Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Konrad M. Ricke"'
Autor:
Jean-Louis A. Parmasad, Konrad M. Ricke, Benjamin Nguyen, Morgan G. Stykel, Brodie Buchner-Duby, Amanda Bruce, Haley M. Geertsma, Eric Lian, Nathalie A. Lengacher, Steve M. Callaghan, Alvin Joselin, Julianna J. Tomlinson, Michael G. Schlossmacher, William L. Stanford, Jiyan Ma, Patrik Brundin, Scott D. Ryan, Maxime W. C. Rousseaux
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-13 (2024)
Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, no treatment can slow nor hal
Externí odkaz:
https://doaj.org/article/3314777d4067426182b748c43099f849
Autor:
Li Zhang, Zhaohong Qin, Konrad M. Ricke, Shelly A. Cruz, Alexandre F. R. Stewart, Hsiao-Huei Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
LMO4 has been linked genetically to autism spectrum disorder and intellectual disability. Here, the authors investigate a role of LMO4 in parvalbumin neurons and, specifically, the regulation of dorsal ACC inhibitory circuits.
Externí odkaz:
https://doaj.org/article/fe86987c92da4b6d89472524a3eac3c1
Autor:
Li Zhang, Zhaohong Qin, Fariba Sharmin, Wei Lin, Konrad M. Ricke, Michael A. Zasloff, Alexandre F.R. Stewart, Hsiao-Huei Chen
Publikováno v:
Neurobiology of Disease, Vol 156, Iss , Pp 105402- (2021)
Mutations in the beta-amyloid protein (APP) cause familial Alzheimer's disease. In hAPP-J20 mice expressing mutant APP, pharmacological inhibition or genetic ablation of the tyrosine phosphatase PTP1B prevents CA3 hippocampus neuron loss and cognitiv
Externí odkaz:
https://doaj.org/article/0b629ecbb20143d9a03613b3b953c722
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 1, Pp 129-136 (2021)
Ischemic brain injury causes neuronal death and inflammation. Inflammation activates protein-tyrosine phosphatase 1B (PTP1B). Here, we tested the significance of PTP1B activation in glutamatergic projection neurons on functional recovery in two model
Externí odkaz:
https://doaj.org/article/421dbc17737f4991aa3a3e0671616b05
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2515
Neuron death is a key feature of neurological disorders like Alzheimer's or Parkinson's disease (PD). As a result, analysis of neurodegeneration is often considered a central experiment in the postmortem characterization of preclinical PD animal mode
Autor:
Marlene Aßfalg, Markus Rothermel, Thomas Paß, Konrad M. Ricke, Rudolf J. Wiesner, Sandra Blaess, Marianna Tolve
Publikováno v:
Molecular neurobiology 57(9), 3646-3657 (2020). doi:10.1007/s12035-020-01947-w
Molecular Neurobiology
Molecular Neurobiology
Molecular neurobiology 57(9), 3646-3657 (2020). doi:10.1007/s12035-020-01947-w
Published by Humana Press, Totowa, NJ
Published by Humana Press, Totowa, NJ
Autor:
Li Zhang, Konrad M. Ricke, Michael Zasloff, Shelly A. Cruz, Zhaohong Qin, Fariba Sharmin, Hsiao-Huei Chen, Alexandre F.R. Stewart, Kaveh Farrokhi
Publikováno v:
J Neurosci
Alzheimer's disease (AD) is the most common neurodegenerative disorder, resulting in the progressive decline of cognitive function in patients. Familial forms of AD are tied to mutations in the amyloid precursor protein, but the cellular mechanisms t
Publikováno v:
Methods in Molecular Biology ISBN: 9781071624081
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121567224be06801ba47786123e419fc
https://doi.org/10.1007/978-1-0716-2409-8_10
https://doi.org/10.1007/978-1-0716-2409-8_10
Autor:
Kyra Horsthuis, Konrad M. Ricke, Haley M. Geertsma, Zoe Fisk, Terry R. Suk, Maxime W.C. Rousseaux, Jean-Louis A. Parmasad, Steve M. Callaghan
BackgroundA growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to address as controlling the localization of αSyn in experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c7abd24cf1ec676d82ee6b8a8fd599f
https://doi.org/10.1101/2021.10.13.464123
https://doi.org/10.1101/2021.10.13.464123
Autor:
Wei Lin, Michael Zasloff, Fariba Sharmin, Konrad M. Ricke, Hsiao-Huei Chen, Li Zhang, Zhaohong Qin, Alexandre F.R. Stewart
Publikováno v:
Neurobiology of Disease, Vol 156, Iss, Pp 105402-(2021)
Mutations in the beta-amyloid protein (APP) cause familial Alzheimer's disease. In hAPP-J20 mice expressing mutant APP, pharmacological inhibition or genetic ablation of the tyrosine phosphatase PTP1B prevents CA3 hippocampus neuron loss and cognitiv