Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Konrad Grützmann"'
Autor:
Konrad Grützmann, Theresa Kraft, Matthias Meinhardt, Friedegund Meier, Dana Westphal, Michael Seifert
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1036-1050 (2024)
Melanoma, the deadliest form of skin cancer, can metastasize to different organs. Molecular differences between brain and extracranial melanoma metastases are poorly understood. Here, promoter methylation and gene expression of 11 heterogeneous patie
Externí odkaz:
https://doaj.org/article/22878d96341a4e81866b8b51ae880f20
Autor:
Konrad Grützmann, Karsten Salomo, Alexander Krüger, Andrea Lohse-Fischer, Kati Erdmann, Michael Seifert, Gustavo Baretton, Daniela Aust, Doreen William, Evelin Schröck, Christian Thomas, Susanne Füssel
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC with high rates of metastasis. Targeted therapies such as tyrosine kinase and checkpoint inhibitors have improved treatment success, but therapy-related sid
Externí odkaz:
https://doaj.org/article/01f8ed8b79a74027a6c7059899fbf7ed
Autor:
Theresa Kraft, Konrad Grützmann, Matthias Meinhardt, Friedegund Meier, Dana Westphal, Michael Seifert
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-22 (2024)
Abstract Melanoma is the most serious type of skin cancer that frequently spreads to other organs of the human body. Especially melanoma metastases to the brain (intracranial metastases) are hard to treat and a major cause of death of melanoma patien
Externí odkaz:
https://doaj.org/article/55c73368a2b9471cab61f1b459487906
Autor:
Zhiyi Xue, Yan Zhang, Ruiqi Zhao, Xiaofei Liu, Konrad Grützmann, Barbara Klink, Xun Zhang, Shuai Wang, Wenbo Zhao, Yanfei Sun, Mingzhi Han, Xu Wang, Yaotian Hu, Xuemeng Liu, Ning Yang, Chen Qiu, Wenjie Li, Bin Huang, Xingang Li, Rolf Bjerkvig, Jian Wang, Wenjing Zhou
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Extensive local invasion of glioblastoma (GBM) cells within the central nervous system (CNS) is one factor that severely limits current treatments. The aim of this study was to uncover genes involved in the invasion process, which
Externí odkaz:
https://doaj.org/article/3709a13eb6e6463d87738a92665b2ac2
Autor:
Celina Tretter, Niklas de Andrade Krätzig, Matteo Pecoraro, Sebastian Lange, Philipp Seifert, Clara von Frankenberg, Johannes Untch, Gabriela Zuleger, Mathias Wilhelm, Daniel P. Zolg, Florian S. Dreyer, Eva Bräunlein, Thomas Engleitner, Sebastian Uhrig, Melanie Boxberg, Katja Steiger, Julia Slotta-Huspenina, Sebastian Ochsenreither, Nikolas von Bubnoff, Sebastian Bauer, Melanie Boerries, Philipp J. Jost, Kristina Schenck, Iska Dresing, Florian Bassermann, Helmut Friess, Daniel Reim, Konrad Grützmann, Katrin Pfütze, Barbara Klink, Evelin Schröck, Bernhard Haller, Bernhard Kuster, Matthias Mann, Wilko Weichert, Stefan Fröhling, Roland Rad, Michael Hiltensperger, Angela M. Krackhardt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Systemic pan-tumor analyses may reveal the significance of common features implicated in cancer immunogenicity and patient survival. Here, we provide a comprehensive multi-omics data set for 32 patients across 25 tumor types for proteogenomi
Externí odkaz:
https://doaj.org/article/1b677a5e3e974d68b06b73bc60798d1c
Autor:
Celina Tretter, Niklas de Andrade Krätzig, Matteo Pecoraro, Sebastian Lange, Philipp Seifert, Clara von Frankenberg, Johannes Untch, Gabriela Zuleger, Mathias Wilhelm, Daniel P. Zolg, Florian S. Dreyer, Eva Bräunlein, Thomas Engleitner, Sebastian Uhrig, Melanie Boxberg, Katja Steiger, Julia Slotta-Huspenina, Sebastian Ochsenreither, Nikolas von Bubnoff, Sebastian Bauer, Melanie Boerries, Philipp J. Jost, Kristina Schenck, Iska Dresing, Florian Bassermann, Helmut Friess, Daniel Reim, Konrad Grützmann, Katrin Pfütze, Barbara Klink, Evelin Schröck, Bernhard Haller, Bernhard Kuster, Matthias Mann, Wilko Weichert, Stefan Fröhling, Roland Rad, Michael Hiltensperger, Angela M. Krackhardt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/6cae0f5158ae4314ac4ec8b239aa4306
Autor:
Yi Han, Pascal Drobisch, Alexander Krüger, Doreen William, Konrad Grützmann, Lukas Böthig, Heike Polster, Lena Seifert, Adrian M. Seifert, Marius Distler, Mathieu Pecqueux, Carina Riediger, Verena Plodeck, Heiner Nebelung, Georg F. Weber, Christian Pilarsky, Ulf Kahlert, Ulf Hinz, Susanne Roth, Thilo Hackert, Jürgen Weitz, Fang Cheng Wong, Christoph Kahlert
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-19 (2023)
Abstract Background The prognosis of pancreatic ductal adenocarcinoma (PDAC) is one of the most dismal of all cancers and the median survival of PDAC patients is only 6–8 months after diagnosis. While decades of research effort have been focused on
Externí odkaz:
https://doaj.org/article/79bb2f022f07438e98c676caf4fc5769
Autor:
Theresa Kraft, Konrad Grützmann, Matthias Meinhardt, Friedegund Meier, Dana Westphal, Michael Seifert
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Melanomas frequently metastasize to distant organs and especially intracranial metastases still represent a major clinical challenge. Epigenetic reprogramming of intracranial metastases is thought to be involved in therapy failure, but so fa
Externí odkaz:
https://doaj.org/article/5672db7cbe3644d286a100524e134228
Autor:
Joris Guyon, Ignacio Fernandez‐Moncada, Claire M Larrieu, Cyrielle L Bouchez, Antonio C Pagano Zottola, Johanna Galvis, Tiffanie Chouleur, Audrey Burban, Kevin Joseph, Vidhya M Ravi, Heidi Espedal, Gro Vatne Røsland, Boutaina Daher, Aurélien Barre, Benjamin Dartigues, Slim Karkar, Justine Rudewicz, Irati Romero‐Garmendia, Barbara Klink, Konrad Grützmann, Marie‐Alix Derieppe, Thibaut Molinié, Nina Obad, Céline Léon, Giorgio Seano, Hrvoje Miletic, Dieter Henrik Heiland, Giovanni Marsicano, Macha Nikolski, Rolf Bjerkvig, Andreas Bikfalvi, Thomas Daubon
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-20 (2022)
Abstract Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, in addition to its
Externí odkaz:
https://doaj.org/article/ba568585186d48d99efb5ec52859e399
Autor:
Falk Zakrzewski, Laura Gieldon, Andreas Rump, Michael Seifert, Konrad Grützmann, Alexander Krüger, Sina Loos, Silke Zeugner, Karl Hackmann, Joseph Porrmann, Johannes Wagner, Karin Kast, Pauline Wimberger, Gustavo Baretton, Evelin Schröck, Daniela Aust, Barbara Klink
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background With the introduction of Olaparib treatment for BRCA-deficient recurrent ovarian cancer, testing for somatic and/or germline mutations in BRCA1/2 genes in tumor tissues became essential for treatment decisions. In most cases only
Externí odkaz:
https://doaj.org/article/5ba4919a6cad4c16b918feb19fd5403a