Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Konstantin V. Kudryavtsev"'
Publikováno v:
Antibiotics, Vol 11, Iss 12, p 1836 (2022)
Prevention of bacterial adhesion is one of the most important antivirulence strategies for meeting the global challenge posed by antimicrobial resistance. We aimed to investigate the influence of a peptidic S. aureus sortase A inhibitor on bacterial
Externí odkaz:
https://doaj.org/article/628e65933d194b6e8cf0d04da6d617de
Publikováno v:
Molecules, Vol 27, Iss 23, p 8182 (2022)
Sortase A (SrtA) of Staphylococcus aureus is a well-defined molecular target to combat the virulence of these clinically important bacteria. However up to now no efficient drugs or even clinical candidates are known, hence the search for such drugs i
Externí odkaz:
https://doaj.org/article/a8a14655069a458fa25a41c217461704
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 5, Pp 537-539 (2019)
The title compound, C38H50N2O7, represents a chiral β-proline dipeptide. Corresponding stereogenic centres of constituting pyrrolidine units have opposite absolute configurations. The central amide fragment is planar within 0.1 Å and adopts a Z con
Externí odkaz:
https://doaj.org/article/62bf729bae704e7b8f91101230e18365
Publikováno v:
Molecules, Vol 26, Iss 24, p 7677 (2021)
Sortase A (SrtA) of Staphylococcus aureus has been identified as a promising target to a new type of antivirulent drugs, and therefore, the design of lead molecules with a low nanomolar range of activity and suitable drug-like properties is important
Externí odkaz:
https://doaj.org/article/185fdcfaafdd42828c3dc122cb962dd8
Autor:
Alexey B. Mantsyzov, Oleg Y. Savelyev, Polina M. Ivantcova, Stefan Bräse, Konstantin V. Kudryavtsev, Vladimir I. Polshakov
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Synthetic β-peptides are potential functional mimetics of native α-proteins. A recently developed, novel, synthetic approach provides an effective route to the broad group of β-proline oligomers with alternating patterns of stereogenic centers. Co
Externí odkaz:
https://doaj.org/article/d872ab658dee42c6815dcaaa041923a8
Autor:
Konstantin V. Kudryavtsev, Anna O. Markevich, Oleksandr V. Virchenko, Tetyana M. Falalyeyeva, Tetyana V. Beregova, Lyudmyla I. Ostapchenko, Dmitry V. Zabolotnev, Nikolay S. Zefirov
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity wer
Externí odkaz:
https://doaj.org/article/0bb4fccfb4aa4a6f94849aeb97b1dfae
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 2, Pp o161-o162 (2013)
In the title compound, C16H15F3N2O4, the relative stereochemistry of the four stereogenic C atoms has been determined. The carboxymethyl and 2-(trifluoromethyl)phenyl substituents of the pyrrolidine cycle have a cis mutual arrangement. The five-membe
Externí odkaz:
https://doaj.org/article/bde90914f60146fca5e59b70d8fd25aa
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 2, Pp o238-o238 (2013)
The title compound, C13H8F3N3S, consists of three linked aromatic rings. The whole molecule (except for the three F atoms) is planar to within 0.225 (2) Å. In the crystal, adjacent molecules are linked into chains along the ac diagonal by weak C—H
Externí odkaz:
https://doaj.org/article/8733d644dd34441490d5069e1530ac4a
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 8, Pp o2373-o2373 (2012)
In the title compound, C16H23ClN2O, both six-membered rings adopt chair conformations, thus allowing the formation of an intramolecular N—H...N hydrogen bond. In the crystal, adjacent molecules are combined into chains running along the ac diagonal
Externí odkaz:
https://doaj.org/article/20f0b8f53c5748ff9c79ffc2e30ad198
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 6, Pp o1718-o1718 (2012)
In the title compound, C14H13N3O2, the relative stereochemistry of the three stereogenic C atoms has been determined. In the crystal, N—H...O hydrogen bonds link the molecules into chains of inversion dimers running along the b axis.
Externí odkaz:
https://doaj.org/article/bf56505c8828412ca87e22e802a04048