Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Konrad Knöpper"'
Autor:
Hao Wu, Xiufeng Zhao, Sophia M. Hochrein, Miriam Eckstein, Gabriela F. Gubert, Konrad Knöpper, Ana Maria Mansilla, Arman Öner, Remi Doucet-Ladevèze, Werner Schmitz, Bart Ghesquière, Sebastian Theurich, Jan Dudek, Georg Gasteiger, Alma Zernecke, Sebastian Kobold, Wolfgang Kastenmüller, Martin Vaeth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a precu
Externí odkaz:
https://doaj.org/article/8569ec630ff141898b05f8e21eb43d82
Autor:
Tassnim Abdelwahab, David Stadler, Konrad Knöpper, Panagiota Arampatzi, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller, Rudolf Martini, Janos Groh
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106698- (2023)
Summary: Myelin defects lead to neurological dysfunction in various diseases and in normal aging. Chronic neuroinflammation often contributes to axon-myelin damage in these conditions and can be initiated and/or sustained by perturbed myelinating gli
Externí odkaz:
https://doaj.org/article/47495b32272d46e79ea05d00e9aeda7d
Autor:
Sabrina Giampaolo, Cristina M. Chiarolla, Konrad Knöpper, Martin Vaeth, Matthias Klein, Azeem Muhammad, Tobias Bopp, Friederike Berberich-Siebelt, Amiya K. Patra, Edgar Serfling, Stefan Klein-Hessling
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106234- (2023)
Summary: In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during the double-negative (DN) stages of thymocyte development leads to a marked increase in γδ thymocytes whereas the develo
Externí odkaz:
https://doaj.org/article/674aa6d2228e4a759cbeb67b1400a61e
Autor:
Tassnim Abdelwahab, David Stadler, Konrad Knöpper, Panagiota Arampatzi, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller, Rudolf Martini, Janos Groh
SummaryMyelin defects lead to neurological dysfunction in various diseases and in normal aging. Chronic neuroinflammation often contributes to axon-myelin damage in these conditions and can be initiated and/or sustained by perturbed myelinating glia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc4136982b521cff31db324470b1d60
https://doi.org/10.1101/2023.01.10.523231
https://doi.org/10.1101/2023.01.10.523231
Autor:
Rudolf Martini, Janos Groh, Panagiota Arampatzi, Konrad Knöpper, Lena Lößlein, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller, Xidi Yuan
Publikováno v:
Nature Aging. 1:357-367
Aging is a major risk factor for the development of nervous system functional decline, even in the absence of diseases or trauma. The axon–myelin units and synaptic terminals are some of the neural structures most vulnerable to aging-related deteri
Autor:
Martin Vaeth, Marco A. Ataide, Justus Weber, Hao Wu, Georg Gasteiger, Axel Kallies, Wolfgang Kastenmüller, Sarah Eickhoff, Anika Grafen, Natalio Garbi, Michael Hölzel, Tea Gogishvili, Hermann Einsele, Konrad Knöpper, Michael Hudecek, Karl Komander, Annika E. Peters
Publikováno v:
Nature Immunology
Antiviral CD8+ T cell responses are characterized by an initial activation/priming of T lymphocytes followed by a massive proliferation, subset differentiation, population contraction and the development of a stable memory pool. The transcription fac
The capacity to develop immunological memory is a hallmark of the adaptive immune system. To investigate the role of Samd3 for cellular immune responses and memory development, we generated a conditional knock-out mouse including a fluorescent report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d28ed4fd2f12542364e384c17ffbd70
https://doi.org/10.1002/eji.202149469
https://doi.org/10.1002/eji.202149469
Autor:
Marco A. Ataide, Konrad Knöpper, Paulina Cruz de Casas, Milas Ugur, Sarah Eickhoff, Mangge Zou, Haroon Shaikh, Apurwa Trivedi, Anika Grafen, Tao Yang, Immo Prinz, Knut Ohlsen, Mercedes Gomez de Agüero, Andreas Beilhack, Jochen Huehn, Mauro Gaya, Antoine-Emmanuel Saliba, Georg Gasteiger, Wolfgang Kastenmüller
Publikováno v:
Immunity
Immunity, 2022, 55 (10), pp.1813-1828.e9. ⟨10.1016/j.immuni.2022.07.019⟩
Immunity, 2022, 55 (10), pp.1813-1828.e9. ⟨10.1016/j.immuni.2022.07.019⟩
Lymphatic transport of molecules and migration of myeloid cells to lymph nodes (LNs) continuously inform lymphocytes on changes in drained tissues. Here, using LN transplantation, single-cell RNA-seq, spectral flow cytometry, and a transgenic mouse m
Autor:
Teresa K. Tarrant, Sarah Eickhoff, Konrad Knöpper, Eduardo Reátegui, Maximilian W. Epple, Katharina M. Glaser, Ralf Baumeister, Matthias Gunzer, Wolfgang Kastenmüller, Ronald N. Germain, Daniel Irimia, Michael Mihlan, Tim Lämmermann, Korbinian Kienle
Publikováno v:
Science
Stopping the swarmNeutrophils play a major role in the early immune response and are recruited in large numbers into inflamed and infected tissues. By secreting chemoattractants that bind G protein–coupled receptors (GPCRs) on neighboring cells, ne