Výsledky vyhledávání - "Konrad Keller"

SGK1 Kinase Upregulates GLUT1 Activity and Plasma Membrane Expression

Autor: Jeyaganesh Rajamanickam, Ahmad Akel, Florian Lang, Monica Palmada, Sankarganesh Jeyaraj, Christoph Boehmer, Konrad Keller

Publikováno v: Diabetes. 55:421-427

Phosphatidylinositol 3-kinase (PI3 kinase) inhibition disrupts the ability of insulin to stimulate GLUT1 and GLUT4 translocation into the cell membrane and thus glucose transport. The effect on GLUT4 but not on GLUT1 is mediated by activation of prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3efd4772553e7629477e3a16c9fbaa
https://doi.org/10.2337/diabetes.55.02.06.db05-0720

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Cysteine-Scanning Mutagenesis of Transmembrane Segment 1 of Glucose Transporter GLUT1: Extracellular Accessibility of Helix Positions

Autor: Matthias Heinze, Konrad Keller, Ingrid Monden

Publikováno v: Biochemistry. 43:931-936

Transmembrane segment 1 of the cysteine-less GLUT 1 glucose transporter was subjected to cysteine-scanning mutagenesis. The majority of single-cysteine mutants were functional transporters, as assessed by 2-deoxy-D-glucose uptake or 3-O-methyl-D-gluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e12e3d76e785c42c07780e6b5566285
https://doi.org/10.1021/bi030175w

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Functional consequences of an in vivo mutation in exon 10 of the human GLUT1 gene

Autor: Elena Gertsen, Peter E. Lange, Konrad Keller, Ingrid Monden, Jörg Klepper

Publikováno v: FEBS Letters. 555:274-278

The functional consequences of an in vivo heterozygous insertion mutation in the human facilitated glucose transporter isoform 1 (GLUT1) gene were investigated. The resulting frameshift in exon 10 changed the primary structure of the C-terminus from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbaa49c1ec13fbf6026803eca3bf397
https://doi.org/10.1016/s0014-5793(03)01247-x

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Interaction between paramagnetic metal complexes and intracellular water of single cells

Autor: Konrad Keller, Adolf Zschunke, Sabine Päuser

Publikováno v: Journal of Magnetic Resonance Imaging. 6:250-254

Oocytes from Xenopus laevis were used as a well-established model to investigate spatially resolved changes in relaxation time (T1) within a cell during exposure to copper complexes by means of 'H-NMR-microscopy. T1 relaxation of intracellular water

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6dac33749377947eaa64c3a0ae0ba2
https://doi.org/10.1002/jmri.1880060144

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Functional Consequences of Proline Mutations in the Putative Transmembrane Segments 6 and 10 of the Glucose Transporter GLUT1

Autor: Ingrid Monden, Mike Mueckler, Maren Wellner, Konrad Keller

Publikováno v: European Journal of Biochemistry. 227:454-458

Proline residues are thought to play a characteristic structural and/or dynamic role in various membrane proteins [Williams, K. A. & Deber, C. M. (1991) Biochemistry 30, 8919–8923]. By use of site-directed mutagenesis and functional expression of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8490fcdcf04f6853b816e5a3c2067bd7
https://doi.org/10.1111/j.1432-1033.1995.tb20409.x

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