Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.

Autor: Robbins DW; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Noviski MA; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Tan YS; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Konst ZA; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Kelly A; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Auger P; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Brathaban N; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Cass R; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Chan ML; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Cherala G; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Clifton MC; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Gajewski S; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Ingallinera TG; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Karr D; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Kato D; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Ma J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., McKinnell J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., McIntosh J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Mihalic J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Murphy B; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Panga JR; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Peng G; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Powers J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Perez L; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Rountree R; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Tenn-McClellan A; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Sands AT; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Weiss DR; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Wu J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Ye J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Guiducci C; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Hansen G; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States., Cohen F; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2321-2336. Date of Electronic Publication: 2024 Feb 01.

A practical method for regiocontrolled one-carbon ring contraction.

Autor: Mitcheltree MJ; Department of Chemistry, Yale University, New Haven, CT 06511, United States., Konst ZA; Department of Chemistry, Yale University, New Haven, CT 06511, United States., Herzon SB; Department of Chemistry, Yale University, New Haven, CT 06511, United States.

Publikováno v: Tetrahedron letters [Tetrahedron Lett] 2013 Jul 08; Vol. 69 (27-28), pp. 5634-5639. Date of Electronic Publication: 2013 Apr 17.