Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Konrad J. Werhahn"'
Autor:
Michael Rademacher, Manuel Toledo, Wim Van Paesschen, Kore K. Liow, Ivan G. Milanov, Maria‐Luise Esch, Nan Wang, Merran MacPherson, William J. Byrnes, Timothy D. C. Minh, Elizabeth Webster, Konrad J. Werhahn
Publikováno v:
Epilepsia Open, Vol 7, Iss 4, Pp 758-770 (2022)
Abstract Objective To characterize efficacy, safety/tolerability, and pharmacokinetics of padsevonil (PSL) administered concomitantly with ≤3 antiseizure medications (ASMs) for observable focal seizures in adults with drug‐resistant epilepsy in t
Externí odkaz:
https://doaj.org/article/f7b64484d7ee4361b1b24f205981fd0f
Autor:
Michael, Rademacher, Manuel, Toledo, Wim, Van Paesschen, Kore K, Liow, Ivan G, Milanov, Maria-Luise, Esch, Nan, Wang, Merran, MacPherson, William J, Byrnes, Timothy D C, Minh, Elizabeth, Webster, Konrad J, Werhahn
Publikováno v:
Scientia
Antiepileptic drug; Antiseizure medication; Tolerability Fármaco antiepiléptico; Medicamento anticonvulsivo; Tolerabilidad Medicament antiepilèptic; Medicament anticonvulsiu; Tolerabilitat Objective To characterize efficacy, safety/tolerability, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb9dc6cb4102652b5522c8f70f0a494
https://hdl.handle.net/11351/8798
https://hdl.handle.net/11351/8798
Autor:
Viviane E Bernedo Paredes, Hans-Georg Buchholz, Martin Gartenschläger, Markus Breimhorst, Mathias Schreckenberger, Konrad J Werhahn
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141098 (2015)
Dopamine is an endogenous neuromodulator in cortical circuits and the basal ganglia. In animal models of temporal lobe epilepsy (TLE), seizure threshold is modulated to some extent by dopamine, with D1-receptors having a pro- and D2-receptors an anti
Externí odkaz:
https://doaj.org/article/93b96e37306648f2b209652aed177ff0
Autor:
Jonas Hannestad, Bernhard J. Steinhoff, Massimiliano Germani, Koen Van Laere, Konrad J. Werhahn, Christian Otoul, David Sciberras, Manuel Toledo, Christian Brandt, Rafal M. Kaminski, Marian Majoie, Steven DeBruyn, Pierandrea Muglia, Wim Van Paesschen, Brigitte Lacroix, Elizabeth Webster
Publikováno v:
Brain Communications
Brain Communications, 2(2):183. Oxford University Press
Brain Communications, 2(2):183. Oxford University Press
Therapeutic options for patients with treatment-resistant epilepsy represent an important unmet need. Addressing this unmet need was the main factor driving the drug discovery program that led to the synthesis of padsevonil, a first-in-class antiepil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f729a1db940c38ae2356fe351d63866
https://doi.org/10.1093/braincomms/fcaa183
https://doi.org/10.1093/braincomms/fcaa183
Publikováno v:
Epilepsia. 59:1899-1907
Objective To examine serologic markers of vascular risk under treatment with commonly used antiepileptic drugs (AEDs) in the elderly in a randomized setting, and to determine whether the reduced exposure to hydroxymethylglutaryl-CoA reductase inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0cca497ecc3e6a0ff2ac4ea09abc94
https://doi.org/10.1111/epi.14554
https://doi.org/10.1111/epi.14554
Autor:
Konrad J. Werhahn, Jacquelyn L. Bainbridge, Edward Faught, Marc De Backer, Klaus Eckhardt, Aziz Shaibani, David Sen, Frank Tennigkeit, S. Bongardt
Publikováno v:
Epilepsia Open
SummaryObjective To assess the safety profile of lacosamide monotherapy in elderly (≥65 years) subjects with diabetic neuropathic pain (DNP). Methods Of 1,863 DNP subjects in double-blind, randomized, placebo-controlled trials of lacosamide monothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17db5e2a1a9a0cd95f2c912855ad229
http://europepmc.org/articles/PMC5862116
http://europepmc.org/articles/PMC5862116
Autor:
Eugen Trinka, Günter Krämer, Konrad J. Werhahn, Christian Ruckes, Juri-Alexander Witt, Christoph Helmstaedter
Publikováno v:
Acta Neurologica Scandinavica. 130:172-177
Objectives Cognitive comorbidity at epilepsy onset reflects disease severity and provides a baseline estimate of reserve capacities with regard to the effects of epilepsy and its treatment. Given the high incidence of epilepsy at an older age, this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d08b0371b549cc81b9b6b50152cecf
https://doi.org/10.1111/ane.12260
https://doi.org/10.1111/ane.12260
Autor:
Anthony G Marson, Francisco Ramirez, Imane Wild, Konrad J. Werhahn, Matthias Noack-Rink, Eugen Trinka, Bernd Pohlmann-Eden, Azita Tofighy
Publikováno v:
BMC Neurology
BMC NEUROLOGY
BMC NEUROLOGY
Background Few clinical trials have evaluated the efficacy and tolerability of antiepileptic drugs (AEDs) as initial monotherapy for elderly patients. Methods This post-hoc subgroup analysis of data from an unblinded, randomized, 52-week superiority
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a47cb515ab38bcb1abc7479f00f383
https://doi.org/10.1186/s12883-016-0663-7
https://doi.org/10.1186/s12883-016-0663-7
Autor:
Manuel Toledo, Kiyohito Terada, Ting Li, Melissa Brock, Felix Rosenow, Konrad J. Werhahn, Marc De Backer, Michel Baulac
Publikováno v:
The Lancet. Neurology. 16(1)
Summary Background Further options for monotherapy are needed to treat newly diagnosed epilepsy in adults. We assessed the efficacy, safety, and tolerability of lacosamide as a first-line monotherapy option for these patients. Methods In this phase 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8759bc8792bf2ecd0435edc44794f0f9
https://pubmed.ncbi.nlm.nih.gov/28102143
https://pubmed.ncbi.nlm.nih.gov/28102143
Autor:
Viviane Bernedo, Sergey N. Kolbaev, Konrad J. Werhahn, Werner Kilb, Jochen Moser, Salim Sharopov, Heiko J. Luhmann, Rongqing Chen
Publikováno v:
Journal of Neuroscience Research. 90:2020-2033
To investigate whether epileptiform activity in the immature brain is modulated by dopamine, we examined the effects of dopaminergic agonists and antagonists in an intact in vitro preparation of the isolated corticohippocampal formation of immature (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4afb18d1965600a17d8865f0698681b
https://doi.org/10.1002/jnr.23084
https://doi.org/10.1002/jnr.23084