The susceptibility of the brain to ischaemic injury dramatically limits its viability following interruptions in blood flow. However, data from studies of dissociated cells, tissue specimens, isolated organs and whole bodies have brought into questio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6212b86c6bcca194a801aa3d71f9b231
https://pubmed.ncbi.nlm.nih.gov/34290397

Heterozygosity for the mutated X-chromosome-linked L1 cell adhesion molecule gene leads to increased numbers of neurons and enhanced metabolism in the forebrain of female carrier mice

Autor: Konstantin-Alexander Hossmann, Janinne Sylvie Schmid, Günter Mies, Alexander G. Nikonenko, Zhang Ling, Christian Bernreuther, Igor Jakovcevski, Melitta Schachner

Publikováno v: Brain Structure and Function. 218:1375-1390

Mutations in the X-chromosomal L1CAM gene lead to severe neurological deficits. In this study, we analyzed brains of female mice heterozygous for L1 (L1+/-) to gain insights into the brain structure of human females carrying one mutated L1 allele. Fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111568b399e89d501347a714a0cde14c
https://doi.org/10.1007/s00429-012-0463-9

Induction of Cerebral Arteriogenesis Leads to Early-Phase Expression of Protease Inhibitors in Growing Collaterals of the Brain

Autor: Henning Witt, Anja Bondke, Philipp Hillmeister, Joachim Jankowski, André Duelsner, Ivo Buschmann, Kerstin Lehmann, Clemens Gruber, Hans-Jörg Busch, Patricia Ruiz-Noppinger, Konstantin-Alexander Hossmann

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 28:1811-1823

Cerebral arteriogenesis constitutes a promising therapeutic concept for cerebrovascular ischaemia; however, transcriptional profiles important for therapeutic target identification have not yet been investigated. This study aims at a comprehensive ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33f54a29239c4f6d5ecb6469745edf5
https://doi.org/10.1038/jcbfm.2008.69

Stroke Research Priorities for the Next Decade – A Representative View of the European Scientific Community

Autor: Antoni Dávalos, Stephen Meairs, Zoltan Nagy, Peter M. Rothwell, Ulrich Dirnagl, Britta Engelhardt, Michael G. Hennerici, Gennaro De Libero, Olle Lindvall, Gian Luigi Lenzi, Markku Kaste, Matthias Endres, Anna Maria Fernàndez Planas, Konstantin Alexander Hossmann, Jari Koistinaho, Alan Evans, Arne Hagen, Jean-Claude Baron, Pierre Amarenco, Daiva Rastenyte, Anna Członkowska, Denis Vivien, José M. Ferro, Jürgen Reess, James McCulloch, Rick M. Dijkhuizen, Nils Wahlgren

Publikováno v: Meairs, Stephen; Wahlgren, Nils; Dirnagl, Ulrich; Lindvall, Olle; Rothwell, Peter; Baron, Jean-Claude; Hossmann, Konstantin; Engelhardt, Britta; Ferro, José; McCulloch, James; Kaste, Markku; Endres, Matthias; Koistinaho, Jari; Planas, Anna; Vivien, Denis; Dijkhuizen, Rick; Czlonkowska, Anna; Hagen, Arne; Evans, Alan; De Libero, Gennaro; ... (2006). Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovascular diseases, 22(2-3), pp. 75-82. Basel: Karger 10.1159/000093098

science, stroke research and industry. The primary objective of the workshop was to exchange views on the topic of stroke and to identify research activities that could potentially result in major advances in the areas of stroke prevention, treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb322f78d6fd17a7e9baa3a8fea3369
https://doi.org/10.1159/000093098

Granulocyte-macrophage colony-stimulating factor-induced arteriogenesis reduces energy failure in hemodynamic stroke

Autor: Günter Mies, Ivo Buschmann, Edda Schneeloch, Hans-Jörg Busch, Konstantin-Alexander Hossmann

Publikováno v: Proceedings of the National Academy of Sciences. 101:12730-12735

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a powerful arteriogenic factor in the hypoperfused rat brain. To test the pathophysiological relevance of this response, the influence of GM-CSF on brain energy state was investigated in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702e0d5035986ee754d65d8668185f9b
https://doi.org/10.1073/pnas.0404880101