Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Konstantin Piatkov"'
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
A sensitive and specific bioanalytical method was required to measure the exposure of a LAGA-mutated surrogate mouse IgG2a monoclonal antibody in mouse plasma, but the lack of highly specific reagents for the LAGA mutant hindered the development of a
Externí odkaz:
https://doaj.org/article/f29ac644e16c4755a15767df2a17402a
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1009715 (2022)
Bispecific T cell engagers (TCEs) are an emerging anti-cancer modality that redirects cytotoxic T cells to tumor cells expressing tumor-associated antigens (TAAs), thereby forming immune synapses to exert anti-tumor effects. Designing pharmacokinetic
Externí odkaz:
https://doaj.org/article/6aea3f06713f4fb38c4539558cf0b7da
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 903 (2020)
Recognition of danger signals by a cell initiates a powerful cascade of events generally leading to inflammation. Inflammatory caspases and several other proteases become activated and subsequently cleave their target proinflammatory mediators. The i
Externí odkaz:
https://doaj.org/article/fd55a077d9c3496ea2c243cd33ba1cba
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 612 (2020)
Caspases are proteases conserved throughout Metazoans and responsible for initiating and executing the apoptotic program. Currently, there are over 1800 known apoptotic caspase substrates, many of them known regulators of cell proliferation and death
Externí odkaz:
https://doaj.org/article/81f8e2bbb99644b88f2c58c76f987951
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67952 (2013)
In a pulse-chase assay, the in vivo degradation of a protein is measured through a brief labeling of cells with, for example, a radioactive amino acid, followed by cessation of labeling and analysis of cell extracts prepared at different times afterw
Externí odkaz:
https://doaj.org/article/737efa385cf24535aba1d23bf4d27b77
Autor:
Vicky Appleman, Atsushi Matsuda, Michelle Ganno, Angel Maldonado Lopez, Emily Rosentrater, Camilla Christensen, Samantha Merrigan, Hong Myung Lee, Min Young Lee, Linlin Dong, Jian Huang, Natasha Iartchouk, Dong Mei Zhang, Jianing Wang, He Xu, Tomoki Yoneyama, Konstantin Piatkov, Carole Harbison, Adnan Abu-Yousif
Publikováno v:
Regular and Young Investigator Award Abstracts.
Bispecific T cell engager (TCE) is an emerging anti-cancer modality which redirects cytotoxic T cells to tumor cells expressing tumor-associated antigen (TAA) thereby forming immune synapses to exerts anti-tumor effects. Considering the protein engin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e117c595eb72df6ffe9f0ec522499b3a
https://doi.org/10.1101/2021.12.06.471352
https://doi.org/10.1101/2021.12.06.471352
Autor:
Nicole Bebrin, Linlin Dong, Mark G. Qian, Dong Wei, Shinji Iwasaki, Konstantin Piatkov, Kojo Abdul-Hadi
Publikováno v:
Analytical chemistry. 93(16)
In the immuno-oncology field, surrogate mouse monoclonal antibodies are often preferred in establishing proper PK/PD/efficacy correlations as well as supporting anticipated mouse to human translation. Thus, a highly sensitive and specific bioanalytic
Autor:
Konstantin Piatkov, Olga I. Kechko, Irina Yu. Petrushanko, Vladimir A. Mitkevich, Alexander A. Makarov
Publikováno v:
Alzheimer's & Dementia. 14
Publikováno v:
Journal of Structural Biology
Journal of Structural Biology, Elsevier, 2007, 159 (1), pp.154-157. ⟨10.1016/j.jsb.2007.02.005⟩
Journal of Structural Biology, Elsevier, 2007, 159 (1), pp.154-157. ⟨10.1016/j.jsb.2007.02.005⟩
Low affinity protein complexes are difficult to isolate and handle in crystallization experiments. Size-exclusion chromatography often does not allow purification of the homogeneous complex. Here we used a size-filtration approach for the purificatio