a genomic-based classification of lung tumors

Autor: Clinical Lung Cancer Genome Project, Network Genomic Medicine, Biospecimens, data source sites: Alex Soltermann, Holger Moch, Odd Terje Brustugun, Steinar Solberg, Marius Lund Iversen, Åslaug Helland, Thomas Muley, Hans Hoffmann, Philipp A. Schnabel, Yuan Chen, Harry Groen, Wim Timens, Hannie Sietsma, Joachim H. Clement, Walter Weder, Jörg Sänger, Erich Stoelben, Corinna Ludwig, Walburga Engel Riedel, Egbert Smit, Daniëlle A. M. Heideman, Peter J. F. Snijders, Lucia Nogova, Martin L. Sos, Christian Mattonet, Karin Töpelt, Matthias Scheffler, Eray Goekkurt, Rainer Kappes, Stefan Krüger, Kato Kambartel, Dirk Behringer, Wolfgang Schulte, Wolfgang Galetke, Winfried Randerath, Matthias Heldwein, Andreas Schlesinger, Monika Serke, Khosro Hekmat, Konrad F. Frank, Roland Schnell, Marcel Reiser, Ali Nuri Hünerlitürkoglu, Stephan Schmitz, Lisa Meffert, Yon Dschun Ko, Markus Litt Lampe, Ulrich Gerigk, Rainer Fricke, Benjamin Besse, Christian Brambilla, Sylvie Lantuejoul, Philippe Lorimier, Denis Moro Sibilot, Federico Cappuzzo, Claudia Ligorio, John K. Field, Russell Hyde, Pierre Validire, Philippe Girard, Lucia A. Muscarella, Vito M. Fazio, Michael Hallek, Jean Charles Soria, Scott L. Carter, Gad Getz, D. Neil Hayes, Matthew D. Wilkerson, Viktor Achter, Ulrich Lang, DAMIANI, STEFANIA

We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically relevant subtypes. More than 55% of all cases had at least one oncogenic genome alteration poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4094::410e1c81df998d7d7d2c499895fea568
http://hdl.handle.net/11585/396000

[Reverse remodeling of the intracellular Ca(2+)-homeostasis: new concepts of pathophysiology and therapy of heart failure]

Autor: Klara, Brixius, Konrad F, Frank, Birgit, Bölck, Felix, Hoyer, Robert H G, Schwinger

Publikováno v: Wiener medizinische Wochenschrift (1946). 156(7-8)

Cardiac contraction is dependent on a rapid alteration of the intracellular Ca(2+) concentration, especially the Ca(2+) released during systole. In end-stage heart failure, cardiac contractility is depressed due to alterations in the structure and fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::907568721ef5e101d6baf8464ead20a3
https://pubmed.ncbi.nlm.nih.gov/16823538