Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Konstantin Tsinman"'
Autor:
Szabina Kádár, Petra Tőzsér, Brigitta Nagy, Attila Farkas, Zsombor K. Nagy, Oksana Tsinman, Konstantin Tsinman, Dóra Csicsák, Gergely Völgyi, Krisztina Takács-Novák, Enikő Borbás, Bálint Sinkó
Publikováno v:
The AAPS Journal. 24
The work aimed to develop the Absorption Driven Drug Formulation (ADDF) concept, which is a new approach in formulation development to ensure that the drug product meets the expected absorption rate. The concept is built on the solubility-permeabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21a2760169fbfad2a1127c3af785185a
https://doi.org/10.1208/s12248-021-00668-9
https://doi.org/10.1208/s12248-021-00668-9
Autor:
Szabina, Kádár, Petra, Tőzsér, Brigitta, Nagy, Attila, Farkas, Zsombor K, Nagy, Oksana, Tsinman, Konstantin, Tsinman, Dóra, Csicsák, Gergely, Völgyi, Krisztina, Takács-Novák, Enikő, Borbás, Bálint, Sinkó
Publikováno v:
The AAPS journal. 24(1)
The work aimed to develop the Absorption Driven Drug Formulation (ADDF) concept, which is a new approach in formulation development to ensure that the drug product meets the expected absorption rate. The concept is built on the solubility-permeabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ebda0b95d3e1bb09cafa0b0823805ec
https://pubmed.ncbi.nlm.nih.gov/34988721
https://pubmed.ncbi.nlm.nih.gov/34988721
Autor:
Gergely Völgyi, Hajnalka Pataki, Enikő Borbás, Bálint Sinkó, Konstantin Tsinman, Krisztina Takács-Novák, Oksana Tsinman, Dóra Csicsák, Szabina Kádár
Publikováno v:
Molecular Pharmaceutics. 16:4121-4130
In this work, two different approaches have been developed to predict the food effect and the bioequivalence of marketed itraconazole (ITRA) formulations. Kinetic solubility and simultaneous dissolution-permeation tests of three (ITRA) formulations (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e751df8dcb31c0c1c3dd168a6a778e
https://doi.org/10.1021/acs.molpharmaceut.9b00406
https://doi.org/10.1021/acs.molpharmaceut.9b00406
Autor:
Marilyn N. Martinez, Raafat Fahmy, Mansoor A. Khan, Xavier Pepin, Jonathan P. Mochel, Sara Carlert, Patrick J. Sinko, Masoud Jamei, Viera Lukacova, D Pade, Murat Cirit, Sid Bhoopathy, Konstantin Tsinman, David C. Sperry, Talia Flanagan, Maria Vertzoni, Christos Reppas, Ben Forbes
Publikováno v:
Dissolution Technologies. 26:38-66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7515f38c0bc917b312bc68a856afd67
https://doi.org/10.14227/dt260319p38
https://doi.org/10.14227/dt260319p38
Autor:
Konstantin Tsinman, Oksana Tsinman, Enikő Borbás, Bálint Sinkó, Krisztina Takács-Novák, Petra Tőzsér, Zsombor Kristóf Nagy, Gergely Völgyi
Publikováno v:
Molecular Pharmaceutics. 15:3308-3317
The aim of this research was to investigate the driving force of membrane transport through size-exclusion membranes and to provide a concentration-based mathematical description of it to evaluate whether it can be an alternative for lipophilic membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6e4472a9b6263d3f08be1fb9ec257a
https://doi.org/10.1021/acs.molpharmaceut.8b00343
https://doi.org/10.1021/acs.molpharmaceut.8b00343
Autor:
Bernard Van Eerdenbrugh, Bernd Ulrich Riebesehl, Arnaud Grandeury, Oksana Tsinman, Saijie Zhu, Konstantin Tsinman, Michael Juhnke, Ram Lingamaneni
Publikováno v:
Pharmaceutical Research. 35
The goal of the study was to evaluate a miniaturized dissolution-permeation apparatus (μFLUX™ apparatus) for its ability to benchmark several itraconazole (ITZ) formulations for which in vivo PK data was available in the literature. Untreated and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d70638e99bda9edf3325bb37b212d1
https://doi.org/10.1007/s11095-018-2440-3
https://doi.org/10.1007/s11095-018-2440-3
Publikováno v:
AAPS PharmSciTech. 19(7)
This study described a pH-gradient dissolution method combined with flux measurements as an in vitro tool for assessing the risk of bioavailability reduction due to drug-drug interactions (DDI) caused by acid reducing agents (ARAs). The device incorp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5e1ffb6d7ea4f67e55523dd116d132
https://pubmed.ncbi.nlm.nih.gov/30209787
https://pubmed.ncbi.nlm.nih.gov/30209787
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 114:88-96
The extent of ionization of a drug molecule at different pH values can be characterized by its pKa (acid dissociation constants). It is an important parameter in pharmaceutical development to rationalize the physiochemical and biopharmaceutical prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bb09cd1ee875e3d6e4bd20305eb954
https://doi.org/10.1016/j.jpba.2015.05.009
https://doi.org/10.1016/j.jpba.2015.05.009
Autor:
Bálint Sinkó, Balázs Farkas, Attila Balogh, Konstantin Tsinman, Oksana Tsinman, Brigitta Nagy, Zsombor Kristóf Nagy, Enikő Borbás
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 114
In this study, brand and four generic formulations of telmisartan, an antihypertensive drug, were used in in vitro simultaneous dissolution-absorption, investigating the effect of different formulation additives on dissolution and on absorption throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75d504077d7e12eafca5cf6cdc16d3e
https://pubmed.ncbi.nlm.nih.gov/29305981
https://pubmed.ncbi.nlm.nih.gov/29305981
