Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Konstantin V Salojin"'
Autor:
Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://doaj.org/article/1dff52e3692941429b8b20d7536589fd
Autor:
William W. Cruikshank, Wei Chen, Konstantin V. Salojin, Craig Meagher, Qing Sheng Mi, Noah Horst, Josh Beilke, G A Arreaza, Terry L. Delovitch
Publikováno v:
Diabetes
OBJECTIVE The progressive infiltration of pancreatic islets by lymphocytes is mandatory for development of autoimmune type 1 diabetes. This inflammatory process is mediated by several mediators that are potential therapeutic targets to arrest develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5189609b404eafa2e265a8b4d2b14d7f
https://doi.org/10.2337/db09-0131
https://doi.org/10.2337/db09-0131
Publikováno v:
Diabetes. 53:2003-2011
B-cells proliferate after B-cell receptor (BCR) stimulation and are deleted by activation-induced cell death (AICD) during negative selection. We report that B-cells from type 1 diabetes−susceptible NOD and type 1 diabetes−resistant but insulitis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7c2deb55db88566e3f39f2bb95d8b0
https://doi.org/10.2337/diabetes.53.8.2003
https://doi.org/10.2337/diabetes.53.8.2003
Autor:
T. Craig Meagher, Terry L. Delovitch, Peter Zucker, Konstantin V. Salojin, Wei Chen, Marsha Grattan, Qing Sheng Mi
Publikováno v:
Endocrinology. 145:627-638
IGF-I regulates islet β-cell growth, survival, and metabolism and protects against type 1 diabetes (T1D). However, the therapeutic efficacy of free IGF-I may be limited by its biological half-life in vivo. We investigated whether prolongation of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5a25f284065b5481a2ef78c889a4c7
https://doi.org/10.1210/en.2003-1274
https://doi.org/10.1210/en.2003-1274
Autor:
Jian Xin Gao, Craig Meagher, Konstantin V. Salojin, Mark J. Cameron, Wen Yang, Guillermo A. Arreaza, B. M. Gill, Terry L. Delovitch, Jian Zhang, Qing Sheng Mi
Publikováno v:
Clinical Immunology. 107:103-115
Activation-induced cell death (AICD) is a mechanism of homeostasis that limits the clonal expansion of autoreactive T cells and regulates central and peripheral tolerance. In nonobese diabetic (NOD) mice, defects in central and peripheral tolerance a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ac138b5d8b4f4ce739fa6c3c8a2549
https://doi.org/10.1016/s1521-6616(03)00049-4
https://doi.org/10.1016/s1521-6616(03)00049-4
Autor:
Jason Allen, Kenneth G. Carson, Brian D. Hamman, Amin Al-Shami, Peter Vogel, Kanchan G. Jhaver, Carrie Wilkins, Wei-Chun Chang, Brian Zambrowicz, Kenneth A. Platt, Alan Main, Ann Marie Digeorge-Foushee, Tamas Oravecz, David J. Augeri, R. Read, Konstantin V. Salojin, Jonathan C. Swaffield, Suma Gopinathan, Theodore C. Jessop, Jeffrey T. Bagdanoff, Nita Patel, Alan Wilson, Jeannette Crisostomo, Amr Nouraldeen, Julia Zhou
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
PLoS ONE
PLoS ONE
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab72ed43ba6f3801b3c10d3473e5d2d
http://europepmc.org/articles/PMC4031148?pdf=render
http://europepmc.org/articles/PMC4031148?pdf=render
Publikováno v:
Journal of Biological Chemistry. 275:5966-5975
Translocation of the SOS and Vav GDP/GTP exchange factors proximal to Ras and Rac GTPases localized in the plasma membrane glycolipid-enriched microdomains is a pivotal step required for T cell antigen receptor-induced T cell activation. Here we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc90e3f049dfca3e87e88311c4af998f
https://doi.org/10.1074/jbc.275.8.5966
https://doi.org/10.1074/jbc.275.8.5966
Publikováno v:
The Journal of Immunology. 163:844-853
CD28 costimulation amplifies TCR-dependent signaling in activated T cells, however, the biochemical mechanism(s) by which this occurs is not precisely understood. The small GTPase Rac-1 controls the catalytic activity of the mitogen-activated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea3f6f3ebf6061dd18362c7c0112b42e
https://doi.org/10.4049/jimmunol.163.2.844
https://doi.org/10.4049/jimmunol.163.2.844
Autor:
Jian Zhang, Konstantin V. Salojin, Jian-Xin Gao, Mark J. Cameron, Isabelle Bergerot, Terry L. Delovitch
Publikováno v:
The Journal of Immunology. 162:3819-3829
Optimal T cell activation requires two signals, one generated by TCR and another by the CD28 costimulatory receptor. In this study, we investigated the regulation of costimulation-induced mitogen-activated protein kinase (MAPK) activation in primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38131acb4e646ebb47f51024dd25af2c
https://doi.org/10.4049/jimmunol.162.7.3819
https://doi.org/10.4049/jimmunol.162.7.3819
Autor:
Konstantin V. Salojin, Peter Vogel, Weimei Sun, Colin Lin, Lindsay Duncan, R. Read, Richard H. Finnell, Qingyun Liu, Robert M. Cabrera, Ken A. Platt, Tamas Oravecz, Wei-Chun Chang
Publikováno v:
Blood. 117(18)
The human proton coupled folate transporter (PCFT) is involved in low pH-dependent intestinal folate transport. In this report, we describe a new murine model of the hereditary folate malabsorption syndrome that we developed through targeted disrupti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54695294a2b5a138d7dd91301d8f67e7
https://pubmed.ncbi.nlm.nih.gov/21546467
https://pubmed.ncbi.nlm.nih.gov/21546467