Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Konrad T Sawicki"'
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 7 (2024)
Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including t
Externí odkaz:
https://doaj.org/article/31964fd61b794b31bbdd2edeab37b4e5
Autor:
Konrad T. Sawicki, Hongyan Ning, Norrina B. Allen, Mercedes R. Carnethon, Amisha Wallia, James D. Otvos, Issam Ben-Sahra, Elizabeth M. McNally, Janet K. Snell-Bergeon, John T. Wilkins
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
BACKGROUND Elevated circulating branched chain amino acids (BCAAs), measured at a single time point in middle life, are strongly associated with an increased risk of developing type 2 diabetes mellitus (DM). However, the longitudinal patterns of chan
Externí odkaz:
https://doaj.org/article/779ab5635c88401293a683894932f4f4
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102064- (2023)
Summary: Impaired mitochondrial iron metabolism is associated with aging and a variety of diseases, and there is a growing need to accurately quantify mitochondrial iron levels. This protocol provides an optimized method for evaluating non-heme and h
Externí odkaz:
https://doaj.org/article/81e1c7f5b98b446aa9e1bbfe57baef27
Autor:
Hsiang-Chun Chang, Jason Solomon Shapiro, Xinghang Jiang, Grant Senyei, Teruki Sato, Justin Geier, Konrad T Sawicki, Hossein Ardehali
Publikováno v:
eLife, Vol 10 (2021)
Chronic loss of Augmenter of Liver Regeneration (ALR) results in mitochondrial myopathy with cataracts; however, the mechanism for this disorder remains unclear. Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein im
Externí odkaz:
https://doaj.org/article/09ea966f91184bedb8ce060eab6be3c0
Autor:
Konrad T Sawicki, Hongyan Ning, Keenan Fine, James D Otvos, Mercedes R Carnethon, Ravi V Shah, Venkatesh L Murthy, John T Wilkins
Publikováno v:
Circulation. 147
Introduction: Circulating branched chain amino acid (BCAA) levels are associated with the development of diabetes mellitus (DM) and downstream ASCVD in middle-aged women. It is unknown if BCAAs in young adult men and women are associated with ASCVD e
Autor:
John T Wilkins, Waleed Alruwaili, Hongyan Ning, Konrad T Sawicki, Allan D Sniderman, James D Otvos, David R Jacobs, Venkatesh L Murthy, Ravi V Shah, Anand Rohatgi, Norrina B Allen
Publikováno v:
Circulation. 147
Introduction: HDL particles vary in size and concentration. Indices of overall HDL particle concentration (HDL-P) and the concentrations of different HDL size subspecies (small: H1-H3, medium: H4, H5, and large: H6, H7) have differential associations
Autor:
John T Wilkins, Hongyan Ning, Konrad Sawicki, Konrad T Sawicki, Allan D Sniderman, James D Otvos, Jamal S Rana, Venkatesh Murthy, Venkatesh L Murthy, Ravi V Shah, Norrina B Allen, Donald Lloyd-Jones
Publikováno v:
Circulation. 147
Introduction: Measures of atherogenic particle number (apoB and LDL particle number [LDL-P]) are stronger predictors of atherosclerotic cardiovascular disease (ASCVD) risk than measures of cholesterol concentration (LDL-C, non-HDL-C, total cholestero
Autor:
Konrad T. Sawicki, Hossein Ardehali
Publikováno v:
Nat Cardiovasc Res
Iron is essential to the production of myocardial energy and proteins critical for cardiovascular function. Nearly 50% of patients with heart failure with reduced ejection fraction (HFrEF) meet current criteria for iron deficiency, and there has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647fedc903790c47f0b88b5992a687ef
https://europepmc.org/articles/PMC9850675/
https://europepmc.org/articles/PMC9850675/
Publikováno v:
Circ Cardiovasc Imaging
Autor:
Julie A Fischer, Tanner O Monroe, Lorenzo L Pesce, Konrad T Sawicki, Mattia Quattrocelli, Rosemary Bauer, Samuel D Kearns, Matthew J Wolf, Megan J Puckelwartz, Elizabeth M McNally
Publikováno v:
Human molecular genetics.
Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a