Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Konstantin Aizikov"'
Autor:
Clifford G. Phaneuf, Konstantin Aizikov, Dmitry Grinfeld, Arne Kreutzmann, Daniel Mourad, Oliver Lange, Daniel Dai, Bailin Zhang, Alexei Belenky, Alexander A. Makarov, Alexander R. Ivanov
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Mass spectrometry-based thermal stability assays (MS-TSA) are a promising approach to characterize protein-ligand interaction, and several strategies have been recently developed to improve their performance. Here, the authors combine three recent st
Externí odkaz:
https://doaj.org/article/05496a164ec94f12bd49c4bcf4419555
Autor:
Evan Maxwell, Yan Tan, Yuxiang Tan, Han Hu, Gary Benson, Konstantin Aizikov, Shannon Conley, Gregory O Staples, Gordon W Slysz, Richard D Smith, Joseph Zaia
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45474 (2012)
Glycosylation modifies the physicochemical properties and protein binding functions of glycoconjugates. These modifications are biosynthesized in the endoplasmic reticulum and Golgi apparatus by a series of enzymatic transformations that are under co
Externí odkaz:
https://doaj.org/article/c2406ac9ac5e43c88a80e9605ae6479d
Autor:
Virginia K. James, James D. Sanders, Konstantin Aizikov, Kyle L. Fort, Dmitry Grinfeld, Alexander Makarov, Jennifer S. Brodbelt
Publikováno v:
Analytical Chemistry. 95:7656-7664
Autor:
Virginia K. James, James D. Sanders, Kyle L Fort, Konstantin Aizikov, Dmitry Grinfeld, Alexander Makarov, Jennifer S. Brodbelt
The measurement of collision cross sections (CCS) offers supplemental information about sizes and conformations of ions beyond mass analysis alone. We have previously shown that CCSs can be determined directly from the time-domain transient decay of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c71a82eec5abeafcd8a53de8d3fe3d8
https://doi.org/10.26434/chemrxiv-2022-xq73s-v2
https://doi.org/10.26434/chemrxiv-2022-xq73s-v2
Autor:
Runlong Cai, Wei Huang, Melissa Meder, Frederic Bourgain, Konstantin Aizikov, Matthieu Riva, Federico Bianchi, Mikael Ehn
Orbitrap Fourier transform mass spectrometry coupled with chemical ionization (CI) is a new-generation technique for online analysis in atmospheric chemistry. The advantage of the high resolving power of the CI-Orbitrap has been compromised by its re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284d1d7750cc5d33e486c5b35af2e789
http://hdl.handle.net/10138/352877
http://hdl.handle.net/10138/352877
Autor:
Virginia K. James, James D. Sanders, Konstantin Aizikov, Kyle L. Fort, Dmitry Grinfeld, Alexander Makarov, Jennifer S. Brodbelt
Publikováno v:
Analytical chemistry. 94(45)
Measurement of collision cross section (CCS), a parameter reflecting an ion's size and shape, alongside high-resolution mass analysis extends the depth of molecular analysis by providing structural information beyond molecular mass alone. Although th
Autor:
Cajetan Neubauer, Kyle L. Fort, Stanley J. Mroczkowski, Xingchen T. Wang, Andreas Hilkert, Konstantin Aizikov, John Karl Böhlke, Sebastian H. Kopf
Publikováno v:
Analytical chemistry. 93(26)
Widely used isotope ratio mass spectrometers have limited capabilities to measure metabolites, drugs, or small polyatomic ions without the loss of structural isotopic information. A new approach has recently been introduced that uses electrospray ion
Autor:
Tobias P Woerner, Albert J. R. Heck, Alexander Makarov, Kyle L. Fort, Joost Snijder, Konstantin Aizikov
To enhance the performance of charge detection mass spectrometry, we investigated the behavior of macromolecular single ions on their paths towards and within the Orbitrap analyzer. We discovered that ions in mass beyond one megadalton reach a platea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99dac4d308e41e229194c4965a31aae5
https://doi.org/10.1101/2021.06.15.448530
https://doi.org/10.1101/2021.06.15.448530
Autor:
Pavel A. Pevzner, Alain Beck, Yury O. Tsybin, Konstantin Aizikov, Luca Fornelli, Alexander Makarov, Daniel Ayoub, Xiaowen Liu, Eugen Damoc
Publikováno v:
Journal of Proteomics. 159:67-76
The increasing importance of immunoglobulins G (IgGs) as biotherapeutics calls for improved structural characterization methods designed for these large (similar to 150 kDa) macromolecules. Analysis workflows have to be rapid, robust, and require min
Autor:
Mikhail V. Gorshkov, Konstantin Aizikov, Daniel Ayoub, Kristina Srzentić, Konstantin O. Nagornov, Alain Beck, Yury O. Tsybin, Laure Menin, Anna A. Lobas, Natalia Gasilova, Anton N. Kozhinov, Luca Fornelli
Publikováno v:
Analytical chemistry. 90(21)
Pairing light and heavy chains in monoclonal antibodies (mAbs) using top-down (TD) or middle-down (MD) mass spectrometry (MS) may complement the sequence information on single chains provided by high-throughput genomic sequencing and bottom-up proteo