Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Konrad Talbot"'
Autor:
Noor Abdulhameed, Alice Babin, Kim Hansen, Riley Weaver, William A. Banks, Konrad Talbot, Elizabeth M. Rhea
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Targeting brain insulin resistance (BIR) has become an attractive alternative to traditional therapeutic treatments for Alzheimer’s disease (AD). Incretin receptor agonists (IRAs), targeting either or both of the glucagon-like peptide 1 (G
Externí odkaz:
https://doaj.org/article/07abfaa0874845af9bcb413f181b29c4
Autor:
Jennifer Larimore, Pearl V Ryder, Kun-Yong Kim, L Alex Ambrose, Christopher Chapleau, Gaston Calfa, Christina Gross, Gary J Bassell, Lucas Pozzo-Miller, Yoland Smith, Konrad Talbot, In-Hyun Park, Victor Faundez
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65069 (2013)
Clinical, epidemiological, and genetic evidence suggest overlapping pathogenic mechanisms between autism spectrum disorder (ASD) and schizophrenia. We tested this hypothesis by asking if mutations in the ASD gene MECP2 which cause Rett syndrome affec
Externí odkaz:
https://doaj.org/article/e5e9c45d4bc141f79c492ef9d2530021
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e16886 (2011)
An increasing number of studies report associations between variation in DTNBP1, a top candidate gene in schizophrenia, and both the clinical symptoms of the disorder and its cognitive deficits. DTNBP1 encodes dysbindin-1, reduced levels of which hav
Externí odkaz:
https://doaj.org/article/6f864d4ab39944b4b108ecb750cc6465
Publikováno v:
Biochem Pharmacol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817a9bce6328ce52ae56c64da3abce1c
https://europepmc.org/articles/PMC10108898/
https://europepmc.org/articles/PMC10108898/
Autor:
Nasim Sheikh-Bahaei, Konrad Talbot, Lon S. Schneider, Victoria Solomon, Helena C. Chui, Hussein N. Yassine, Meredith N. Braskie, Angad Thakral
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's Association. 18(3)
Medications for type 2 diabetes (T2DM) offer a promising path for discovery and development of effective interventions for dementia syndromes. A common feature of dementia syndromes is an energy failure due to reduced energy supply to neurons and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe70c2787b5f6b96d3e1e69be189abd8
https://pubmed.ncbi.nlm.nih.gov/34647685
https://pubmed.ncbi.nlm.nih.gov/34647685
Autor:
Hoau-Yan Wang, Konrad Talbot
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a3ac9f442325b769699ae3f763698e8
https://doi.org/10.1002/alz.039514
https://doi.org/10.1002/alz.039514
Autor:
Gary E. Fraser, Penelope J. Duerksen-Hughes, Michael J. Orlich, Fayth L. Miles, Konrad Talbot, John H. Zhang, Prativa Sherchan
Publikováno v:
Transl Stroke Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd1ec28de716f1e253fab20b4361e01
https://europepmc.org/articles/PMC8020833/
https://europepmc.org/articles/PMC8020833/
Autor:
Amanda Dobbyn, Laura M. Huckins, James Boocock, Laura G. Sloofman, Benjamin S. Glicksberg, Claudia Giambartolomei, Gabriel E. Hoffman, Thanneer M. Perumal, Kiran Girdhar, Yan Jiang, Towfique Raj, Douglas M. Ruderfer, Robin S. Kramer, Dalila Pinto, Schahram Akbarian, Panos Roussos, Enrico Domenici, Bernie Devlin, Pamela Sklar, Eli A. Stahl, Solveig K. Sieberts, Joseph Buxbaum, David Lewis, Raquel Gur, Chang-Gyu Hahn, Keisuke Hirai, Hiroyoshi Toyoshiba, Laurent Essioux, Lara Mangravite, Mette Peters, Thomas Lehner, Barbara Lipska, A. Ercument Cicek, Cong Lu, Kathryn Roeder, Lu Xie, Konrad Talbot, Scott E. Hemby, Andrew Browne, Andrew Chess, Aaron Topol, Alexander Charney, Ben Readhead, Bin Zhang, David A. Bennett, David H. Kavanagh, Eric E. Schadt, Hardik R. Shah, Jun Zhu, Jessica S. Johnson, John F. Fullard, Joel T. Dudley, Kristen J. Brennand, Menachem Fromer, Milind C. Mahajan, Shaun M. Purcell, Tymor Hamamsy, Vahram Haroutunian, Ying-Chih Wang, Zeynep H. Gümüş, Geetha Senthil, Robin Kramer, Benjamin A. Logsdon, Jonathan M.J. Derry, Kristen K. Dang, Roberto Visintainer, Leslie A. Shinobu, Patrick F. Sullivan, Lambertus L. Klei
Publikováno v:
American Journal of Human Genetics
Causal genes and variants within genome-wide association study (GWAS) loci can be identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and determining which variants underlie both GWAS and eQTL signals. Most analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2195e247d6f51da5e445339e007da95
https://doi.org/10.1016/j.ajhg.2018.04.011
https://doi.org/10.1016/j.ajhg.2018.04.011
Publikováno v:
Journal of the Neurological Sciences. 388:97-102
Objectives To examine the relationship between homeostatic model of insulin resistance (HOMA-IR) and cognitive test performance among population ≥ 60 years in a national database. Hypothesis Higher insulin resistance is associated with lower cognit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303befc088955895f0b644ce0c3d1e84
https://doi.org/10.1016/j.jns.2017.11.031
https://doi.org/10.1016/j.jns.2017.11.031
Autor:
Yun Wang, Nigel H. Greig, Yazhou Li, Konrad Talbot, Miaad Bader, Seong-Jin Yu, Chaim G. Pick, Richard D. DiMarchi, Ian A. Tamargo
Publikováno v:
Experimental Neurology. 288:176-186
Several single incretin receptor agonists that are approved for the treatment of type 2 diabetes mellitus (T2DM) have been shown to be neuroprotective in cell and animal models of neurodegeneration. Recently, a synthetic dual incretin receptor agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd407a24dd2eecc4b0f64054b2d2d337
https://doi.org/10.1016/j.expneurol.2016.11.005
https://doi.org/10.1016/j.expneurol.2016.11.005