Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Konstantin Levitsky"'
Autor:
Ravi Vij, Kyriakos P. Papadopoulos, Alvin F. Wong, Lois Kellerman, Francesco Parlati, Susan Lee, Sundar Jagannath, Gregory J. Ahmann, Ashraf Badros, Michael Wang, Christopher J. Kirk, Mark K. Bennett, Shirin Arastu-Kapur, Konstantin Levitsky, David S. Siegel, Tina F. Woo, Ruben Niesvizky
Publikováno v:
British Journal of Haematology
Summary While proteasome inhibition is a validated therapeutic approach for multiple myeloma (MM), inhibition of individual constitutive proteasome (c20S) and immunoproteasome (i20S) subunits has not been fully explored owing to a lack of effective t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009ff50e0186a1ca8b1123977804ad30
https://doi.org/10.1111/bjh.14014
https://doi.org/10.1111/bjh.14014
Autor:
Monette Aujay, Paulina Ruurs, Francesco Parlati, James B. Lorens, Kevin D. Shenk, Catherine Sylvain, Konstantin Levitsky, Susan Lee, Mark K. Bennett, Erika Suzuki, Yan Lu, David Micklem
Publikováno v:
Blood. 114:3439-3447
Carfilzomib is a proteasome inhibitor in clinical development that primarily targets the chymotrypsin-like (CT-L) subunits in both the constitutive proteasome (c20S) and the immunoproteasome (i20S). To investigate the impact of inhibiting the CT-L ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ca9ed17b5043a196fa0ecbd344bb7a
https://doi.org/10.1182/blood-2009-05-223677
https://doi.org/10.1182/blood-2009-05-223677
Publikováno v:
ChemBioChem. 6:890-899
Investigations on the scope and utility of exo-mechanism proximity-accelerated reactions in engineered receptor-ligand systems are reported. We synthesized a series of electrophilic cyclosporin (CsA) derivatives by varying electrophiles and linker le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8353064105d494310eb10885263e04
https://doi.org/10.1002/cbic.200400383
https://doi.org/10.1002/cbic.200400383
Publikováno v:
Human gene therapy. 19(11)
Widespread adaptation of small molecule-regulated expression systems requires the development of selective inducer molecules that do not have any significant side effects on the endogenous receptors from which the regulated expression system is deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928973a0ccfce2e6c71879a7d06381fb
https://pubmed.ncbi.nlm.nih.gov/19000019
https://pubmed.ncbi.nlm.nih.gov/19000019
Publikováno v:
Organic letters. 5(5)
A new approach for creating allele-specific inhibitors is demonstrated. In this approach, a receptor and ligand are engineered to contain complementary reactive groups that form a covalent bond via a proximity-accelerated reaction upon formation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d396d7d49a64cab4fa7b88ac484b4d
https://pubmed.ncbi.nlm.nih.gov/12605492
https://pubmed.ncbi.nlm.nih.gov/12605492
Autor:
Konstantin Levitsky, Paul Szymanski, Fang Jin, Janet Meuer-Ogden, Peter Droescher, Rick Harkins
Publikováno v:
Human Gene Therapy. :081015093227032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd2b6c807fedfface781b95ae5ae1461
https://doi.org/10.1089/hgt.2008.082
https://doi.org/10.1089/hgt.2008.082
Publikováno v:
ChemBioChem; May2005, Vol. 6 Issue 5, p890-899, 10p