Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Konstantin V, Kudryavtsev"'
Publikováno v:
Antibiotics, Vol 11, Iss 12, p 1836 (2022)
Prevention of bacterial adhesion is one of the most important antivirulence strategies for meeting the global challenge posed by antimicrobial resistance. We aimed to investigate the influence of a peptidic S. aureus sortase A inhibitor on bacterial
Externí odkaz:
https://doaj.org/article/628e65933d194b6e8cf0d04da6d617de
Publikováno v:
Molecules, Vol 27, Iss 23, p 8182 (2022)
Sortase A (SrtA) of Staphylococcus aureus is a well-defined molecular target to combat the virulence of these clinically important bacteria. However up to now no efficient drugs or even clinical candidates are known, hence the search for such drugs i
Externí odkaz:
https://doaj.org/article/a8a14655069a458fa25a41c217461704
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 5, Pp 537-539 (2019)
The title compound, C38H50N2O7, represents a chiral β-proline dipeptide. Corresponding stereogenic centres of constituting pyrrolidine units have opposite absolute configurations. The central amide fragment is planar within 0.1 Å and adopts a Z con
Externí odkaz:
https://doaj.org/article/62bf729bae704e7b8f91101230e18365
Publikováno v:
Molecules, Vol 26, Iss 24, p 7677 (2021)
Sortase A (SrtA) of Staphylococcus aureus has been identified as a promising target to a new type of antivirulent drugs, and therefore, the design of lead molecules with a low nanomolar range of activity and suitable drug-like properties is important
Externí odkaz:
https://doaj.org/article/185fdcfaafdd42828c3dc122cb962dd8
Autor:
Alexey B. Mantsyzov, Oleg Y. Savelyev, Polina M. Ivantcova, Stefan Bräse, Konstantin V. Kudryavtsev, Vladimir I. Polshakov
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Synthetic β-peptides are potential functional mimetics of native α-proteins. A recently developed, novel, synthetic approach provides an effective route to the broad group of β-proline oligomers with alternating patterns of stereogenic centers. Co
Externí odkaz:
https://doaj.org/article/d872ab658dee42c6815dcaaa041923a8
Autor:
Nadezhda I. Fedotcheva, Eduard E. Varpetyan, Anna A. Kirsanova, N. L. Shimanovskii, Mikhail N. Sokolov, Konstantin V. Kudryavtsev, T. A. Fedotcheva
Publikováno v:
ChemistrySelect. 5:11467-11470
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bd8b3bd37a202011e173360923c8aa2
https://doi.org/10.1002/slct.202003345
https://doi.org/10.1002/slct.202003345
Autor:
Vladimir I. Polshakov, Polina M. Ivantcova, Stefan Bräse, Mikhail N. Sokolov, Konstantin V. Kudryavtsev, Alexey B. Mantsyzov
Publikováno v:
The Journal of Organic Chemistry. 85:8865-8871
All possible variants of β-proline functionalized tripeptides consisting of homo/hetero chiral monomeric all-cis 5-arylpyrrolidine-2,4-dicarboxylate units were synthesized for the first time by a n...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b85035697b5250aa602ac51cee7d80
https://doi.org/10.1021/acs.joc.0c00598
https://doi.org/10.1021/acs.joc.0c00598
Autor:
N. I. Sheina, Nadezhda I. Fedotcheva, T. A. Fedotcheva, E. D. Sveshnikova, Mikhail N. Sokolov, Konstantin V. Kudryavtsev, N. L. Shimanovskii
Publikováno v:
Pharmaceutical Chemistry Journal. 54:119-125
New mepregenol 17-acetate derivatives with potential cytotoxicity were synthesized. Mepregenol 17-acetate 3-acrylate (III) was shown to exhibit potent cytotoxicity although the ester of N-benzylpyrrolidine-3-carboxylic acid (IV) had weaker activity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f311518cdc77ef4cf6ea9942e7ac4c1
https://doi.org/10.1007/s11094-020-02167-1
https://doi.org/10.1007/s11094-020-02167-1
Autor:
Konstantin V. Kudryavtsev, Anna O. Markevich, Oleksandr V. Virchenko, Tetyana M. Falalyeyeva, Tetyana V. Beregova, Lyudmyla I. Ostapchenko, Dmitry V. Zabolotnev, Nikolay S. Zefirov
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity wer
Externí odkaz:
https://doaj.org/article/0bb4fccfb4aa4a6f94849aeb97b1dfae
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 2, Pp o161-o162 (2013)
In the title compound, C16H15F3N2O4, the relative stereochemistry of the four stereogenic C atoms has been determined. The carboxymethyl and 2-(trifluoromethyl)phenyl substituents of the pyrrolidine cycle have a cis mutual arrangement. The five-membe
Externí odkaz:
https://doaj.org/article/bde90914f60146fca5e59b70d8fd25aa