Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Konstantin A. Petrov"'
Publikováno v:
Molbank, Vol 2023, Iss 4, p M1739 (2023)
In this study, the synthesis and biological activities of previously and newly synthesized oleanolic acid derivatives containing seven-membered cyclic amines at the C28 position were described. The obtained compounds were fully characterized via 1H a
Externí odkaz:
https://doaj.org/article/6b8f8cc32f0b459eb73a7d2cdbc015a0
Autor:
Irina V. Zueva, Elmira A. Vasilieva, Gulnara A. Gaynanova, Andrey V. Moiseenko, Anna D. Burtseva, Konstantin M. Boyko, Lucia Ya. Zakharova, Konstantin A. Petrov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16395 (2023)
A central event in the pathogenesis of Alzheimer’s disease (AD) is the accumulation of senile plaques composed of aggregated amyloid-β (Aβ) peptides. The main class of drugs currently used for the treatment of AD are the acetylcholinesterase (ACh
Externí odkaz:
https://doaj.org/article/914bb288248b44059fcaee84f530589e
Autor:
Boris I. Gorin, Elena A. Tukhovskaya, Alina M. Ismailova, Gulsara A. Slashcheva, Oksana A. Lenina, Konstantin A. Petrov, Ilya V. Kazeev, Arkady N. Murashev
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Pharmacokinetic characteristics as well as cognitive-enhancing nootropic activity of latrepirdine (Dimebon®) in relationship with its polymorphic forms have been studied in SD and Wistar rats.Methods: The pharmacokinetics of six polymo
Externí odkaz:
https://doaj.org/article/1d87c4fd780e4f40b0d93ab37ac675e8
Autor:
Oksana A. Lenina, Konstantin A. Petrov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Organophosphorus (OP) compounds that inhibit acetylcholinesterase are a common cause of poisoning worldwide, resulting in several hundred thousand deaths each year. The pathways activated during OP compound poisoning via overstimulation of m
Externí odkaz:
https://doaj.org/article/10a38c14411146edbb56b22dbe47f7b5
Autor:
Rustem R. Zairov, Alexey P. Dovzhenko, Anastasiia S. Sapunova, Alexandra D. Voloshina, Kirill A. Sarkanich, Amina G. Daminova, Irek R. Nizameev, Dmitry V. Lapaev, Svetlana N. Sudakova, Sergey N. Podyachev, Konstantin A. Petrov, Alberto Vomiero, Asiya R. Mustafina
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The work introduces hydrophilic PSS-[Tb2(TCAn)2] nanoparticles to be applied as highly sensitive intracellular temperature nanosensors. The nanoparticles are synthesized by solvent-induced nanoprecipitation of [Tb2(TCAn)2] complexes (TCAn -
Externí odkaz:
https://doaj.org/article/1ae0059bbe1f4b10b3d99b68176735a3
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
The neuromuscular junction (NMJ) is a tripartite synapse in which not only presynaptic and post-synaptic cells participate in synaptic transmission, but also terminal Schwann cells (TSC). Acetylcholine (ACh) is the neurotransmitter that mediates the
Externí odkaz:
https://doaj.org/article/a4ed20d53b564ba7898ded9fa3f6ba90
Autor:
Elmira A. Vasilieva, Darya A. Kuznetsova, Farida G. Valeeva, Denis M. Kuznetsov, Andrey V. Zakharov, Syumbelya K. Amerhanova, Alexandra D. Voloshina, Irina V. Zueva, Konstantin A. Petrov, Lucia Ya. Zakharova
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2846 (2022)
Chitosan-decorated liposomes were proposed for the first time for the intranasal delivery of acetylcholinesterase (AChE) reactivator pralidoxime chloride (2-PAM) to the brain as a therapy for organophosphorus compounds (OPs) poisoning. Firstly, the c
Externí odkaz:
https://doaj.org/article/2e56ae732e4c47d3ab25d3ee9aaa2469
Autor:
Vyacheslav E. Semenov, Irina V. Zueva, Sofya V. Lushchekina, Eduard G. Suleimanov, Liliya M. Gubaidullina, Marina M. Shulaeva, Oksana A. Lenina, Konstantin A. Petrov
Publikováno v:
Molecules, Vol 27, Iss 22, p 7855 (2022)
Novel derivatives based on 6-methyluracil and condensed uracil, 2,4-quinazoline-2,4-dione, were synthesized with terminal meta- and para-benzoate moieties in polymethylene chains at the N atoms of the pyrimidine ring. In the synthesized compounds, th
Externí odkaz:
https://doaj.org/article/76c4a99ab68949beb4f66f6db588bdb1
Autor:
Darya A. Kuznetsova, Gulnara A. Gaynanova, Elmira A. Vasilieva, Rais V. Pavlov, Irina V. Zueva, Vasily M. Babaev, Denis M. Kuznetsov, Alexandra D. Voloshina, Konstantin A. Petrov, Lucia Y. Zakharova, Oleg G. Sinyashin
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1950 (2022)
One of the main problems in the treatment of poisoning with organophosphorus (OPs) inhibitors of acetylcholinesterase (AChE) is low ability of existing reactivators of AChE that are used as antidotes to cross the blood-brain barrier (BBB). In this wo
Externí odkaz:
https://doaj.org/article/6c996d8128644c55a66f165b214b4bef
Autor:
Vyacheslav E. Semenov, Irina V. Zueva, Marat A. Mukhamedyarov, Sofya V. Lushchekina, Elena O. Petukhova, Lilya M. Gubaidullina, Evgeniya S. Krylova, Lilya F. Saifina, Oksana A. Lenina, Konstantin A. Petrov
Publikováno v:
Molecules, Vol 25, Iss 18, p 4191 (2020)
In this study, novel derivatives based on 6-methyluracil and condensed uracil were synthesized, namely, 2,4-quinazoline-2,4-dione with ω-(ortho-nitrilebenzylethylamino) alkyl chains at the N atoms of the pyrimidine ring. In this series of synthesize
Externí odkaz:
https://doaj.org/article/22eb92d6ea8f4ca9a41b28c7829467bb