A microbial supply chain for production of the anti-cancer drug vinblastine

Autor: Jie Zhang, Lea G. Hansen, Olga Gudich, Konrad Viehrig, Lærke M. M. Lassen, Lars Schrübbers, Khem B. Adhikari, Paulina Rubaszka, Elena Carrasquer-Alvarez, Ling Chen, Vasil D’Ambrosio, Beata Lehka, Ahmad K. Haidar, Saranya Nallapareddy, Konstantina Giannakou, Marcos Laloux, Dushica Arsovska, Marcus A. K. Jørgensen, Leanne Jade G. Chan, Mette Kristensen, Hanne B. Christensen, Suresh Sudarsan, Emily A. Stander, Edward Baidoo, Christopher J. Petzold, Tune Wulff, Sarah E. O’Connor, Vincent Courdavault, Michael K. Jensen, Jay D. Keasling

Publikováno v: Nature
Zhang, J, Hansen, L G, Gudich, O, Viehrig, K, Lassen, L M M, Schrübbers, L, Adhikari, K B, Rubaszka, P, Carrasquer-Alvarez, E, Chen, L, D’Ambrosio, V, Lehka, B, Haidar, A K, Nallapareddy, S, Giannakou, K, Laloux, M, Arsovska, D, Jørgensen, M A K, Chan, L J G, Kristensen, M, Christensen, H B, Sudarsan, S, Stander, E A, Baidoo, E, Petzold, C J, Wulff, T, O’Connor, S E, Courdavault, V, Jensen, M K & Keasling, J D 2022, ' A microbial supply chain for production of the anti-cancer drug vinblastine ', Nature, vol. 609, no. 7926, pp. 341-347 . https://doi.org/10.1038/s41586-022-05157-3
Nature, vol 609, iss 7926

Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine1. As MIAs are difficult to chemically synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bacac052957ae55ba7af120ea83ec4
https://pubmed.ncbi.nlm.nih.gov/36370691

Chemische Struktur und Biosynthese der Crocagine, polycyclischer Peptide ribosomalen Ursprungs ausChondromyces crocatus

Autor: Dirk Trauner, Carsten Volz, Jennifer Herrmann, Jesko Köhnke, Frank Surup, Sebastian Adam, Konrad Viehrig, Rolf Müller, Antoine Abou Fayad

Publikováno v: Angewandte Chemie. 129:7513-7517

Sekundarmetabolom-Analysen in dem myxobakteriellen Naturstoffproduzenten Chondromyces crocatus Cm c5 fuhrten zur Isolierung und Charakterisierung der Crocagine, neuartiger polycyclischer Peptide mit Tetrahydropyrrolo[2,3-b]indol-Grundgerust. Der zuge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50fc91672888f0213551500d8f8d0107
https://doi.org/10.1002/ange.201612640

Structure and Biosynthesis of Crocagins: Polycyclic Posttranslationally Modified Ribosomal Peptides from Chondromyces crocatus

Autor: Rolf Müller, Antoine Abou Fayad, Frank Surup, Sebastian Adam, Jennifer Herrmann, Dirk Trauner, Jesko Köhnke, Carsten Volz, Konrad Viehrig

Publikováno v: Angewandte Chemie (International ed. in English). 56(26)

Secondary metabolome mining efforts in the myxobacterial multiproducer of natural products, Chondromyces crocatus Cm c5, resulted in the isolation and structure elucidation of crocagins, which are novel polycyclic peptides containing a tetrahydropyrr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffbd9842b1e0c3c7e110f15a8f5daa4
https://pubmed.ncbi.nlm.nih.gov/28544148

Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant staphylococci

Autor: Jennifer Herrmann, Konrad Viehrig, Rolf Jansen, Frank Surup, Rolf Müller, Kathrin I. Mohr

Publikováno v: Angewandte Chemie (International ed. in English). 53(49)

Two macrolide glycosides with a unique scaffold were isolated from cultures of the myxobacterium Pyxidicoc- cus fallax. Their structures, including absolute configurations, were elucidated by a combination of NMR, MS, degradation, and molecular model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af11d5521d8aa22a84daefe3e5f2d6a6
https://pubmed.ncbi.nlm.nih.gov/25294799

Jahnellamides, α-keto-β-methionine-containing peptides from the terrestrial myxobacterium Jahnella sp.: structure and biosynthesis

Autor: Konrad Viehrig, Ronald Garcia, Alberto Plaza, Rolf Müller

Publikováno v: Organic letters. 15(22)

Two new cyclic peptides, termed jahnellamides A and B, were isolated from the myxobacterium Jahnella sp. Their structures were solved by NMR, ESIMS, and chemical derivatizations. Jahnellamides are a new class of α-ketoamide-containing peptides compr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f5c16fc7846deaf76f899f9ae004f5
https://pubmed.ncbi.nlm.nih.gov/24199909