Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Konstantin G. Birukov"'
Autor:
Charles H. Williams, Leif R. Neitzel, Jessica Cornell, Samantha Rea, Ian Mills, Maya S. Silver, Jovanni D. Ahmad, Konstantin G. Birukov, Anna Birukova, Henry Brem, Betty Tyler, Eli E. Bar, Charles C. Hong
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-18 (2024)
Abstract Background Glioblastoma multiforme (GBM) stands as a formidable challenge in oncology because of its aggressive nature and severely limited treatment options. Despite decades of research, the survival rates for GBM remain effectively stagnan
Externí odkaz:
https://doaj.org/article/f7b2aed27b4f4e79988cd025a47bae74
Autor:
Rajesh Kushwaha, Yue Li, Natallia Makarava, Narayan P. Pandit, Kara Molesworth, Konstantin G. Birukov, Ilia V. Baskakov
Publikováno v:
Neurobiology of Disease, Vol 185, Iss , Pp 106264- (2023)
Background: Impairment of the blood-brain barrier (BBB) is considered to be a common feature among neurodegenerative diseases, including Alzheimer's, Parkinson's and prion diseases. In prion disease, increased BBB permeability was reported 40 years a
Externí odkaz:
https://doaj.org/article/079d1c33179b4a6ba4354959667fc461
Autor:
Jennifer H. Madenspacher, Eric D. Morrell, Jeffrey G. McDonald, Bonne M. Thompson, Yue Li, Konstantin G. Birukov, Anna A. Birukova, Renee D. Stapleton, Aidin Alejo, Peer W. Karmaus, Julie M. Meacham, Prashant Rai, Carmen Mikacenic, Mark M. Wurfel, Michael B. Fessler
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined. Recently, we reported that Ch25h is induced in monocyte-derived macrop
Externí odkaz:
https://doaj.org/article/1109a8bf1a3b4286b2173352ad418326
Autor:
Yunbo Ke, Pratap Karki, Yue Li, Kamoltip Promnares, Chen-Ou Zhang, Thomas L. Eggerman, Alexander V. Bocharov, Anna A. Birukova, Konstantin G. Birukov
Publikováno v:
Cells, Vol 12, Iss 15, p 1937 (2023)
Truncated phospholipid oxidation products (Tr-OxPL) increase in blood circulation with aging; however, their role in the severity of vascular dysfunction and bacterial lung injury in aging groups remains poorly understood. We investigated the effects
Externí odkaz:
https://doaj.org/article/e822ffd47cfd4fdca9f83025b7f4e4fe
Autor:
Yunbo Ke, Julie L. Proctor, Chenou Zhang, Juliana Medina, Catriona H. T. Miller, Junghyun Kim, Thomas E. Grissom, Anna A. Birukova, Gary M. Fiskum, Konstantin G. Birukov
Publikováno v:
Physiological Reports, Vol 10, Iss 13, Pp n/a-n/a (2022)
Abstract Traumatic brain injury (TBI) has been associated with the development of indirect acute respiratory distress syndrome (ARDS). However, the causative relationship between TBI and lung injury remains unclear. To explore potential mechanisms li
Externí odkaz:
https://doaj.org/article/b6508ddd9a50422ba4fbd28515c9547b
Autor:
Pratap Karki, Konstantin G. Birukov
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Earlier studies investigating the pathogenesis of chronic vascular inflammation associated with atherosclerosis described pro-inflammatory and vascular barrier disruptive effects of lipid oxidation products accumulated in the sites of vascular lesion
Externí odkaz:
https://doaj.org/article/5384cfc7956a408c813b4eb0d325d6bc
Autor:
Christina Mauerhofer, Taras Afonyushkin, Olga V. Oskolkova, Klara Hellauer, Bernd Gesslbauer, Jasmin Schmerda, Yunbo Ke, Andreas Zimmer, Anna A. Birukova, Konstantin G. Birukov, Valery Bochkov
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1741 (2022)
Oxidized phospholipids (OxPLs) are generated by enzymatic or autooxidation of esterified polyunsaturated fatty acids (PUFAs) residues. OxPLs are present in circulation and atherosclerotic plaques where they are thought to induce predominantly proinfl
Externí odkaz:
https://doaj.org/article/9f9c42961f1b4566b0ce29ef2828cc2e
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Extracellular histones released from injured or dying cells following trauma and other severe insults can act as potent damage-associated molecular patterns. In fact, elevated levels of histones are present in human circulation in hyperinflammatory s
Externí odkaz:
https://doaj.org/article/c6acc7fec2874391879cd2261dacd61e
Autor:
Pratap Karki, Konstantin G. Birukov
Publikováno v:
Cells, Vol 9, Iss 4, p 981 (2020)
Circulating and cell membrane phospholipids undergo oxidation caused by enzymatic and non-enzymatic mechanisms. As a result, a diverse group of bioactive oxidized phospholipids generated in these conditions have both beneficial and harmful effects on
Externí odkaz:
https://doaj.org/article/2b2a9536296d459c896ea9bace5513b4
Autor:
Konstantin G. Birukov, Pratap Karki
Publikováno v:
Pulmonary Circulation, Vol 8 (2018)
The lung endothelium is vulnerable to both exogenous and endogenous insults, so a properly coordinated efficient repair system is essential for the timely recovery of the lung after injury. The agents that cause endothelial injury and dysfunction fal
Externí odkaz:
https://doaj.org/article/cc58e9d8d94c4c8692f025d0ebca934f