Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Konstantin Virnik"'
Autor:
Konstantin Virnik, Margherita Rosati, Alexei Medvedev, Aaron Scanlan, Gabrielle Walsh, Frances Dayton, Kate E Broderick, Mark Lewis, Yvonne Bryson, Jeffrey D Lifson, Ruth M Ruprecht, Barbara K Felber, Ira Berkower
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0228163 (2020)
Anti-retroviral therapy (ART) has been highly successful in controlling HIV replication, reducing viral burden, and preventing both progression to AIDS and viral transmission. Yet, ART alone cannot cure the infection. Even after years of successful t
Externí odkaz:
https://doaj.org/article/a5d64ab2c3e94bdd92d5f3a09c3ae780
Autor:
Gabrielle Walsh, Wenshuo Zhou, Alexei Medvedev, Barbara K. Felber, Sanjai Kumar, Jasper Perry-Anderson, Victoria Majam, Konstantin Virnik, Ira Berkower
Publikováno v:
Biochem Biophys Res Commun
There is an urgent need for a malaria vaccine that can prevent severe disease in young children and adults. Despite earlier work showing an immunological mechanism for preventing infection and reducing disease severity, there is currently no reliable
Publikováno v:
The Journal of Immunology. 206:114.17-114.17
We have developed a series of live viral vectors based on the live attenuated rubella vaccine strain RA27/3. These vectors can express a variety of heterologous vaccine antigens without interfering with vector growth or stable antigen expression. The
Autor:
Leonidas Stamatatos, Konstantin Virnik, Andrew T. McGuire, Edmund Nesti, Alexei Medvedev, Russell Vassell, Ira Berkower, Aaron Scanlan, Cody Dail
Publikováno v:
Vaccine. 36(34)
Following HIV infection, most people make antibodies to gp120 and gp41, yet only a few make broadly neutralizing antibodies that target key antigenic sites on the envelope glycoproteins. The induction of broadly neutralizing antibodies by immunizatio
Autor:
Candido Alicea, Niranjan Y. Sardesai, Barbara K. Felber, Konstantin Virnik, Antonio Valentin, Margherita Rosati, Viraj Kulkarni, George N. Pavlakis, Max Hockenbury, Ira Berkower
Publikováno v:
Vaccine
Live-attenuated rubella vaccine strain RA27/3 has been demonstrated to be safe and immunogenic in millions of children. The vaccine strain was used to insert SIV gag sequences and the resulting rubella vectors were tested in rhesus macaques alone and
Autor:
Barbara K. Felber, Yisheng Ni, Cody Dail, Edmund Nesti, Max Hockenbury, Konstantin Virnik, Ira Berkower, William R. Schief
Publikováno v:
Vaccine
Infection with HIV or SIV often elicits a potent immune response to viral antigens. This includes T cells and antibodies specific for Gag and Env antigens. In contrast, when given as a vaccine, the same antigens have been weak immunogens, unable to e
Publikováno v:
Vaccine. 31:2119-2125
Despite the urgent need for an HIV vaccine, its development has been hindered by virus variability, weak immunogenicity of conserved epitopes, and limited durability of the immune response. For other viruses, difficulties with immunogenicity were ove
Publikováno v:
BMC Microbiology
Background It is unclear how DNA is packaged in a bacterial cell in the absence of nucleosomes. To investigate the initial level of DNA condensation in bacterial nucleoid we used in vivo DNA digestion coupled with high-throughput sequencing of the di
Publikováno v:
Vaccine. 28:1181-1187
Live, attenuated rubella vaccine has been used successfully for many years. By expressing additional viral antigens in rubella, we could expand its range and utility as a live, replicating viral vector. Previously, limitations on insert size and stab
Publikováno v:
Virology. 377(2):330-338
Different isolates of HIV-1 are known to vary in antibody binding and sensitivity to neutralization. In response to selective pressure, the virus may conceal important neutralizing determinants, such as the CD4 binding site on gp120, through steric h