Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Konstantin, Khrapko"'
Autor:
Victor Shamanskiy, Alina A. Mikhailova, Evgenii O. Tretiakov, Kristina Ushakova, Alina G. Mikhailova, Sergei Oreshkov, Dmitry A. Knorre, Natalia Ree, Jonathan B. Overdevest, Samuel W. Lukowski, Irina Gostimskaya, Valerian Yurov, Chia-Wei Liou, Tsu-Kung Lin, Wolfram S. Kunz, Alexandre Reymond, Ilya Mazunin, Georgii A. Bazykin, Jacques Fellay, Masashi Tanaka, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, but this alone does no
Externí odkaz:
https://doaj.org/article/4165b20a8937424aafa2ba2a950a3360
Publikováno v:
eLife, Vol 12 (2023)
A large-scale study of mutations in mitochondrial DNA has revealed a subset that do not accumulate with age.
Externí odkaz:
https://doaj.org/article/dae47a2051194391add1ee2a17f4da36
Autor:
Robert Logan, Zoe Fleischmann, Sofia Annis, Amy Wangsness Wehe, Jonathan L. Tilly, Dori C. Woods, Konstantin Khrapko
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background Third-generation sequencing offers some advantages over next-generation sequencing predecessors, but with the caveat of harboring a much higher error rate. Clustering-related sequences is an essential task in modern biology. To ac
Externí odkaz:
https://doaj.org/article/30ff4bd2fcb74a6aafbb02ea207905cd
Autor:
Konstantin Gunbin, Leonid Peshkin, Konstantin Popadin, Sofia Annis, Rebecca R. Ackermann, Konstantin Khrapko
Publikováno v:
Data in Brief, Vol 13, Iss , Pp 536-544 (2017)
The data and methods presented in this article are supplementing the research article ''Integration of mtDNA pseudogenes into the nuclear genome coincides with speciation of the human genus. A hypothesis'', DOI: 10.1016/j.mito.2016.12.001 (Gunbin et
Externí odkaz:
https://doaj.org/article/c220cc40b37644789d17081b4c500900
Autor:
Konstantin Khrapko, Zoe Fleischmann, Maxim Braverman, Markuzon N, Jonathan L. Tilly, Douglass M. Turnbull, Sarah J Pickett, David Stein, Dori C. Woods, Konstantin Popadin, Mark Khrapko, D. Aidlen, Melissa Franco
Publikováno v:
Human Molecular Genetics. 31:4075-4086
The A-to-G point mutation at position 3243 in the human mitochondrial genome (m.3243A > G) is the most common pathogenic mtDNA variant responsible for disease in humans. It is widely accepted that m.3243A > G levels decrease in blood with age, and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a839a2f5c569df08360250b0e656a392
https://doi.org/10.1093/hmg/ddac149
https://doi.org/10.1093/hmg/ddac149
Autor:
Auden Cote-L’Heureu, Melissa Franco, Yogesh N. K. Maithania, Konstantin Popadin, Dori Woods, Jonathan Tilly, Konstantin Khrapko
Every cell in our body contains a vibrant population of mitochondria, or, more precisely, of mitochondrial DNA molecules (mtDNAs). Just like members of any population mtDNAs multiply (by replication) and ‘die’ (i.e., are removed, either by degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1495144bf983fd14e0b60ade1e1f0bf7
https://doi.org/10.1101/2023.04.14.536897
https://doi.org/10.1101/2023.04.14.536897
Autor:
Adeel Safdar, Konstantin Khrapko, James M. Flynn, Ayesha Saleem, Michael De Lisio, Adam P. W. Johnston, Yevgenya Kratysberg, Imtiaz A. Samjoo, Yu Kitaoka, Daniel I. Ogborn, Jonathan P. Little, Sandeep Raha, Gianni Parise, Mahmood Akhtar, Bart P. Hettinga, Glenn C. Rowe, Zoltan Arany, Tomas A. Prolla, Mark A. Tarnopolsky
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/e0ddedd4abac41088e921afb2a13b202
Autor:
Zoë Fleischmann, Auden Cote-L’Heureux, Melissa Franco, Sergey Oreshkov, Sofia Annis, Mark Khrapko, Dylan Aidlen, Konstantin Popadin, Dori C. Woods, Jonathan L. Tilly, Konstantin Khrapko
The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c177685e6fd9f1df3ef5da36f93ea208
https://doi.org/10.1101/2022.12.12.520138
https://doi.org/10.1101/2022.12.12.520138
Autor:
Maxim Ri, Natalia Ree, Sergey Oreshkov, Maria Tofilo, Irina Zvereva, Anastasia Kirillova, Konstantin Gunbin, Valerian Yurov, Andres Salumets, Dori C. Woods, Konstantin Khrapko, Jacques Fellay, Jonathan L. Tilly, Ilya Mazunin, Konstantin Popadin
Using low-coverage, whole-genome sequences of trophectoderm biopsies from 11,610 human blastocyst-stage embryos, we analyzed the relationship between chromosomal abnormalities and mitochondrial (mt) DNA dynamics. Comparing 6,208 aneuploid and 5,402 e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06078716fd9dfebefb7dc4884c8ca45
https://doi.org/10.1101/2022.10.14.512116
https://doi.org/10.1101/2022.10.14.512116