Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Konstantin, Khodosevich"'
Autor:
Signe Schmidt Kjølner Hansen, Robert Krautz, Daria Rago, Jesper Havelund, Arnaud Stigliani, Nils J. Færgeman, Audrey Prézelin, Julie Rivière, Anne Couturier-Tarrade, Vyacheslav Akimov, Blagoy Blagoev, Betina Elfving, Ditte Neess, Ulla Vogel, Konstantin Khodosevich, Karin Sørig Hougaard, Albin Sandelin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lu
Externí odkaz:
https://doaj.org/article/f27ea51dbf684c569e6842c66b46c497
Autor:
Mark J. Luinenburg, Mirte Scheper, Frederik N. F. Sørensen, Jasper J. Anink, Wim Van Hecke, Irina Korshunova, Floor E. Jansen, Kate Riney, Pieter van Eijsden, Peter Gosselaar, James D. Mills, Rozemarijn S. Kalf, Till S. Zimmer, Diede W. M. Broekaart, Konstantin Khodosevich, Eleonora Aronica, Angelika Mühlebner
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionConstitutive activation of the mTOR pathway, as observed in Tuberous Sclerosis Complex (TSC), leads to glial dysfunction and subsequent epileptogenesis. Although astrocytes are considered important mediators for synaptic clearance and pha
Externí odkaz:
https://doaj.org/article/0db49681f11748d091f2555b467a7b86
Autor:
Valeriia Gulaia, Mikhail Shmelev, Aleksander Romanishin, Nikita Shved, Vladislav Farniev, Nikolay Goncharov, Arthur Biktimirov, Irene Lisa Vargas, Konstantin Khodosevich, Alexander Kagansky, Vadim Kumeiko
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Glioma is a devastating brain tumor with a high mortality rate attributed to the glioma stem cells (GSCs) possessing high plasticity. Marker mutations in isocitrate dehydrogenase type 1 (IDH1) and tumor protein 53 (TP53) are frequent in glio
Externí odkaz:
https://doaj.org/article/597fc3f1fea54ecf87e944d78dfd3904
Autor:
Katharina Theresa Kohler, Nadine Goldhammer, Samuel Demharter, Ulrich Pfisterer, Konstantin Khodosevich, Lone Rønnov-Jessen, Ole William Petersen, René Villadsen, Jiyoung Kim
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Normal breast luminal epithelial progenitors have been implicated as cell of origin in basal-like breast cancer, but their anatomical localization remains understudied. Here, we combine collection under the microscope of organoids from reduc
Externí odkaz:
https://doaj.org/article/25f5e72897134d6d84063e55bb32573e
Autor:
Burcu A. Pazarlar, Sanjay S. Aripaka, Viktor Petukhov, Lars Pinborg, Konstantin Khodosevich, Jens D. Mikkelsen
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-10 (2022)
Abstract Synaptic vesicle glycoprotein-2 (SV2) is a family of proteins consisting of SV2A, SV2B, and SV2C. This protein family has attracted attention in recent years after SV2A was shown to be an epileptic drug target and a perhaps a biomarker of sy
Externí odkaz:
https://doaj.org/article/9ca4e0bee90e442c8e3349b0385ee878
Autor:
Tobias Bergmann, Yong Liu, Jonathan Skov, Leo Mogus, Julie Lee, Ulrich Pfisterer, Louis-Francois Handfield, Andrea Asenjo-Martinez, Irene Lisa-Vargas, Stefan E. Seemann, Jimmy Tsz Hang Lee, Nikolaos Patikas, Birgitte Rahbek Kornum, Mark Denham, Poul Hyttel, Menno P. Witter, Jan Gorodkin, Tune H. Pers, Martin Hemberg, Konstantin Khodosevich, Vanessa Jane Hall
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Stellate cells are principal neurons in the entorhinal cortex that contribute to spatial processing. They also play a role in the context of Alzheimer’s disease as they accumulate Amyloid beta early in the disease. Producing human stellate cells fr
Externí odkaz:
https://doaj.org/article/33496e16dde243a0a9478f786050d0ba
Autor:
Valeriia Gulaia, Mikhail Shmelev, Aleksander Romanishin, Nikita Shved, Vladislav Farniev, Nikolay Goncharov, Arthur Biktimirov, Irene Lisa Vargas, Konstantin Khodosevich, Alexander Kagansky, Vadim Kumeiko
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/14833ec726ee44d6a84b09518b9f4714
Autor:
Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo-Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, pred
Externí odkaz:
https://doaj.org/article/3e192b5fa2834006a330d7be93363fc6
Autor:
Yong Liu, Tobias Bergmann, Yuki Mori, Juan Miguel Peralvo Vidal, Maria Pihl, Navneet A. Vasistha, Preben Dybdahl Thomsen, Stefan E. Seemann, Jan Gorodkin, Poul Hyttel, Konstantin Khodosevich, Menno P. Witter, Vanessa Jane Hall
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
The entorhinal cortex (EC) is the spatial processing center of the brain and structurally is an interface between the three layered paleocortex and six layered neocortex, known as the periarchicortex. Limited studies indicate peculiarities in the for
Externí odkaz:
https://doaj.org/article/746fcf2ebe194ca39fff7002aae87ad9
Autor:
Masakazu Umezawa, Atsuto Onoda, Irina Korshunova, Alexander C. Ø. Jensen, Ismo K. Koponen, Keld A. Jensen, Konstantin Khodosevich, Ulla Vogel, Karin S. Hougaard
Publikováno v:
Particle and Fibre Toxicology, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background Engineered nanoparticles are smaller than 100 nm and designed to improve or creating even new physico-chemical properties. Consequently, toxicological properties of materials may change as size reaches the nm size-range. We examin
Externí odkaz:
https://doaj.org/article/4bfd3095277642c6a8e11aa3924ef07f