Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Konrad C Bradley"'
Autor:
Hui Li, Konrad C Bradley, Jason S Long, Rebecca Frise, Jonathan W Ashcroft, Lorian C Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao, Wendy S Barclay
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006821 (2018)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1
Externí odkaz:
https://doaj.org/article/d13ec98e444848c6b051d6cd5aaf5ef8
Autor:
Yan Zhang, Jiping Zhu, Yongtao Li, Konrad C Bradley, Jiyue Cao, Huanchun Chen, Meilin Jin, Hongbo Zhou
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61397 (2013)
The two glycosylation sites (Asn142 and Asn177) were observed in the HA of most human seasonal influenza A/H1N1 viruses, while none in pandemic H1N1/2009 influenza A (pH1N1) viruses. We investigated the effect of the two glycosylation sites on viral
Externí odkaz:
https://doaj.org/article/f584947edb854e0d8bd8e6cc4e8c5c13
Autor:
Elizabeth A Driskell, Jennifer A Pickens, Jennifer Humberd-Smith, James T Gordy, Konrad C Bradley, David A Steinhauer, Roy D Berghaus, David E Stallknecht, Elizabeth W Howerth, Stephen Mark Tompkins
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38067 (2012)
Direct transmission of avian influenza viruses to mammals has become an increasingly investigated topic during the past decade; however, isolates that have been primarily investigated are typically ones originating from human or poultry outbreaks. Cu
Externí odkaz:
https://doaj.org/article/6743efa2f2044a30a08d56437f932d45
Autor:
Christine M Oshansky, Jennifer A Pickens, Konrad C Bradley, Les P Jones, Geraldine M Saavedra-Ebner, James P Barber, Jackelyn M Crabtree, David A Steinhauer, S Mark Tompkins, Ralph A Tripp
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21183 (2011)
Avian influenza viruses (AIV) are an important emerging threat to public health. It is thought that sialic acid (sia) receptors are barriers in cross-species transmission where the binding preferences of AIV and human influenza viruses are sias α2,3
Externí odkaz:
https://doaj.org/article/b9f6498bd9c04f23864b1423934ee5fc
Autor:
Konrad C. Bradley, Katja Finsterbusch, Serge Y. Fuchs, Miriam Llorian, Peter Staeheli, Stefania Crotta, Sophia Davidson, Andreas Wack, Daniel Schnepf
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 245-256.e4 (2019)
Summary: Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying mechanisms are unclear. Using models of physiological and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92728f1731d8f45a8ce4742b99f996f2
http://www.sciencedirect.com/science/article/pii/S2211124719307442
http://www.sciencedirect.com/science/article/pii/S2211124719307442
Autor:
Lorian C. Hartgroves, Rebecca Frise, Jason S. Long, Wendy S. Barclay, Holly Shelton, Hui Li, Bin Cao, Spyridon Makris, Konrad C. Bradley, Jonathan W. Ashcroft, Cecilia Johansson
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 1, p e1006821 (2018)
PLoS Pathogens, Vol 14, Iss 1, p e1006821 (2018)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38271877a4a8a2b3cf3d2ea591c7f6f0
http://hdl.handle.net/10044/1/55858
http://hdl.handle.net/10044/1/55858
Autor:
Wendy S. Barclay, Angie Lackenby, Marios Koutsakos, Rebecca Frise, Shanhjahan Miah, Jonathan W. Ashcroft, Ruth A. Elderfield, Konrad C. Bradley
Publikováno v:
Journal of General Virology
The influenza B virus encodes a unique protein, NB, a membrane protein whose function in the replication cycle is not, as yet, understood. We engineered a recombinant influenza B virus lacking NB expression, with no concomitant difference in expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5479627c06c636a6cc5f104b2f040dc9
https://pubmed.ncbi.nlm.nih.gov/26703440
https://pubmed.ncbi.nlm.nih.gov/26703440
Autor:
Xi Chen, Jamie Heimburg-Molinaro, Xuezheng Song, Yi Lasanajak, David F. Smith, Hai Yu, Ganesh R. Talekar, Richard D. Cummings, David A. Steinhauer, Konrad C. Bradley, Summer E. Galloway
Publikováno v:
Journal of Virology. 85:12387-12398
To examine the range of selective processes that potentially operate when poorly binding influenza viruses adapt to replicate more efficiently in alternative environments, we passaged a virus containing an attenuating mutation in the hemagglutinin (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5fd3bb9a9cd369c5a1f4ed6ac541e9
https://doi.org/10.1128/jvi.05570-11
https://doi.org/10.1128/jvi.05570-11
Autor:
Konrad C. Bradley, Christopher D'Angelo, Alexander C. Schmidt, Shenelle-Marie Wise, Peter L. Collins, Olivia S. Kim, Caraline Higgins, Mario H. Skiadopoulos, Brian R. Murphy, Reina Mayor, Sheila M. Nolan, Anne Schaap-Nutt, Emerito Amaro-Carambot, Stephanie D. Davis
Publikováno v:
Virology. 406:65-79
The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4272729e7a6071d7970c5b34deb5e7
https://doi.org/10.1016/j.virol.2010.07.011
https://doi.org/10.1016/j.virol.2010.07.011
Autor:
Konrad C. Bradley, Zhu-Nan Li, William A. Langley, Ganesh R. Talekar, Summer E. Galloway, David A. Steinhauer
Publikováno v:
Vaccine. 28:6305-6313
The use of viral vectors as vaccine candidates has shown promise against a number of pathogens. However, preexisting immunity to these vectors is a concern that must be addressed when deciding which viruses are suitable for use. A number of propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15888ce76145964639b25f83b703a916
https://doi.org/10.1016/j.vaccine.2010.06.112
https://doi.org/10.1016/j.vaccine.2010.06.112